PT-141 studies
171 journal papers mention PT-141 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether PT-141 is safe, effective or approved for any use.
- Papers
- 171
- 130 articles, 41 reviews
- Earliest paper
- 2003
- Most papers in 2025 (20)
- Open access
- 36%
- free to read somewhere
- Reviews
- 24%
- of all papers listed
What kind of studies
Of 112 papers in PubMed that mention PT-141 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials13
- Other clinical trials2
- Meta-analyses and systematic reviews5
- Other reviews57
- Case reports2
- Animal studies only7
- Studies in humans82
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention PT-141 in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 10
- Completed
- 9
- Ongoing or planned
- 1
- Phase 1
- 1
- Phase 2
- 4
- Phase 3
- 3
- Single Dose of Vyleesi in Lactating Female Subjects to Measure the Concentration of Bremelanotide in Breast Milk
NCT06867835CompletedPhase 4started 2025-07-11
- A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With Tirzepatide for the Treatment of Obesity
NCT06565611Active, not recruitingPhase 2started 2024-08-05
- A Phase 3, Bridging, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Evaluate the Efficacy and Safety of Subcutaneously Administered Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder (With or Without Decreased Arousal)
NCT04943068CompletedPhase 3started 2021-05-10
- A Phase IIb, Multicenter, Open-Label, Prospective Study of Bremelanotide in Diabetic Kidney Disease
NCT05709444CompletedPhase 2started 2022-12-26
- Role of the Melanocortin-4 Receptor in Hypoactive Sexual Desire Disorder
NCT04179734CompletedPhase 4started 2019-10-07
The five most recently updated studies. See all 10 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
2003 to 2026, peak 20 papers in a year. The latest year may still be incomplete.
Where it is published
- The Journal of Sexual Medicine35 papers
- Obstetrics and Gynecology10 papers
- Inpharma Weekly6 papers
- The Journal of Urology6 papers
- International Journal of Impotence Research5 papers
The papers
Most citedName in the title
- Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder
Sheryl A. Kingsberg, Anita H. Clayton, David Jay Portman et al. · Obstetrics and Gynecology · 2019
Randomized trial · Phase 3Open access · CC BY-NC-ND294 citationsRead the open copy →
- Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder
James A. Simon, Sheryl A. Kingsberg, David Jay Portman et al. · Obstetrics and Gynecology · 2019
Study in humansOpen access · CC BY-NC-ND198 citationsRead the open copy →
- Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial
Anita H. Clayton, Stanley E. Althof, Sheryl A. Kingsberg et al. · Women s Health · 2016
Randomized trialOpen access · CC BY-NC-ND100 citationsRead the open copy →
- Bremelanotide for Treatment of Female Hypoactive Sexual Desire
Amber N. Edinoff, Nicole M. Sanders, Kyle B. Lewis et al. · Neurology International · 2022
ReviewOpen access · CC BY37 citationsRead the open copy →
- Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials
Carl Spana, Robert Jordan, Steven A. Fischkoff · Diabetes Obesity and Metabolism · 2022
Study in humansOpen access · CC BY-NC-ND15 citationsRead the open copy →
- Phase I Randomized Placebo-controlled, Double-blind Study of the Safety and Tolerability of Bremelanotide Coadministered With Ethanol in Healthy Male and Female Participants
Anita H. Clayton, Johna D. Lucas, Leonard R. Derogatis et al. · Clinical Therapeutics · 2017
Randomized trial · Phase 1Open access · CC BY-NC-ND15 citationsRead the open copy →
- Usefulness of ambulatory blood pressure monitoring to assess the melanocortin receptor agonist bremelanotide
William B. White, Martin G. Myers, Robert Jordan et al. · Journal of Hypertension · 2016
Randomized trialOpen access · CC BY-NC-ND11 citationsRead the open copy →
- Female Syrian hamster analyses of bremelanotide, a US FDA approved drug for the treatment of female hypoactive sexual desire disorder
Johnathan M. Borland, Abigail L. Kohut-Jackson, Anna C. Peyla et al. · Neuropharmacology · 2025
Animal studyOpen access5 citationsRead the open copy →
- Effects of Delta-sleep-inducing, Kisspeptin-10 and pt-141 Neuropeptides on Sexual Behaviour in Male Rats
Svetlana N. Subbotina, Юдин Михаил Анатольевич, А. А. Парфёнова et al. · Journal Biomed · 2021
Open access · CC BY2 citationsRead the open copy →
LatestName in title or abstract
- Goldilocks-Inspired Design of Mid-Size Macrocycles for Selective Targeting of Human Melanocortin Receptors
Francesco Merlino, Li Jia, Ida Boccino et al. · Journal of Medicinal Chemistry · 2026
Study in humansOpen access · CC BYRead the open copy →
- Clinical trial evidence on emerging pharmacological therapies for hypoactive sexual desire disorder in women: a systematic review and analysis of completed studies registered on ClinicalTrials.gov
Ahmed M. Ashour · Frontiers in Medicine · 2026
Systematic reviewOpen access · CC BYRead the open copy →
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- TIRZEPATIDE, ELAMIPRETIDE (SS-31), TESAMORELIN AND BREMELANOTIDE: MECHANISTIC FOUNDATIONS, CLINICAL EVIDENCE AND THERAPEUTIC APPLICATIONS IN METABOLIC, MITOCHONDRIAL AND NEUROENDOCRINE CONTEXTS
Luiz Felippe Mendes Caquetti · INTERNATIONAL BLEST SCIENTIFIC · 2026
Open accessRead the open copy →
- (233) Medical Treatment for Male Orgasmic Disorder: A Real-World Experience
Jacob Hartman‐Kenzler, C Rabeno, J Burger et al. · The Journal of Sexual Medicine · 2025
Open accessRead the open copy →
- (349) Therapeutic Peptides in Sexual Medicine: A Narrative Review
E Burchfiel, N Mills, G Saffati et al. · The Journal of Sexual Medicine · 2025
ReviewOpen accessRead the open copy →
- (396) Comparative Analysis of Flibanserin, Bremelanotide, and Testosterone Therapy for Female Sexual Desire: Mechanism, Efficacy, and Clinical Considerations
S Vereecken, J Achua, J Delgado et al. · The Journal of Sexual Medicine · 2025
Open accessRead the open copy →
- 3. RỐI LOẠN CHỨC NĂNG TÌNH DỤC NỮ: THỰC TRẠNG CHẨN ĐOÁN, ĐIỀU TRỊ VÀ GIẢI PHÁP TẠI VIỆT NAM
Nguyen Duc Quang · Tạp chí Y học Cộng đồng · 2025
Open accessRead the open copy →
- Sexual Concerns in Breast Cancer Survivors
Ayda Soltanian · Archives of Reproductive Medicine · 2025
Open access · CC BY-NCRead the open copy →
- Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases
Mainak Bardhan, Ayush Anand, Amaan Javed et al. · Diseases · 2025
ReviewOpen access · CC BY5 citationsRead the open copy →
- Melanocortin receptors in GtoPdb v.2025.3
Vanni Caruso, Jeffrey B. Tatro, Helgi B. Schiöth et al. · IUPHAR/BPS Guide to Pharmacology CITE · 2025
Open access · CC BY-SARead the open copy →
- Non-hormonal strategies for treating genitourinary syndrome of menopause: a concise review
Rossella Molitierno, Davide Vinci, Nicola Iavazzo et al. · Italian Journal of Gynaecology and Obstetrics · 2025
Open accessRead the open copy →
- A biodegradable suction patch for sustainable transbuccal peptide delivery
Hanna Krupke, Nicole Zoratto, Lucie Rabut et al. · Journal of Controlled Release · 2025
Animal studyOpen access · CC BY7 citationsRead the open copy →
- The evaluation and care of midlife women with hypoactive sexual desire disorder
Jan Leslie Shifren · Menopause The Journal of The North American Menopause Society · 2025
Open access · CC BY-NC-NDRead the open copy →
- (122) POSITIVE EFFECTS OF BREMELANOTIDE ON FEMALE SEXUAL AROUSAL AND ORGASM IN PREMENOPAUSAL WOMEN WITH HSDD: FSFI DATA FROM THE RECONNECT TRIALS
Irwin Goldstein, R Rubin, Sheryl A. Kingsberg et al. · The Journal of Sexual Medicine · 2025
Open accessRead the open copy →
- A look at Hypoactive Sexual Desire Disorder in Women
I. Santos, F. Cunha, R. Andrade et al. · European Psychiatry · 2025
Open access · CC BYRead the open copy →
- Female Syrian hamster analyses of bremelanotide, a US FDA approved drug for the treatment of female hypoactive sexual desire disorder
Johnathan M. Borland, Abigail L. Kohut-Jackson, Anna C. Peyla et al. · Neuropharmacology · 2025
Animal studyOpen access5 citationsRead the open copy →
- Understanding the Interplay Between Premenstrual Dysphoric Disorder (PMDD) and Female Sexual Dysfunction (FSD)
Mahati Gollapudi, Angelica Thomas, Angelina Yogarajah et al. · Cureus · 2024
ReviewOpen access · CC BY5 citationsRead the open copy →
- (035) USE OF BREMELANOTIDE IN MEN WITH SEXUAL DYSFUNCTION AT A SEXUAL MEDICINE CLINIC
Sue W. Goldstein, Irwin Goldstein · The Journal of Sexual Medicine · 2024
Open accessRead the open copy →
- (341) First-time Orgasm in a Man with Flibanserin Use: A Case Report
Gal Saffati, Tahir Naeem, Mohit Khera · The Journal of Sexual Medicine · 2024
Open accessRead the open copy →
- (227) Use of the CNS Agent Bremelanotide in Men with Sexual Dysfunction: Results from a Sexual Medicine Clinic
Irwin Goldstein, Sue W. Goldstein · The Journal of Sexual Medicine · 2024
Open accessRead the open copy →
- (235) Use of Bremelanotide (Vyleesi) in Men with Sexual Dysfunctions
Sue W. Goldstein, Irwin Goldstein · The Journal of Sexual Medicine · 2024
Open access1 citationsRead the open copy →
- (319) Evaluating the Racial Distribution of Clinical Trial Participants for Drugs Leading to FDA Approval of Novel Biologics for the Treatment of Hypoactive Sexual Desire Disorder (HSDD)
Asia N. Matthew-Onabanjo, Marc A. Bjurlin, M Rogers · The Journal of Sexual Medicine · 2024
Open accessRead the open copy →
Each list shows up to 40 papers.See all 171 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.