BPC-157 studies
300 journal papers mention BPC-157 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether BPC-157 is safe, effective or approved for any use.
- Papers
- 300
- 265 articles, 35 reviews
- Earliest paper
- 1988
- Most papers in 2026 (35)
- Open access
- 47%
- free to read somewhere
- Reviews
- 12%
- of all papers listed
What kind of studies
Of 229 papers in PubMed that mention BPC-157 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials0
- Other clinical trials0
- Meta-analyses and systematic reviews1
- Other reviews52
- Case reports1
- Animal studies only107
- Studies in humans55
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention BPC-157 in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 4
- Completed
- 1
- Ongoing or planned
- 2
- Phase 1
- 2
- Phase 2
- 1
- Phase 3
- 0
- Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery
NCT07803250Not yet recruitingPhase 1started 2027-01-01
- A Clinical Trial to Evaluate the Effects of Peptide Gummies on Markers of Inflammation, Physical Performance, and Recovery
NCT07752381Completedstarted 2025-09-01
- BPC 157 for Acute Hamstring Muscle Strain Repair
NCT07437547RecruitingPhase 2started 2026-02-02
- PCO-02 - Safety and Pharmacokinetics Trial
NCT02637284Status unknownPhase 1started 2015-10
The five most recently updated studies. See all 4 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 35 papers in a year. The latest year may still be incomplete.
Where it is published
- The FASEB Journal46 papers
- Pharmaceuticals21 papers
- Gastroenterology17 papers
- Journal of Physiology-Paris16 papers
- European Journal of Pharmacology16 papers
The papers
Most citedName in the title
- Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
Predrag Sikirić, Sven Seiwerth, Rudolf Ručman et al. · Current Neuropharmacology · 2016
ReviewOpen access59 citationsRead the open copy →
- BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection
Jong-Min Park, Ho Jae Lee, Predrag Sikirić et al. · Current Pharmaceutical Design · 2020
Review51 citations
LatestName in title or abstract
- Regenerative peptides for inferior alveolar nerve injury: a narrative review
Scott H. Froum, Nathan E. Estrin, Gianna Pico et al. · Frontiers in Dental Medicine · 2026
ReviewOpen access · CC BYRead the open copy →
- Possibilities for Cytoprotective Liver Therapy, Stable Gastric Pentadecapeptide BPC 157, and Standard Agents—A Narrative Review
Marko Sever, Anita Zenko Sever, Robert Kliček et al. · Pharmaceuticals · 2026
ReviewOpen access · CC BYRead the open copy →
- Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety
J.T. POOLTON, J. MINETT, A. KAZMI · Acta Orthopaedica Belgica · 2026
Systematic reviewOpen accessRead the open copy →
- Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases
Scott H. Froum, Nathan E. Estrin, Gianna Pico et al. · Frontiers in Oral Health · 2026
Case reportOpen access · CC BYRead the open copy →
- BPC 157 in Rodent Ischemia–Reperfusion Injury: A Critical Review of Preclinical Evidence
Hüseyin Demirtaş · International Journal of Molecular Sciences · 2026
ReviewOpen access · CC BYRead the open copy →
- Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management
Choopong Luansritisakul, Monping Chiang, Stacey L. Burns et al. · Current Pain and Headache Reports · 2026
Review
- BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers
Diana-Maria Mateescu, Dragos-Mihai Gavrilescu, Florin Eugen Constantinescu et al. · Pharmaceutics · 2026
ReviewOpen access · CC BY3 citationsRead the open copy →
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management
Claire Yuan, Ariana M. DeMers, Victor M. Silva-Ortiz et al. · International Journal of Molecular Sciences · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics
Predrag Sikirić, Ivan Barišić, Mario Udovičić et al. · Pharmaceuticals · 2026
ReviewOpen access · CC BY2 citationsRead the open copy →
- Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157—A Review
Danijel Matek, Irena Matek, Mladen Japjec et al. · Pharmaceuticals · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- Conventional Antiarrhythmics Class I–IV, Late INa Inhibitors, IKs Enhancers, RyR2 Stabilizers, Gap Junction Modulators, Atrial-Selective Antiarrhythmics, and Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Therapy in Arrhythmias
Predrag Sikirić, Ivan Barišić, Mario Udovičić et al. · Pharmaceuticals · 2026
ReviewOpen access · CC BY4 citationsRead the open copy →
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Omar F. Rahman, Steven J. Lee, William A. Seeds · JAAOS Global Research and Reviews · 2026
ReviewOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the “Triad” of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy
Sanja Masnec, Antonio Kokot, Tamara Kralj et al. · Pharmaceuticals · 2025
ReviewOpen access · CC BY3 citationsRead the open copy →
- Application of peptide therapy for ligaments and tendons: A narrative review
Grace Kim, WILLIAM H. FANG, Justin Chung et al. · Journal of Orthopaedic Reports · 2025
ReviewOpen access · CC BY2 citationsRead the open copy →
Each list shows up to 40 papers.See all 300 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:31 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.