Humanin studies
625 journal papers mention Humanin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Humanin is safe, effective or approved for any use.
- Papers
- 625
- 556 articles, 69 reviews
- Earliest paper
- 1994
- Most papers in 2026 (50)
- Open access
- 56%
- free to read somewhere
- Reviews
- 11%
- of all papers listed
What kind of studies
Of 547 papers in PubMed that mention Humanin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials5
- Other clinical trials3
- Meta-analyses and systematic reviews1
- Other reviews86
- Case reports0
- Animal studies only139
- Studies in humans318
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
1997 to 2026, peak 50 papers in a year. The latest year may still be incomplete.
Where it is published
- Biochemical and Biophysical Research Communications13 papers
- Scientific Reports12 papers
- The FASEB Journal12 papers
- Peptides10 papers
- Biochimica et Biophysica Acta (BBA) - General Subjects10 papers
The papers
Most citedName in the title
- Humanin peptide suppresses apoptosis by interfering with Bax activation
Bin Guo, Dayong Zhai, Edelmira Cabezas et al. · Nature · 2003
Study in humans620 citations
- Humanin: a harbinger of mitochondrial-derived peptides?
Changhan David Lee, Kelvin Yen, Pinchas Cohen · Trends in Endocrinology and Metabolism · 2013
Study in humansOpen access284 citationsRead the open copy →
- Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
Maaria Ikonen, Bingrong Liu, Yuichi Hashimoto et al. · Proceedings of the National Academy of Sciences · 2003
Study in humansOpen access279 citationsRead the open copy →
- Humanin: A Novel Central Regulator of Peripheral Insulin Action
Radhika H. Muzumdar, Derek M. Huffman, Gil Atzmon et al. · PLoS ONE · 2009
Animal studyOpen access · CC BY249 citationsRead the open copy →
- Humanin vivofluorescence microimaging of the alveolar ducts and sacs during bronchoscopy
Luc Thiberville, Mathieu Salaün, Samy Lachkar et al. · European Respiratory Journal · 2009
Study in humansOpen access230 citationsRead the open copy →
- Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein
Yuichi Hashimoto, Yuko Ito, Takako Niikura et al. · Biochemical and Biophysical Research Communications · 2001
Study in humans226 citations
- Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults
Yuichi Hashimoto, Takako Niikura, Yuko Ito et al. · Journal of Neuroscience · 2001
Study in humansOpen access220 citationsRead the open copy →
- Humanin, a Newly Identified Neuroprotective Factor, Uses the G Protein-Coupled Formylpeptide Receptor-Like-1 as a Functional Receptor
Guoguang Ying, Pablo Iribarren, Ye Zhou et al. · The Journal of Immunology · 2004
Study in humans219 citations
- The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Kelvin Yen, Changhan David Lee, Hemal H. Mehta et al. · Journal of Molecular Endocrinology · 2012
ReviewOpen access208 citationsRead the open copy →
- Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130
Yuichi Hashimoto, Megumi Kurita, Sadakazu Aiso et al. · Molecular Biology of the Cell · 2009
Study in humansOpen access198 citationsRead the open copy →
- Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin
Takako Niikura, Hirohisa Tajima, Yoshiko A. Kita · Current Neuropharmacology · 2006
Open access184 citationsRead the open copy →
- Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress
A Bachar, L. Scheffer, Andreas S. Schroeder et al. · Cardiovascular Research · 2010
Study in humansOpen access182 citationsRead the open copy →
- The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
Parameswaran Gangadharan Sreekumar, Keijiro Ishikawa, Chris Spee et al. · Investigative Ophthalmology & Visual Science · 2016
Study in humansOpen access · CC BY-NC-ND179 citationsRead the open copy →
- Humanin Is a Novel Neuroprotective Agent Against Stroke
Xingshun Xu, Chu Chang Chua, Jinping Gao et al. · Stroke · 2006
Animal study169 citations
- Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice
Radhika H. Muzumdar, Derek M. Huffman, John W. Calvert et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2010
Animal studyOpen access164 citationsRead the open copy →
- Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury
Xingshun Xu, Kao‐Wei Chua, Chu Chang Chua et al. · Brain Research · 2010
Animal studyOpen access150 citationsRead the open copy →
- Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway
Xingshun Xu, Chu Chang Chua, Jinping Gao et al. · Brain Research · 2008
Animal studyOpen access149 citationsRead the open copy →
- Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak
Dayong Zhai, Frédéric Luciano, Xiuwen Zhu et al. · Journal of Biological Chemistry · 2005
Study in humansOpen access · CC BY148 citationsRead the open copy →
- Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults
Hirohisa Tajima, Takako Niikura, Yuichi Hashimoto et al. · Neuroscience Letters · 2002
Study in humans141 citations
- The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice
Phuong T. Hoang, Patricia Park, Laura J. Cobb et al. · Metabolism · 2009
Animal studyOpen access140 citationsRead the open copy →
- Evidence for potential functionality of nuclearly-encoded humanin isoforms
Marek Bodzioch, Katarzyna Lapicka-Bodzioch, Barbara Zapała et al. · Genomics · 2009
Study in humansOpen access123 citationsRead the open copy →
- N-Formylated humanin activates both formyl peptide receptor-like 1 and 2
Masataka Harada, Yugo Habata, Masaki Hosoya et al. · Biochemical and Biophysical Research Communications · 2004
Study in humans119 citations
- Circulating humanin levels are associated with preserved coronary endothelial function
Robert Jay Widmer, Andreas J. Flammer, Sandra M. Herrmann et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2012
Study in humansOpen access117 citationsRead the open copy →
- The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus
Su‐Jeong Kim, Noel Guerrero, Gabriella Wassef et al. · Oncotarget · 2016
Study in humansOpen access · CC BY116 citationsRead the open copy →
- Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
Frédéric Luciano, Dayong Zhai, Xiuwen Zhu et al. · Journal of Biological Chemistry · 2005
Study in humansOpen access · CC BY115 citationsRead the open copy →
- A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults
Takako Niikura, Yuichi Hashimoto, Hirohisa Tajima et al. · European Journal of Neuroscience · 2003
Animal study115 citations
- Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice
Yun Kyu Oh, Adi R. Bachar, David G. Zacharias et al. · Atherosclerosis · 2011
Animal studyOpen access114 citationsRead the open copy →
- [Gly14]‐Humanin improved the learning and memory impairment induced by scopolamine in vivo
Takayoshi Mamiya, Makoto Ukai · British Journal of Pharmacology · 2001
Animal studyOpen access113 citationsRead the open copy →
- The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Kelvin Yen, Hemal H. Mehta, Su‐Jeong Kim et al. · Aging · 2020
Study in humansOpen access · CC BY109 citationsRead the open copy →
- Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection
Yuichi Hashimoto, Hiroaki Suzuki, Sadakazu Aiso et al. · Life Sciences · 2005
Study in humans108 citations
- Toward an improved prediction of humanin vivobrain penetration
Scott G. Summerfield, Adam J. Lucas, Rod A. Porter et al. · Xenobiotica · 2008
Study in humans105 citations
- Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults
Yohichi Yamagishi, Yuichi Hashimoto, Takako Niikura et al. · Peptides · 2003
Animal study105 citations
- Humanin and Age-Related Diseases: A New Link?
Zhenwei Gong, Emir Tas, Radhika H. Muzumdar · Frontiers in Endocrinology · 2014
ReviewOpen access · CC BY102 citationsRead the open copy →
- Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1‐Mediated Transcriptional Regulation of the Humanin Polypeptide Family
Aruo Nan, Lijian Chen, Nan Zhang et al. · Advanced Science · 2018
Open access · CC BY101 citationsRead the open copy →
- Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans
Kelvin Yen, Junxiang Wan, Hemal H. Mehta et al. · Scientific Reports · 2018
Study in humansOpen access · CC BY97 citationsRead the open copy →
- Tumor Necrosis Factor-α Modulates Humanin VivoLipolysis
Peter Plomgaard, Christian Philip Fischer, Tobias Ibfelt et al. · The Journal of Clinical Endocrinology & Metabolism · 2007
Randomized trial97 citations
- Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
Abu Hazafa, Ammara Batool, Saeed Ahmad et al. · Life Sciences · 2020
Review96 citations
- A humanin derivative, S14G‐HN, prevents amyloid‐β‐induced memory impairment in mice
Hirohisa Tajima, Masaoki Kawasumi, Tomohiro Chiba et al. · Journal of Neuroscience Research · 2005
Study in humans96 citations
- Humanin is an endogenous activator of chaperone-mediated autophagy
Zhenwei Gong, Inmaculada Tasset, Antonio Díaz et al. · The Journal of Cell Biology · 2017
Animal studyOpen access · CC BY-NC-SA95 citationsRead the open copy →
- A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts
Laura E. Klein, Lingguang Cui, Zhenwei Gong et al. · Biochemical and Biophysical Research Communications · 2013
Animal studyOpen access95 citationsRead the open copy →
LatestName in title or abstract
- Mitochondrial-derived peptides: emerging therapeutic targets at the intersection of mitochondrial dysfunction and pain
Zhe Wang, Jinglei Liao, Ping Lu et al. · Frontiers in Pain Research · 2026
Open access · CC BYRead the open copy →
- Humanin attenuates neuronal cellular senescence and preserves neurotransmitter release in differentiated PC12 cells
棚橋美紀, Ayari Kozuka, Nobuyuki Sasakawa et al. · Neuroscience · 2026
- Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility
Zahra Rostami, Mina Galeshi, Abbas Mosapour · Tissue and Cell · 2026
Review
- Neuroprotective effects of [Gly14]-Humanin against cisplatin-induced neurotoxicity: evidence from in vitro and in vivo studies
Sedat Gökmen, İrfan Çınar, Kıymet Kübra Tüfekci̇ et al. · BMC Pharmacology and Toxicology · 2026
Open access · CC BY-NC-NDRead the open copy →
- Humanin variants differentially regulate BID fibrilization and suppress BAX- and BID-dependent membrane permeabilization
Rashmi Puja, Daniel Luzon Morris, Zong-Heng Wang et al. · Journal of Biological Chemistry · 2026
Open access · CC BY-NC-NDRead the open copy →
- Mitochondrial Peptide SHLP2 Limits Poly(I: C)-Induced Alveolar Epithelial Injury by Modulating Redox, Apoptotic, Inflammatory, and Inflammasome Responses
Sara Betül Ramazan, Bedircan Turan, Ayşegül Türkkol et al. · Cytotechnology · 2026
Open accessRead the open copy →
- Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications
Gino A. Kurian · Journal of Bioenergetics and Biomembranes · 2026
Review
- Humanin Attenuates Inflammatory Liver Injury and NF-κB Activation During Systemic Hypervirulent Klebsiella pneumoniae Infection
Yi-Ming Zhong, Dina Haishaer, Weidong Cai et al. · Pathogens · 2026
Study in humansOpen access · CC BYRead the open copy →
- The MTRNR2L gene family and age-related macular degeneration
Adam Moosa, Joshua Jianxin Wang, Margaret M. DeAngelis et al. · Frontiers in Immunology · 2026
ReviewOpen access · CC BYRead the open copy →
- S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats
Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal et al. · Experimental Physiology · 2026
Animal studyOpen access · CC BYRead the open copy →
- Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review
Novadri Ayubi, Junian Cahyanto Wibawa, Mert Kurnaz et al. · Physiology International · 2026
Systematic review
- Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux
George Anderson · ALPHA PSYCHIATRY · 2026
Open access · CC BYRead the open copy →
- Emerging regulators of human physiology and disease; sORF-encoded microproteins
Ayman M. Mustafa, Rebaz M. Ali, Sami S. Omar et al. · Epigenomics · 2026
ReviewOpen accessRead the open copy →
- Mitochondrial-Derived Peptides, Blood Glucose, and Glycated Hemoglobin Levels in Men with Type 2 Diabetes, Atherosclerosis, or Hypertension: A Cross-Sectional Study
Inass Majid Mozan, Zainab Abdul Jabbar Ridha AL-ALI, Redha Alwan Hasan · PERIÓDICO TCHÊ QUÍMICA · 2026
Open access · CC BYRead the open copy →
- AGEs–RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition
Mohamed E. Suliman, Awahan Rahman, Abdul Rashid Qureshi et al. · Antioxidants · 2026
Open access · CC BYRead the open copy →
- S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis
Yan Liu, Chun Hu, Shilu Luo et al. · European Journal of Pharmacology · 2026
Study in humans3 citations
- 0564 Humanin: The new mitopeptide messenger of skin longevity promoted by an innovative Iris pallida root extract
Y. Ferreira, Audrey Le Mestr, Ludivine Mur et al. · Journal of Investigative Dermatology · 2026
- Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats
Rumeysa Esra Kom, Eda Çoban Ercan, Mehmet Emre Akipek et al. · Reproductive Biology · 2026
Open access · CC BY-NC-NDRead the open copy →
- Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats
Bin Lin, Kevin Schneider, Mustafa Ozgul et al. · Scientific Reports · 2026
Open access · CC BYRead the open copy →
- Humanin ameliorates diabetes‐induced testicular damage in a streptozotocin‐induced mouse model
Munevver Gizem Hekım, Nalan Kaya Tektemur, Mete Özcan · Experimental Physiology · 2026
Animal studyOpen access · CC BYRead the open copy →
- Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class)
Mohd Shahzaib, Domenico Aprile, Gianluigi Laporta et al. · Biomolecules · 2026
Study in humansOpen access · CC BYRead the open copy →
- Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue
Ferah Bulut, Muhammed Adam, Munevver Gizem Hekım et al. · Biology · 2026
Open access · CC BYRead the open copy →
- Evaluation of the role of humanin and some biochemical variables in type 2 diabetes patients
Reham Ahmed, Rana Jasim · Journal of Wahj Al-Ulom for Pure Sciences · 2026
- Altered placental expression of small humanin-like peptides in gestational diabetes mellitus
Sude Dagli, Merve Ece Oyur, Bedircan Turan et al. · Upsala Journal of Medical Sciences · 2026
Study in humansOpen access · CC BYRead the open copy →
- Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions
Julia G Conte, Sofía Reynoso, María Sol Gosso et al. · Reproduction · 2026
Study in humans
- Circulating mitochondrial‐derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy
Oscar Horwath, Linnéa Corell, Junxiang Wan et al. · Experimental Physiology · 2026
Study in humansOpen access · CC BYRead the open copy →
- Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK ‐Beclin1‐Dependent Mitophagy
H D Jang, Suyeon Choi, SC Kim et al. · Aging Cell · 2026
Study in humansOpen access · CC BYRead the open copy →
- Humanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle
Amare Eshetu Gemeda, Dr M K Singh, Rahul Katiyar et al. · Reproduction in Domestic Animals · 2026
Animal study
- Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice
Ferah Bulut, Muhammed Adam, Aslışah Özgen et al. · Metabolites · 2026
Open access · CC BY1 citationsRead the open copy →
- Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction
Yingying Liao, Jie Xu, Yuheng Jiao et al. · Biomedicines · 2026
Open access · CC BYRead the open copy →
- Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway
Yaohui Shan, X Liu, Wei Ge et al. · Toxicology and Industrial Health · 2026
Animal study
- Circadian astrocyte mitochondrial humanin regulates microglia and neuronal mitochondrial melatonergic pathway, with implications for aging and neurodegenerative conditions
George Anderson · Exploration of neuroscience · 2026
Open access · CC BY1 citationsRead the open copy →
- Preserving brain health in aging: structural and biochemical benefits of water based resistance training, a randomized controlled trial
Mahdiyeh Haj Hosseini, Masoumeh Baghalishahi, Mandana Moshrefi et al. · BMC Geriatrics · 2026
Randomized trialOpen access · CC BY-NC-ND1 citationsRead the open copy →
- Humanin-G protects septic acute respiratory distress syndrome by mediating mitochondrial function in lung vascular endothelial cells
Xiaomei Wu, Y H Li, Xuwen Lin et al. · American Journal of Respiratory Cell and Molecular Biology · 2026
Study in humans1 citations
- Small but mighty: mitochondrial DNA at the centre of retrograde signalling
Eve Harding, Veronica Bazzani, Carlo Vascotto · Cell Communication and Signaling · 2026
ReviewOpen access · CC BY-NC-ND1 citationsRead the open copy →
- Arsenic Promotes Intracellular Aβ(1−42) Accumulation via Enhanced APP but Reduced NEP Expression, and Indirectly Stimulates Extracellular Aβ Aggregation through AChE Induction in Differentiated SH-SY5Y Cells
Naphada Leelaprachakul, Daranee Visitnonthachai, Apichaya Niyomchan et al. · Biological Trace Element Research · 2026
Study in humans
- Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity
Mohd Shahzaib, Domenico Aprile, Nicola Alessio et al. · Free Radical Biology and Medicine · 2026
Study in humansOpen access · CC BYRead the open copy →
- Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients
Davide Bolignano, Marta Greco, Sara Pugliese et al. · Cardiorenal Medicine · 2026
Study in humansOpen access · CC BY-NCRead the open copy →
- Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin–Nox2 interaction in cardioprotection
Roberto Vicinanza, Vittoria Cammisotto, Junxiang Wan et al. · Frontiers in Nutrition · 2026
Open access · CC BYRead the open copy →
- Impact of bioactive peptides on neurodegenerative diseases: Biochemical pathways and potential therapies
Henrik Johansson · International Journal of Advanced Biochemistry Research · 2026
Open accessRead the open copy →
Each list shows up to 40 papers.See all 625 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.