Humanin studies
625 journal papers mention Humanin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Humanin is safe, effective or approved for any use.
- Papers
- 625
- 556 articles, 69 reviews
- Earliest paper
- 1994
- Most papers in 2026 (50)
- Open access
- 56%
- free to read somewhere
- Reviews
- 11%
- of all papers listed
What kind of studies
Of 547 papers in PubMed that mention Humanin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials5
- Other clinical trials3
- Meta-analyses and systematic reviews1
- Other reviews86
- Case reports0
- Animal studies only139
- Studies in humans318
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
1997 to 2026, peak 50 papers in a year. The latest year may still be incomplete.
Where it is published
- Biochemical and Biophysical Research Communications13 papers
- Scientific Reports12 papers
- The FASEB Journal12 papers
- Peptides10 papers
- Biochimica et Biophysica Acta (BBA) - General Subjects10 papers
The papers
Most citedName in the title
- Humanin: a harbinger of mitochondrial-derived peptides?
Changhan David Lee, Kelvin Yen, Pinchas Cohen · Trends in Endocrinology and Metabolism · 2013
Study in humansOpen access284 citationsRead the open copy →
- Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
Maaria Ikonen, Bingrong Liu, Yuichi Hashimoto et al. · Proceedings of the National Academy of Sciences · 2003
Study in humansOpen access279 citationsRead the open copy →
- Humanin: A Novel Central Regulator of Peripheral Insulin Action
Radhika H. Muzumdar, Derek M. Huffman, Gil Atzmon et al. · PLoS ONE · 2009
Animal studyOpen access · CC BY249 citationsRead the open copy →
- Humanin vivofluorescence microimaging of the alveolar ducts and sacs during bronchoscopy
Luc Thiberville, Mathieu Salaün, Samy Lachkar et al. · European Respiratory Journal · 2009
Study in humansOpen access230 citationsRead the open copy →
- Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults
Yuichi Hashimoto, Takako Niikura, Yuko Ito et al. · Journal of Neuroscience · 2001
Study in humansOpen access220 citationsRead the open copy →
- The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Kelvin Yen, Changhan David Lee, Hemal H. Mehta et al. · Journal of Molecular Endocrinology · 2012
ReviewOpen access208 citationsRead the open copy →
- Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130
Yuichi Hashimoto, Megumi Kurita, Sadakazu Aiso et al. · Molecular Biology of the Cell · 2009
Study in humansOpen access198 citationsRead the open copy →
- Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin
Takako Niikura, Hirohisa Tajima, Yoshiko A. Kita · Current Neuropharmacology · 2006
Open access184 citationsRead the open copy →
- Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress
A Bachar, L. Scheffer, Andreas S. Schroeder et al. · Cardiovascular Research · 2010
Study in humansOpen access182 citationsRead the open copy →
- The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
Parameswaran Gangadharan Sreekumar, Keijiro Ishikawa, Chris Spee et al. · Investigative Ophthalmology & Visual Science · 2016
Study in humansOpen access · CC BY-NC-ND179 citationsRead the open copy →
- Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice
Radhika H. Muzumdar, Derek M. Huffman, John W. Calvert et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2010
Animal studyOpen access164 citationsRead the open copy →
- Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury
Xingshun Xu, Kao‐Wei Chua, Chu Chang Chua et al. · Brain Research · 2010
Animal studyOpen access150 citationsRead the open copy →
- Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway
Xingshun Xu, Chu Chang Chua, Jinping Gao et al. · Brain Research · 2008
Animal studyOpen access149 citationsRead the open copy →
- Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak
Dayong Zhai, Frédéric Luciano, Xiuwen Zhu et al. · Journal of Biological Chemistry · 2005
Study in humansOpen access · CC BY148 citationsRead the open copy →
- The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice
Phuong T. Hoang, Patricia Park, Laura J. Cobb et al. · Metabolism · 2009
Animal studyOpen access140 citationsRead the open copy →
- Evidence for potential functionality of nuclearly-encoded humanin isoforms
Marek Bodzioch, Katarzyna Lapicka-Bodzioch, Barbara Zapała et al. · Genomics · 2009
Study in humansOpen access123 citationsRead the open copy →
- Circulating humanin levels are associated with preserved coronary endothelial function
Robert Jay Widmer, Andreas J. Flammer, Sandra M. Herrmann et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2012
Study in humansOpen access117 citationsRead the open copy →
- The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus
Su‐Jeong Kim, Noel Guerrero, Gabriella Wassef et al. · Oncotarget · 2016
Study in humansOpen access · CC BY116 citationsRead the open copy →
- Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
Frédéric Luciano, Dayong Zhai, Xiuwen Zhu et al. · Journal of Biological Chemistry · 2005
Study in humansOpen access · CC BY115 citationsRead the open copy →
- Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice
Yun Kyu Oh, Adi R. Bachar, David G. Zacharias et al. · Atherosclerosis · 2011
Animal studyOpen access114 citationsRead the open copy →
- [Gly14]‐Humanin improved the learning and memory impairment induced by scopolamine in vivo
Takayoshi Mamiya, Makoto Ukai · British Journal of Pharmacology · 2001
Animal studyOpen access113 citationsRead the open copy →
- The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Kelvin Yen, Hemal H. Mehta, Su‐Jeong Kim et al. · Aging · 2020
Study in humansOpen access · CC BY109 citationsRead the open copy →
- Humanin and Age-Related Diseases: A New Link?
Zhenwei Gong, Emir Tas, Radhika H. Muzumdar · Frontiers in Endocrinology · 2014
ReviewOpen access · CC BY102 citationsRead the open copy →
- Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1‐Mediated Transcriptional Regulation of the Humanin Polypeptide Family
Aruo Nan, Lijian Chen, Nan Zhang et al. · Advanced Science · 2018
Open access · CC BY101 citationsRead the open copy →
- Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans
Kelvin Yen, Junxiang Wan, Hemal H. Mehta et al. · Scientific Reports · 2018
Study in humansOpen access · CC BY97 citationsRead the open copy →
- Humanin is an endogenous activator of chaperone-mediated autophagy
Zhenwei Gong, Inmaculada Tasset, Antonio Díaz et al. · The Journal of Cell Biology · 2017
Animal studyOpen access · CC BY-NC-SA95 citationsRead the open copy →
- A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts
Laura E. Klein, Lingguang Cui, Zhenwei Gong et al. · Biochemical and Biophysical Research Communications · 2013
Animal studyOpen access95 citationsRead the open copy →
LatestName in title or abstract
- Mitochondrial-derived peptides: emerging therapeutic targets at the intersection of mitochondrial dysfunction and pain
Zhe Wang, Jinglei Liao, Ping Lu et al. · Frontiers in Pain Research · 2026
Open access · CC BYRead the open copy →
- Neuroprotective effects of [Gly14]-Humanin against cisplatin-induced neurotoxicity: evidence from in vitro and in vivo studies
Sedat Gökmen, İrfan Çınar, Kıymet Kübra Tüfekci̇ et al. · BMC Pharmacology and Toxicology · 2026
Open access · CC BY-NC-NDRead the open copy →
- Humanin variants differentially regulate BID fibrilization and suppress BAX- and BID-dependent membrane permeabilization
Rashmi Puja, Daniel Luzon Morris, Zong-Heng Wang et al. · Journal of Biological Chemistry · 2026
Open access · CC BY-NC-NDRead the open copy →
- Mitochondrial Peptide SHLP2 Limits Poly(I: C)-Induced Alveolar Epithelial Injury by Modulating Redox, Apoptotic, Inflammatory, and Inflammasome Responses
Sara Betül Ramazan, Bedircan Turan, Ayşegül Türkkol et al. · Cytotechnology · 2026
Open accessRead the open copy →
- Humanin Attenuates Inflammatory Liver Injury and NF-κB Activation During Systemic Hypervirulent Klebsiella pneumoniae Infection
Yi-Ming Zhong, Dina Haishaer, Weidong Cai et al. · Pathogens · 2026
Study in humansOpen access · CC BYRead the open copy →
- The MTRNR2L gene family and age-related macular degeneration
Adam Moosa, Joshua Jianxin Wang, Margaret M. DeAngelis et al. · Frontiers in Immunology · 2026
ReviewOpen access · CC BYRead the open copy →
- S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats
Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal et al. · Experimental Physiology · 2026
Animal studyOpen access · CC BYRead the open copy →
- Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux
George Anderson · ALPHA PSYCHIATRY · 2026
Open access · CC BYRead the open copy →
- Emerging regulators of human physiology and disease; sORF-encoded microproteins
Ayman M. Mustafa, Rebaz M. Ali, Sami S. Omar et al. · Epigenomics · 2026
ReviewOpen accessRead the open copy →
- Mitochondrial-Derived Peptides, Blood Glucose, and Glycated Hemoglobin Levels in Men with Type 2 Diabetes, Atherosclerosis, or Hypertension: A Cross-Sectional Study
Inass Majid Mozan, Zainab Abdul Jabbar Ridha AL-ALI, Redha Alwan Hasan · PERIÓDICO TCHÊ QUÍMICA · 2026
Open access · CC BYRead the open copy →
- AGEs–RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition
Mohamed E. Suliman, Awahan Rahman, Abdul Rashid Qureshi et al. · Antioxidants · 2026
Open access · CC BYRead the open copy →
- Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats
Rumeysa Esra Kom, Eda Çoban Ercan, Mehmet Emre Akipek et al. · Reproductive Biology · 2026
Open access · CC BY-NC-NDRead the open copy →
- Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats
Bin Lin, Kevin Schneider, Mustafa Ozgul et al. · Scientific Reports · 2026
Open access · CC BYRead the open copy →
- Humanin ameliorates diabetes‐induced testicular damage in a streptozotocin‐induced mouse model
Munevver Gizem Hekım, Nalan Kaya Tektemur, Mete Özcan · Experimental Physiology · 2026
Animal studyOpen access · CC BYRead the open copy →
- Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class)
Mohd Shahzaib, Domenico Aprile, Gianluigi Laporta et al. · Biomolecules · 2026
Study in humansOpen access · CC BYRead the open copy →
- Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue
Ferah Bulut, Muhammed Adam, Munevver Gizem Hekım et al. · Biology · 2026
Open access · CC BYRead the open copy →
- Altered placental expression of small humanin-like peptides in gestational diabetes mellitus
Sude Dagli, Merve Ece Oyur, Bedircan Turan et al. · Upsala Journal of Medical Sciences · 2026
Study in humansOpen access · CC BYRead the open copy →
- Circulating mitochondrial‐derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy
Oscar Horwath, Linnéa Corell, Junxiang Wan et al. · Experimental Physiology · 2026
Study in humansOpen access · CC BYRead the open copy →
- Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK ‐Beclin1‐Dependent Mitophagy
H D Jang, Suyeon Choi, SC Kim et al. · Aging Cell · 2026
Study in humansOpen access · CC BYRead the open copy →
- Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice
Ferah Bulut, Muhammed Adam, Aslışah Özgen et al. · Metabolites · 2026
Open access · CC BY1 citationsRead the open copy →
- Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction
Yingying Liao, Jie Xu, Yuheng Jiao et al. · Biomedicines · 2026
Open access · CC BYRead the open copy →
- Circadian astrocyte mitochondrial humanin regulates microglia and neuronal mitochondrial melatonergic pathway, with implications for aging and neurodegenerative conditions
George Anderson · Exploration of neuroscience · 2026
Open access · CC BY1 citationsRead the open copy →
- Preserving brain health in aging: structural and biochemical benefits of water based resistance training, a randomized controlled trial
Mahdiyeh Haj Hosseini, Masoumeh Baghalishahi, Mandana Moshrefi et al. · BMC Geriatrics · 2026
Randomized trialOpen access · CC BY-NC-ND1 citationsRead the open copy →
- Small but mighty: mitochondrial DNA at the centre of retrograde signalling
Eve Harding, Veronica Bazzani, Carlo Vascotto · Cell Communication and Signaling · 2026
ReviewOpen access · CC BY-NC-ND1 citationsRead the open copy →
- Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity
Mohd Shahzaib, Domenico Aprile, Nicola Alessio et al. · Free Radical Biology and Medicine · 2026
Study in humansOpen access · CC BYRead the open copy →
- Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients
Davide Bolignano, Marta Greco, Sara Pugliese et al. · Cardiorenal Medicine · 2026
Study in humansOpen access · CC BY-NCRead the open copy →
- Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin–Nox2 interaction in cardioprotection
Roberto Vicinanza, Vittoria Cammisotto, Junxiang Wan et al. · Frontiers in Nutrition · 2026
Open access · CC BYRead the open copy →
- Impact of bioactive peptides on neurodegenerative diseases: Biochemical pathways and potential therapies
Henrik Johansson · International Journal of Advanced Biochemistry Research · 2026
Open accessRead the open copy →
Each list shows up to 40 papers.See all 625 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.