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Longevity & mitochondria

Humanin studies

625 journal papers mention Humanin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.

Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Humanin is safe, effective or approved for any use.

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Papers
625
556 articles, 69 reviews
Earliest paper
1994
Most papers in 2026 (50)
Open access
56%
free to read somewhere
Reviews
11%
of all papers listed

What kind of studies

Of 547 papers in PubMed that mention Humanin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.

  • Randomized controlled trials5
  • Other clinical trials3
  • Meta-analyses and systematic reviews1
  • Other reviews86
  • Case reports0
  • Animal studies only139
  • Studies in humans318

Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).

Papers per year

1997 to 2026, peak 50 papers in a year. The latest year may still be incomplete.

1997: 1 papers1998: 0 papers1999: 1 papers2000: 0 papers2001: 4 papers2002: 7 papers2003: 15 papers2004: 15 papers2005: 11 papers2006: 21 papers2007: 10 papers2008: 13 papers2009: 23 papers2010: 9 papers2011: 13 papers2012: 12 papers2013: 19 papers2014: 17 papers2015: 21 papers2016: 20 papers2017: 37 papers2018: 30 papers2019: 39 papers2020: 38 papers2021: 39 papers2022: 30 papers2023: 49 papers2024: 36 papers2025: 41 papers2026: 50 papers19972026

Where it is published

  1. Biochemical and Biophysical Research Communications13 papers
  2. Scientific Reports12 papers
  3. The FASEB Journal12 papers
  4. Peptides10 papers
  5. Biochimica et Biophysica Acta (BBA) - General Subjects10 papers

The papers

Most citedName in the title

  1. Humanin: a harbinger of mitochondrial-derived peptides?

    Changhan David Lee, Kelvin Yen, Pinchas Cohen · Trends in Endocrinology and Metabolism · 2013

    Study in humansOpen access284 citationsRead the open copy →

  2. The emerging role of the mitochondrial-derived peptide humanin in stress resistance

    Kelvin Yen, Changhan David Lee, Hemal H. Mehta et al. · Journal of Molecular Endocrinology · 2012

    ReviewOpen access208 citationsRead the open copy →

  3. Humanin and Age-Related Diseases: A New Link?

    Zhenwei Gong, Emir Tas, Radhika H. Muzumdar · Frontiers in Endocrinology · 2014

    ReviewOpen access · CC BY102 citationsRead the open copy →

  4. Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases

    Abu Hazafa, Ammara Batool, Saeed Ahmad et al. · Life Sciences · 2020

    Review96 citations

LatestName in title or abstract

  1. Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility

    Zahra Rostami, Mina Galeshi, Abbas Mosapour · Tissue and Cell · 2026

    Review

  2. Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications

    Gino A. Kurian · Journal of Bioenergetics and Biomembranes · 2026

    Review

  3. The MTRNR2L gene family and age-related macular degeneration

    Adam Moosa, Joshua Jianxin Wang, Margaret M. DeAngelis et al. · Frontiers in Immunology · 2026

    ReviewOpen access · CC BYRead the open copy →

  4. Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review

    Novadri Ayubi, Junian Cahyanto Wibawa, Mert Kurnaz et al. · Physiology International · 2026

    Systematic review

  5. Emerging regulators of human physiology and disease; sORF-encoded microproteins

    Ayman M. Mustafa, Rebaz M. Ali, Sami S. Omar et al. · Epigenomics · 2026

    ReviewOpen accessRead the open copy →

  6. Small but mighty: mitochondrial DNA at the centre of retrograde signalling

    Eve Harding, Veronica Bazzani, Carlo Vascotto · Cell Communication and Signaling · 2026

    ReviewOpen access · CC BY-NC-ND1 citationsRead the open copy →

Each list shows up to 40 papers.See all 625 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.