Epitalon studies
113 journal papers mention Epitalon in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Epitalon is safe, effective or approved for any use.
- Papers
- 113
- 108 articles, 5 reviews
- Earliest paper
- 1990
- Most papers in 2004 (11)
- Open access
- 24%
- free to read somewhere
- Reviews
- 4%
- of all papers listed
What kind of studies
Of 166 papers in PubMed that mention Epitalon in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials5
- Other clinical trials2
- Meta-analyses and systematic reviews0
- Other reviews19
- Case reports0
- Animal studies only103
- Studies in humans59
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Epitalon in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 1
- Completed
- 0
- Ongoing or planned
- 1
- Phase 1
- 0
- Phase 2
- 0
- Phase 3
- 0
- Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
NCT07888595Enrolling by invitationEarly phase 1started 2026-10-21
The five most recently updated studies. See all 1 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 11 papers in a year. The latest year may still be incomplete.
Where it is published
- Bulletin of Experimental Biology and Medicine42 papers
- Advances in Gerontology7 papers
- Neuroscience and Behavioral Physiology4 papers
- Annals of the New York Academy of Sciences4 papers
- International Journal of Molecular Sciences3 papers
The papers
Most citedName in the title
- Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster
Vladimir Nikolaevich Anisimov, S. V. Mylnikov, Т. И. Опарина et al. · Mechanisms of Ageing and Development · 1997
Animal study55 citations
- Twenty Years of Study on Effects of Pineal Peptide Preparation: Epithalamin in Experimental Gerontology and Oncology
Vladimir Nikolaevich Anisimov, Vladimir Kh. Khavinson, Vjacheslav G. Morozov · Annals of the New York Academy of Sciences · 1994
Review43 citations
- Effect of epitalon on the lifespan increase in Drosophila melanogaster
Vladimir Kh. Khavinson, Dmitry M. Izmaylov, Ludmila K. Obukhova et al. · Mechanisms of Ageing and Development · 2000
Animal study40 citations
- Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats
Vladimir Nikolaevich Anisimov, S. V. Mylnikov, Vladimir Kh. Khavinson · Mechanisms of Ageing and Development · 1998
Animal study40 citations
- Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER‐2/neu transgenic mice
Vladimir Nikolaevich Anisimov, Vladimir Kh. Khavinson, Mauro Provinciali et al. · International Journal of Cancer · 2002
Animal study33 citations
- Effect of Pineal Peptide Preparation (Epithalamin) on Life Span and Pineal and Serum Melatonin Level in Old Rats
Vladimir Nikolaevich Anisimov, Л. А. Бондаренко, Vladimir Kh. Khavinson · Annals of the New York Academy of Sciences · 1992
Animal study33 citations
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Vladimir Kh. Khavinson, Francesca Diomede, Ekaterina Sergeevna Mironova et al. · Molecules · 2020
Study in humansOpen access · CC BY30 citationsRead the open copy →
- Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
Vladimir Kh. Khavinson, I. E. Bondarev, Alexander A. Butyugov · Bulletin of Experimental Biology and Medicine · 2003
Study in humans24 citations
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice
Vladimir Nikolaevich Anisimov, Vladimir Kh. Khavinson, Irina G. Popovich et al. · Biogerontology · 2003
Animal study20 citations
- Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats
Vladimir Nikolaevich Anisimov, Vladimir Kh. Khavinson, Irina G. Popovich et al. · Cancer Letters · 2002
Animal study19 citations
- Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart using DNA-Microarray Technology
Sergey V. Anisimov, K. R. Boheler, Vladimir Kh. Khavinson et al. · Bulletin of Experimental Biology and Medicine · 2002
Animal study19 citations
- Reparative Effect of Epithalon on Pineal Gland Ultrastructure in γ-Irradiated Rats
Vladimir Kh. Khavinson, N. D. Yakovleva, Попучиев Виктор Васильевич et al. · Bulletin of Experimental Biology and Medicine · 2001
Animal study14 citations
- Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa
George Kossoy, Judit Zandbank, Eugenie Tendler et al. · International Journal of Molecular Medicine · 2003
Animal study13 citations
- Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
Nadezhda D. Goncharova, B. Kh. Khavinson, Boris A. Lapin · Bulletin of Experimental Biology and Medicine · 2001
Animal study11 citations
- Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties
Szymon Kamil Araj, Jakub Brzezik, Katarzyna Mądra-Gackowska et al. · International Journal of Molecular Sciences · 2025
ReviewOpen access · CC BY10 citationsRead the open copy →
- Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations
Céline Vanhee, Goedele Moens, Els Van Hoeck et al. · Drug Testing and Analysis · 2014
Study in humans10 citations
- Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice
Svetlana V. Rosenfeld, E. F. Togo, V. S. Mikheev et al. · Bulletin of Experimental Biology and Medicine · 2002
Animal study10 citations
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue Xue, Sai‐Li Liu, Jia-Ni Guo et al. · Aging · 2022
Animal studyOpen access · CC BY8 citationsRead the open copy →
- Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
Safeer Ullah, Zaheer Haider, Chalani Dilshani Perera et al. · Life Sciences · 2025
Animal study7 citations
- Effects of Melatonin and Epithalamin on the Content of Protein and Lipid Peroxidation Products in Rat Cortex and Hippocampus under Conditions of Acute Hypoxia
І. І. Zamorskii, I. Yu. Sopova, Vladimir Kh. Khavinson · Bulletin of Experimental Biology and Medicine · 2012
Animal study7 citations
- Effect of Peptide Preparation Epithalamin on Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Elderly People
Oleg V. Korkushko, Vladimir Kh. Khavinson, V. B. Shatilo et al. · Bulletin of Experimental Biology and Medicine · 2004
Randomized trial6 citations
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Sarah Al-dulaimi, Ross Thomas, Sheila Matta et al. · Biogerontology · 2025
Study in humansOpen access · CC BY5 citationsRead the open copy →
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Marco Gatta, Melania Dovizio, Cristina Milillo et al. · Stem Cell Reviews and Reports · 2025
Study in humansOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging
Vladimir Nikolaevich Anisimov, V. Kh. Khavinsov, Irina N. Alimova et al. · Bulletin of Experimental Biology and Medicine · 2002
Animal study5 citations
- Immunohistochemical and Morphometric Analysis of Effects of Vilon and Epithalon on Functional Morphology of Radiosensitive Organs
Vladimir Kh. Khavinson, Vadim V. Yuzhakov, И. М. Кветной et al. · Bulletin of Experimental Biology and Medicine · 2001
Animal study5 citations
- Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice
Vladimir Nikolaevich Anisimov, Vladimir Kh. Khavinson, Irina N. Alimova et al. · Bulletin of Experimental Biology and Medicine · 2002
Animal study4 citations
- The protective effect of melatonin and epithalon on hypothalamic regulation of the reproductive function in female rats in a model of its premature aging and on the estrous cycles of aging animals in different lighting conditions
Кореневский Андрей Валентинович, Yu. P. Milyutina, A. V. Bukalyov et al. · Advances in Gerontology · 2014
3 citations
- Expression of Argyrophilic Proteins in the Nucleolar Organizer Regions of Human Thymocytes and Thymic Epitheliocytes under Conditions of Coculturing with Vilon and Epithalon Peptides
Н. Т. Райхлин, Букаева Ирина Алексеевна, Е. А. Смирнова et al. · Bulletin of Experimental Biology and Medicine · 2004
Study in humans3 citations
- Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages
Vladimir Kh. Khavinson, M. I. Razumovsky, Svetlana Trofimova et al. · Bulletin of Experimental Biology and Medicine · 2003
Study in humans3 citations
- Increased hypothalamic sensitivity to estrogen inhibition induced by L-dopa, phenytoin, epithalamin, and phenformin in old rats
Vladimir M. Dilman, V. N. Anisimov · Bulletin of Experimental Biology and Medicine · 1975
3 citations
- The statistical significance of the clinical research results on the pineal gland preparation (epithalamin)
Elena Andreevna Vershinina, Г.Л. Сафарова, Irina G. Popovich et al. · Vrach · 2020
2 citations
- Anti-mutagenic action of synthetic “epitalon” peptide in mice with different body colour
S. V. Mylnikov, Natalia Pavlova, Larisa Vladimirovna Barabanova · Ecological genetics · 2011
Open access · CC BY2 citationsRead the open copy →
- Geometric structure of a molecule of Epitalon tetrapeptide: A molecular-dynamics simulation
Ilya V. Rogachevskii, Б. Ф. Щеголев, Vladimir Kh. Khavinson · Russian Journal of General Chemistry · 2006
2 citations
- Effect of Epithalamin on Circadian Relationship between the Endocrine Function of the Thymus and Melatonin-Producing Function of the Pineal Gland in Elderly People
І. F. Labunets, G. M. Butenko, L. V. Magdich et al. · Bulletin of Experimental Biology and Medicine · 2004
Study in humans2 citations
- Effect of Epithalon on Age-Specific Changes in the Retina in Rats with Hereditary Pigmentary Dystrophy
Vladimir Kh. Khavinson, M I Razumovskiĭ, Svetlana Trofimova et al. · Bulletin of Experimental Biology and Medicine · 2002
Animal study2 citations
- Modulating Effects of Epithalamin and Epithalon on the Functional Morphology of the Spleen in Old Pinealectomized Rats
V. Kh. Khavinson, С. С. Коновалов, Vadim V. Yuzhakov et al. · Bulletin of Experimental Biology and Medicine · 2001
Animal study2 citations
- Antimutagenic effects of synthetic epithalon peptide in mice Mus musculus different in hair color
S. V. Mylnikov, N. V. Pavlova, Larisa Vladimirovna Barabanova · Russian Journal of Genetics Applied Research · 2012
1 citations
- Effects of intranasal administration of epitalon on neuron activity in the rat neocortex
Dmitry A. Sibarov, Anna B. Volnova, Dmitrij S. Frolov et al. · Neuroscience and Behavioral Physiology · 2007
Animal study1 citations
- Fluorescent Microscopic Study of Epithalon Binding in Maternal and Fetal Rabbit Tissues in Health and under Conditions of Placental Insufficiency
Elena A. Lapina, L. A. Nazarova, O. P. Petrova et al. · Bulletin of Experimental Biology and Medicine · 2005
Animal study1 citations
- The Pineal Peptide Preparation, Epithalamin, Slows Aging in Drosophila melanogaster, Mice, and Rats
Vladimir Nikolaevich Anisimov, S. V. Mylnikov, Vladimir Kh. Khavinson · Annals of the New York Academy of Sciences · 1998
1 citations
LatestName in title or abstract
- Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence
Ankur Jain, David M. Gallacher, Mohammed A. Issa et al. · International Journal of Molecular Sciences · 2026
ReviewOpen access · CC BYRead the open copy →
- The peptide boom: a critical appraisal of evidence, patient safety risks, and regulatory failure in the experimental wellness peptide market
Giorgi Pkhakadze · Georgian Medical Journal · 2026
Open access · CC BYRead the open copy →
- The microgram hypothesis: a translational dosing error in Epitalon peptide research and its implications for human aging application
Chang-Hun Jung · Aging Pathobiology and Therapeutics · 2026
Open access · CC BY-NC-SARead the open copy →
- PEPTIDE BIOREGULATORS, AGING AND HUMAN LONGEVITY: EPITHALON, THYMALIN, THYMOGEN, DSIP, VILON AND VESUGEN IN CIRCADIAN BIOLOGY, TELOMERASE REGULATION AND INFLAMMAGING
Luiz Felippe Mendes Caquetti · INTERNATIONAL BLEST SCIENTIFIC · 2026
Open accessRead the open copy →
- LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma
Yue Zhang, Siyu Qian, Qing Yang et al. · Cell Death and Disease · 2026
Study in humansOpen access · CC BY1 citationsRead the open copy →
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Omar F. Rahman, Steven J. Lee, William A. Seeds · JAAOS Global Research and Reviews · 2026
ReviewOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Effects of short peptides on the molecular mechanisms of aging in laboratory primates
S. V. Trofimova, T.G. Kuznetsova, A. V. Trofimov · Molekulyarnaya Meditsina (Molecular medicine) · 2025
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Sarah Al-dulaimi, Ross Thomas, Sheila Matta et al. · Biogerontology · 2025
Study in humansOpen access · CC BY5 citationsRead the open copy →
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Marco Gatta, Melania Dovizio, Cristina Milillo et al. · Stem Cell Reviews and Reports · 2025
Study in humansOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties
Szymon Kamil Araj, Jakub Brzezik, Katarzyna Mądra-Gackowska et al. · International Journal of Molecular Sciences · 2025
ReviewOpen access · CC BY10 citationsRead the open copy →
- Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
Safeer Ullah, Zaheer Haider, Chalani Dilshani Perera et al. · Life Sciences · 2025
Animal study7 citations
- Bioactive Anti-Aging Substances: Geroprotectors
Anna Fokina, Anna Dmitrievna Vesnina, Anna Sergeevna Frolova et al. · Food Processing Techniques and Technology · 2024
Open access · CC BY8 citationsRead the open copy →
- Improving Biological Age, Telomere Length, and Cognition: A Case Report on the Use of Therapeutic Plasma Exchange, Peptides, Umbilical Cord Tissue Mesenchymal Stem Cells and Exosomes in a Patient with Cognitive Decline
Edwin Ho Ming Lee, Morgan Burns · Journal of Restorative Medicine · 2024
Open access1 citationsRead the open copy →
- The influence of peptide bioregulators on the resistance of the organism to adverse effects
Aleksey E. Kim · Reviews on Clinical Pharmacology and Drug Therapy · 2023
- Epigenetic Variations in Chromatin Caused by the Combination of Bioregulators with Heavy Metals During Aging
T Lezhava, Tinatin Jokhadze, Jamlet Monaselidze et al. · International Journal of Peptide Research and Therapeutics · 2022
2 citations
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue Xue, Sai‐Li Liu, Jia-Ni Guo et al. · Aging · 2022
Animal studyOpen access · CC BY8 citationsRead the open copy →
- Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line
Francesco Avolio, Stefano Martinotti, Vladimir Kh. Khavinson et al. · International Journal of Molecular Sciences · 2022
Study in humansOpen access · CC BY20 citationsRead the open copy →
- Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro
Oleg Mikchailovich Ivko, А. О. Дробинцева, Daria Olegovna Leont’eva et al. · Advances in Gerontology · 2021
Open access2 citationsRead the open copy →
- THE INFLUENCE OF AND PEPTIDES ON MITOCHONDRIES STAIN AND L7A RIBOSOMES PROTEIN EXPRESSION DURING HUMAN PINEAL GLAND AND THYMUS CELL SENESCENCE
Oleg Mikchailovich Ivko, А. О. Дробинцева, Daria Olegovna Leont’eva et al. · Успехи геронтологии · 2020
1 citations
- Peptide medicines: past, present, future
V. Kh. Khavinson · Clinical Medicine (Russian Journal) · 2020
Open access · CC BY66 citationsRead the open copy →
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Vladimir Kh. Khavinson, Francesca Diomede, Ekaterina Sergeevna Mironova et al. · Molecules · 2020
Study in humansOpen access · CC BY30 citationsRead the open copy →
- The statistical significance of the clinical research results on the pineal gland preparation (epithalamin)
Elena Andreevna Vershinina, Г.Л. Сафарова, Irina G. Popovich et al. · Vrach · 2020
2 citations
- Pineal peptides and their role in ageing
В.Х. Хавинсон, Irina G. Popovich · Nauchno-prakticheskii zhurnal «Patogenez» · 2017
Open access2 citationsRead the open copy →
- Antiproteinuric and nephroprotective activity of some peptide drugs in experimental nephropathy
К. В. Сивак, К. И. Стосман, Т. Н. Саватеева-Любимова et al. · Nauchno-prakticheskii zhurnal «Patogenez» · 2017
Open accessRead the open copy →
- Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions
A. V. Morozov, Евгений Александрович Хижкин, E. B. Svechkina et al. · Bulletin of Experimental Biology and Medicine · 2015
Animal study3 citations
- Peptides and CCL11 and HMGB1 as molecular markers of aging: Literature review and own data
Vladimir Kh. Khavinson, Kuznik Bi, Svetlana I. Tarnovskaya et al. · Advances in Gerontology · 2015
Review8 citations
- Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations
Céline Vanhee, Goedele Moens, Els Van Hoeck et al. · Drug Testing and Analysis · 2014
Study in humans10 citations
- Peptide bioregulators: A new class of geroprotectors, report 2. The results of clinical trials
Vladimir Kh. Khavinson, Kuznik Bi, Galina Anatol’evna Ryzhak · Advances in Gerontology · 2014
12 citations
- Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides
І. І. Zamorskii, T. S. Shchudrova · BIOPHYSICS · 2014
Animal study10 citations
- The protective effect of melatonin and epithalon on hypothalamic regulation of the reproductive function in female rats in a model of its premature aging and on the estrous cycles of aging animals in different lighting conditions
Кореневский Андрей Валентинович, Yu. P. Milyutina, A. V. Bukalyov et al. · Advances in Gerontology · 2014
3 citations
- THE CORRECTION OF MELATONIN-PRODUCING FUNCTION VIOLATIONS OF PINEAL GLAND IN ELDERLY PEOPLE WITH SUBSTITUTIVE DOSES OF MELATONIN AND EPIPHYSIS PEPTIDE DRUGS
I. A. Antoniuk-Shcheglova · PROBLEMS OF ENDOCRINE PATHOLOGY · 2013
Open access · CC BYRead the open copy →
- Melatonin and Pineal Gland Peptides Are Able to Correct the Impairment of Reproductive Cycles in Rats
Alexander V. Arutjunyan, Ljudmila Kozina, Yu. P. Milyutina et al. · Current Aging Science · 2013
Animal study4 citations
- Effects of Melatonin and Epithalamin on the Content of Protein and Lipid Peroxidation Products in Rat Cortex and Hippocampus under Conditions of Acute Hypoxia
І. І. Zamorskii, I. Yu. Sopova, Vladimir Kh. Khavinson · Bulletin of Experimental Biology and Medicine · 2012
Animal study7 citations
- Antimutagenic effects of synthetic epithalon peptide in mice Mus musculus different in hair color
S. V. Mylnikov, N. V. Pavlova, Larisa Vladimirovna Barabanova · Russian Journal of Genetics Applied Research · 2012
1 citations
- Morphofunctional and molecular bases of pineal gland aging
Vladimir Kh. Khavinson, Natalia Sergeevna Linkova · Human Physiology · 2012
Review11 citations
- Peptidegic Stimulation of Differentiation of Pineal Immune Cells
Natalia Sergeevna Linkova, Vladimir Kh. Khavinson, Natalia Iosifovna Chalisova et al. · Bulletin of Experimental Biology and Medicine · 2011
Animal study4 citations
- Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
Larisa Ivanovna Fedoreyeva, Igor I. Kireev, Vladimir Kh. Khavinson et al. · Biochemistry (Moscow) · 2011
Study in humans64 citations
- Specific features in the pineal gland-thymus relationships during aging
Natalia Sergeevna Linkova, Victoria Olegovna Polyakova, И. М. Кветной et al. · Advances in Gerontology · 2011
4 citations
- The influence of pineal factors on the bone marrow cell profile in animals of different ages during changes of the thymus functional condition
І. F. Labunets, Anzhela E. Rodnichenko, G. M. Butenko · Advances in Gerontology · 2011
4 citations
Each list shows up to 40 papers.See all 113 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.