Epitalon studies
113 journal papers mention Epitalon in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Epitalon is safe, effective or approved for any use.
- Papers
- 113
- 108 articles, 5 reviews
- Earliest paper
- 1990
- Most papers in 2004 (11)
- Open access
- 24%
- free to read somewhere
- Reviews
- 4%
- of all papers listed
What kind of studies
Of 166 papers in PubMed that mention Epitalon in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials5
- Other clinical trials2
- Meta-analyses and systematic reviews0
- Other reviews19
- Case reports0
- Animal studies only103
- Studies in humans59
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Epitalon in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 1
- Completed
- 0
- Ongoing or planned
- 1
- Phase 1
- 0
- Phase 2
- 0
- Phase 3
- 0
- Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
NCT07888595Enrolling by invitationEarly phase 1started 2026-10-21
The five most recently updated studies. See all 1 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 11 papers in a year. The latest year may still be incomplete.
Where it is published
- Bulletin of Experimental Biology and Medicine42 papers
- Advances in Gerontology7 papers
- Neuroscience and Behavioral Physiology4 papers
- Annals of the New York Academy of Sciences4 papers
- International Journal of Molecular Sciences3 papers
The papers
Most citedName in the title
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Vladimir Kh. Khavinson, Francesca Diomede, Ekaterina Sergeevna Mironova et al. · Molecules · 2020
Study in humansOpen access · CC BY30 citationsRead the open copy →
- Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties
Szymon Kamil Araj, Jakub Brzezik, Katarzyna Mądra-Gackowska et al. · International Journal of Molecular Sciences · 2025
ReviewOpen access · CC BY10 citationsRead the open copy →
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue Xue, Sai‐Li Liu, Jia-Ni Guo et al. · Aging · 2022
Animal studyOpen access · CC BY8 citationsRead the open copy →
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Sarah Al-dulaimi, Ross Thomas, Sheila Matta et al. · Biogerontology · 2025
Study in humansOpen access · CC BY5 citationsRead the open copy →
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Marco Gatta, Melania Dovizio, Cristina Milillo et al. · Stem Cell Reviews and Reports · 2025
Study in humansOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Anti-mutagenic action of synthetic “epitalon” peptide in mice with different body colour
S. V. Mylnikov, Natalia Pavlova, Larisa Vladimirovna Barabanova · Ecological genetics · 2011
Open access · CC BY2 citationsRead the open copy →
LatestName in title or abstract
- Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence
Ankur Jain, David M. Gallacher, Mohammed A. Issa et al. · International Journal of Molecular Sciences · 2026
ReviewOpen access · CC BYRead the open copy →
- The peptide boom: a critical appraisal of evidence, patient safety risks, and regulatory failure in the experimental wellness peptide market
Giorgi Pkhakadze · Georgian Medical Journal · 2026
Open access · CC BYRead the open copy →
- The microgram hypothesis: a translational dosing error in Epitalon peptide research and its implications for human aging application
Chang-Hun Jung · Aging Pathobiology and Therapeutics · 2026
Open access · CC BY-NC-SARead the open copy →
- PEPTIDE BIOREGULATORS, AGING AND HUMAN LONGEVITY: EPITHALON, THYMALIN, THYMOGEN, DSIP, VILON AND VESUGEN IN CIRCADIAN BIOLOGY, TELOMERASE REGULATION AND INFLAMMAGING
Luiz Felippe Mendes Caquetti · INTERNATIONAL BLEST SCIENTIFIC · 2026
Open accessRead the open copy →
- LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma
Yue Zhang, Siyu Qian, Qing Yang et al. · Cell Death and Disease · 2026
Study in humansOpen access · CC BY1 citationsRead the open copy →
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Omar F. Rahman, Steven J. Lee, William A. Seeds · JAAOS Global Research and Reviews · 2026
ReviewOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Sarah Al-dulaimi, Ross Thomas, Sheila Matta et al. · Biogerontology · 2025
Study in humansOpen access · CC BY5 citationsRead the open copy →
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Marco Gatta, Melania Dovizio, Cristina Milillo et al. · Stem Cell Reviews and Reports · 2025
Study in humansOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties
Szymon Kamil Araj, Jakub Brzezik, Katarzyna Mądra-Gackowska et al. · International Journal of Molecular Sciences · 2025
ReviewOpen access · CC BY10 citationsRead the open copy →
- Bioactive Anti-Aging Substances: Geroprotectors
Anna Fokina, Anna Dmitrievna Vesnina, Anna Sergeevna Frolova et al. · Food Processing Techniques and Technology · 2024
Open access · CC BY8 citationsRead the open copy →
- Improving Biological Age, Telomere Length, and Cognition: A Case Report on the Use of Therapeutic Plasma Exchange, Peptides, Umbilical Cord Tissue Mesenchymal Stem Cells and Exosomes in a Patient with Cognitive Decline
Edwin Ho Ming Lee, Morgan Burns · Journal of Restorative Medicine · 2024
Open access1 citationsRead the open copy →
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue Xue, Sai‐Li Liu, Jia-Ni Guo et al. · Aging · 2022
Animal studyOpen access · CC BY8 citationsRead the open copy →
- Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line
Francesco Avolio, Stefano Martinotti, Vladimir Kh. Khavinson et al. · International Journal of Molecular Sciences · 2022
Study in humansOpen access · CC BY20 citationsRead the open copy →
- Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro
Oleg Mikchailovich Ivko, А. О. Дробинцева, Daria Olegovna Leont’eva et al. · Advances in Gerontology · 2021
Open access2 citationsRead the open copy →
- Peptide medicines: past, present, future
V. Kh. Khavinson · Clinical Medicine (Russian Journal) · 2020
Open access · CC BY66 citationsRead the open copy →
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Vladimir Kh. Khavinson, Francesca Diomede, Ekaterina Sergeevna Mironova et al. · Molecules · 2020
Study in humansOpen access · CC BY30 citationsRead the open copy →
- Pineal peptides and their role in ageing
В.Х. Хавинсон, Irina G. Popovich · Nauchno-prakticheskii zhurnal «Patogenez» · 2017
Open access2 citationsRead the open copy →
- Antiproteinuric and nephroprotective activity of some peptide drugs in experimental nephropathy
К. В. Сивак, К. И. Стосман, Т. Н. Саватеева-Любимова et al. · Nauchno-prakticheskii zhurnal «Patogenez» · 2017
Open accessRead the open copy →
- THE CORRECTION OF MELATONIN-PRODUCING FUNCTION VIOLATIONS OF PINEAL GLAND IN ELDERLY PEOPLE WITH SUBSTITUTIVE DOSES OF MELATONIN AND EPIPHYSIS PEPTIDE DRUGS
I. A. Antoniuk-Shcheglova · PROBLEMS OF ENDOCRINE PATHOLOGY · 2013
Open access · CC BYRead the open copy →
Each list shows up to 40 papers.See all 113 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.