PT-141 studies
171 journal papers mention PT-141 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether PT-141 is safe, effective or approved for any use.
- Papers
- 171
- 130 articles, 41 reviews
- Earliest paper
- 2003
- Most papers in 2025 (20)
- Open access
- 36%
- free to read somewhere
- Reviews
- 24%
- of all papers listed
What kind of studies
Of 112 papers in PubMed that mention PT-141 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials13
- Other clinical trials2
- Meta-analyses and systematic reviews5
- Other reviews57
- Case reports2
- Animal studies only7
- Studies in humans82
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention PT-141 in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 10
- Completed
- 9
- Ongoing or planned
- 1
- Phase 1
- 1
- Phase 2
- 4
- Phase 3
- 3
- Single Dose of Vyleesi in Lactating Female Subjects to Measure the Concentration of Bremelanotide in Breast Milk
NCT06867835CompletedPhase 4started 2025-07-11
- A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With Tirzepatide for the Treatment of Obesity
NCT06565611Active, not recruitingPhase 2started 2024-08-05
- A Phase 3, Bridging, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder (With or Without Decreased Arousal)
NCT04943068CompletedPhase 3started 2021-05-10
- A Phase IIb, Multicenter, Open-Label, Prospective Study of Bremelanotide in Diabetic Kidney Disease
NCT05709444CompletedPhase 2started 2022-12-26
- Role of the Melanocortin-4 Receptor in Hypoactive Sexual Desire Disorder
NCT04179734CompletedPhase 4started 2019-10-07
The five most recently updated studies. See all 10 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
2003 to 2026, peak 20 papers in a year. The latest year may still be incomplete.
Where it is published
- The Journal of Sexual Medicine35 papers
- Obstetrics and Gynecology10 papers
- Inpharma Weekly6 papers
- The Journal of Urology6 papers
- International Journal of Impotence Research5 papers
The papers
Most citedName in the title
- Bremelanotide: First Approval
Sohita Dhillon, Susan J. Keam · Drugs · 2019
Review97 citations
- Bremelanotide for Treatment of Female Hypoactive Sexual Desire
Amber N. Edinoff, Nicole M. Sanders, Kyle B. Lewis et al. · Neurology International · 2022
ReviewOpen access · CC BY37 citationsRead the open copy →
- The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women
James G. Pfaus, Amama Sadiq, Carl Spana et al. · CNS Spectrums · 2021
Review29 citations
- Small Effects, Questionable Outcomes: Bremelanotide for Hypoactive Sexual Desire Disorder
Glen I. Spielmans, Elaine M. Ellefson · The Journal of Sex Research · 2023
Review5 citations
LatestName in title or abstract
- Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review
V Vasylieva, Annette West, Edward Karpman · Sexual Medicine Reviews · 2026
Review
- Clinical trial evidence on emerging pharmacological therapies for hypoactive sexual desire disorder in women: a systematic review and analysis of completed studies registered on ClinicalTrials.gov
Ahmed M. Ashour · Frontiers in Medicine · 2026
Systematic reviewOpen access · CC BYRead the open copy →
- Quantification of “Mercy Sex” in Heterosexual Women
Nikita Guptan, James A. Simon · Journal of Sex & Marital Therapy · 2026
Review
- FDA‐Approved Drugs Containing D‐Amino Acids: A Historical and Developmental Perspective
Linh Tran, Tiến Dũng Nguyễn, Abdelrahman Gamil Gad et al. · Drug Development Research · 2026
Review
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- Strategies for Treating Sexual Health Concerns After Breast and Gynecologic Cancer
Olivia Mihulka, Melissa Curran, Raksha M. Narasimhan et al. · Journal of Minimally Invasive Gynecology · 2025
Review
- (349) Therapeutic Peptides in Sexual Medicine: A Narrative Review
E Burchfiel, N Mills, G Saffati et al. · The Journal of Sexual Medicine · 2025
ReviewOpen accessRead the open copy →
- Practical considerations and emerging approaches for the management of vasomotor and sexual symptoms in breast cancer patients on endocrine therapies
Jessica Fuhrman, Jina Yun, Amy Ly Indorf · Expert Review of Clinical Pharmacology · 2025
Review1 citations
- Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases
Mainak Bardhan, Ayush Anand, Amaan Javed et al. · Diseases · 2025
ReviewOpen access · CC BY5 citationsRead the open copy →
- Female Sexual Desire, Arousal, and Orgasmic Dysfunctions: A Systematic Review and Meta-Analysis of Treatment Options
Rafaela Germano Toledo, William D. Winkelman, Daniela Reyes-Gonzalez et al. · Journal of Minimally Invasive Gynecology · 2025
Meta-analysis6 citations
- Intravenous peptides and amino acids for erectile dysfunction: a narrative review of current applications and future directions
Vishal Ila, Edoardo Pozzi, Miyuru Gamage et al. · Expert Opinion on Pharmacotherapy · 2025
Review
- Novel Pharmacologic Treatments of Female Sexual Dysfunction
Andrew How, Christopher Jowdy, Elli Novatcheva et al. · Clinical Obstetrics & Gynecology · 2025
Review3 citations
- Understanding the Interplay Between Premenstrual Dysphoric Disorder (PMDD) and Female Sexual Dysfunction (FSD)
Mahati Gollapudi, Angelica Thomas, Angelina Yogarajah et al. · Cureus · 2024
ReviewOpen access · CC BY5 citationsRead the open copy →
- Pharmacotherapy of Hypoactive Sexual Desire Disorder in Premenopausal Women
Donna Barakeh, Hadil Mdaihly, Lamis R. Karaoui · Annals of Pharmacotherapy · 2024
Review7 citations
Each list shows up to 40 papers.See all 171 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.