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BPC-157 studies

300 journal papers mention BPC-157 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.

Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether BPC-157 is safe, effective or approved for any use.

Compare BPC-157 prices, from €13.99 →

Papers
300
265 articles, 35 reviews
Earliest paper
1988
Most papers in 2026 (35)
Open access
47%
free to read somewhere
Reviews
12%
of all papers listed

What kind of studies

Of 229 papers in PubMed that mention BPC-157 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.

  • Randomized controlled trials0
  • Other clinical trials0
  • Meta-analyses and systematic reviews1
  • Other reviews52
  • Case reports1
  • Animal studies only107
  • Studies in humans55

Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).

Registered clinical studies

Studies on ClinicalTrials.gov that mention BPC-157 in their intervention details. A registration says a study is planned or running, not what it found.

Registered
4
Completed
1
Ongoing or planned
2
Phase 1
2
Phase 2
1
Phase 3
0
  1. Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery

    NCT07803250Not yet recruitingPhase 1started 2027-01-01

  2. A Clinical Trial to Evaluate the Effects of Peptide Gummies on Markers of Inflammation, Physical Performance, and Recovery

    NCT07752381Completedstarted 2025-09-01

  3. BPC 157 for Acute Hamstring Muscle Strain Repair

    NCT07437547RecruitingPhase 2started 2026-02-02

  4. PCO-02 - Safety and Pharmacokinetics Trial

    NCT02637284Status unknownPhase 1started 2015-10

The five most recently updated studies. See all 4 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.

Papers per year

1997 to 2026, peak 35 papers in a year. The latest year may still be incomplete.

1997: 7 papers1998: 3 papers1999: 8 papers2000: 4 papers2001: 8 papers2002: 0 papers2003: 4 papers2004: 5 papers2005: 3 papers2006: 4 papers2007: 2 papers2008: 4 papers2009: 3 papers2010: 5 papers2011: 8 papers2012: 4 papers2013: 8 papers2014: 17 papers2015: 12 papers2016: 11 papers2017: 19 papers2018: 12 papers2019: 19 papers2020: 12 papers2021: 17 papers2022: 15 papers2023: 19 papers2024: 6 papers2025: 15 papers2026: 35 papers19972026

Where it is published

  1. The FASEB Journal46 papers
  2. Pharmaceuticals21 papers
  3. Gastroenterology17 papers
  4. Journal of Physiology-Paris16 papers
  5. European Journal of Pharmacology16 papers

The papers

ShowAllOpen accessReviews

Most citedName in the title

  1. Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

    Chung-Hsun Chang, Wen‐Chung Tsai, Ya-Hui Hsu et al. · Molecules · 2014

    Animal studyOpen access · CC BY88 citationsRead the open copy →

  2. Doxorubicine-Congestive Heart Failure-Increased Big Endothelin-1 Plasma Concentration: Reversal by Amlodipine, Losartan, and Gastric Pentadecapeptide BPC157 in Rat and Mouse

    Martina Lovrić Benčić, Predrag Sikirić, Jadranka Šeparović Hanževački et al. · Journal of Pharmacological Sciences · 2004

    Animal studyOpen access79 citationsRead the open copy →

  3. Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine

    Mirjana Stupnišek, Antonio Kokot, Domagoj Drmić et al. · PLoS ONE · 2015

    Animal studyOpen access · CC BY68 citationsRead the open copy →

  4. Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157

    Mario Starešinić, Igor Petrović, Tomislav Novinščak et al. · Journal of Orthopaedic Research® · 2006

    Animal studyOpen access68 citationsRead the open copy →

  5. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights

    Antonija Ðuzel, Josipa Vlainić, Marko Antunović et al. · World Journal of Gastroenterology · 2017

    Study in humansOpen access · CC BY-NC62 citationsRead the open copy →

  6. Achilles Detachment in Rat and Stable Gastric Pentadecapeptide BPC 157: Promoted Tendon‐to‐Bone Healing and Opposed Corticosteroid Aggravation

    Andrija Krivić, Tomislav Anić, Sven Seiwerth et al. · Journal of Orthopaedic Research® · 2006

    Animal studyOpen access60 citationsRead the open copy →

  7. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications

    Predrag Sikirić, Sven Seiwerth, Rudolf Ručman et al. · Current Neuropharmacology · 2016

    ReviewOpen access59 citationsRead the open copy →

  8. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway

    Ming‐Jer Hsieh, Cheng-Hung Lee, Ho-Yen Chueh et al. · Scientific Reports · 2020

    Animal studyOpen access · CC BY58 citationsRead the open copy →

  9. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

    Domagoj Drmić, Danijela Kolenc, Spomenko Ilić et al. · World Journal of Gastroenterology · 2017

    Study in humansOpen access · CC BY-NC52 citationsRead the open copy →

LatestName in title or abstract

  1. Regenerative peptides for inferior alveolar nerve injury: a narrative review

    Scott H. Froum, Nathan E. Estrin, Gianna Pico et al. · Frontiers in Dental Medicine · 2026

    ReviewOpen access · CC BYRead the open copy →

  2. Possibilities for Cytoprotective Liver Therapy, Stable Gastric Pentadecapeptide BPC 157, and Standard Agents—A Narrative Review

    Marko Sever, Anita Zenko Sever, Robert Kliček et al. · Pharmaceuticals · 2026

    ReviewOpen access · CC BYRead the open copy →

  3. Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety

    J.T. POOLTON, J. MINETT, A. KAZMI · Acta Orthopaedica Belgica · 2026

    Systematic reviewOpen accessRead the open copy →

  4. Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases

    Scott H. Froum, Nathan E. Estrin, Gianna Pico et al. · Frontiers in Oral Health · 2026

    Case reportOpen access · CC BYRead the open copy →

  5. BPC 157 in Rodent Ischemia–Reperfusion Injury: A Critical Review of Preclinical Evidence

    Hüseyin Demirtaş · International Journal of Molecular Sciences · 2026

    ReviewOpen access · CC BYRead the open copy →

  6. Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis

    Hanchao Zhang, Lanying Shao, Qinghua Feng et al. · Applied Biochemistry and Biotechnology · 2026

    Animal studyOpen access · CC BYRead the open copy →

  7. The peptide boom: a critical appraisal of evidence, patient safety risks, and regulatory failure in the experimental wellness peptide market

    Giorgi Pkhakadze · Georgian Medical Journal · 2026

    Open access · CC BYRead the open copy →

  8. Peptide Supplements and Their Therapeutic Applications in Sports Medicine

    Kushagra Tewari, Timothy P. Liu, Christina Im et al. · The American Journal of Sports Medicine · 2026

    Open access · CC BY1 citationsRead the open copy →

  9. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study

    Ozancan Biçer, Oktay Adanır, Yiğit Güleryüz et al. · Joint Diseases and Related Surgery · 2026

    Animal studyOpen access · CC BY-NCRead the open copy →

  10. BPC-157 in sports medicine: regenerative potential, clinical evidence and anti-doping challenges

    Raydel Pérez Castillo · MOJ Sports Medicine · 2026

    Open access · CC BY-NCRead the open copy →

  11. Fabrication and characterization of biocompatible BPC-157 based chitosan hydrogel

    Arunim, Monika Dagar, Misika Solanki et al. · 3 Biotech · 2026

    Open accessRead the open copy →

  12. Peptides

    Farboud Aria, Param Shah, Sean Omoseni et al. · JBJS Journal of Orthopaedics for Physician Assistants · 2026

    Open access · CC BY-NC-NDRead the open copy →

  13. Emerging Peptide Therapies in Orthopaedics: Evidence, Safety, and Perioperative Implications

    Ahmed Siddiqi, Khalid Yousuf, Paul B. Jacob · Journal of Orthopaedic Experience & Innovation · 2026

    Open access · CC BY-NC-NDRead the open copy →

  14. REGENERATIVE PEPTIDES IN MUSCULOSKELETAL MEDICINE: COMPARATIVE MECHANISMS OF BPC-157, THYMOSIN BETA-4/TB-500, TB-500 FRAGMENT AND KPV IN OSTEOMYOARTICULAR REPAIR

    Luiz Felippe Mendes Caquetti · INTERNATIONAL BLEST SCIENTIFIC · 2026

    Open accessRead the open copy →

  15. BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase

    Juliana Jelińska, Michalina Józwiak, Łukasz Szeleszczuk et al. · International Journal of Molecular Sciences · 2026

    Study in humansOpen access · CC BY1 citationsRead the open copy →

  16. Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats—A Cytoprotection Approach

    Ivan Maria Smoday, Vlasta Vuković, Katarina Oroz et al. · Pharmaceuticals · 2026

    Open access · CC BY1 citationsRead the open copy →

  17. Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury

    Alperen Kutay Yıldırım, Hüseyin Demirtaş, Abdullah Özer et al. · Scientific Reports · 2026

    Animal studyOpen access · CC BY-NC-ND2 citationsRead the open copy →

  18. BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers

    Diana-Maria Mateescu, Dragos-Mihai Gavrilescu, Florin Eugen Constantinescu et al. · Pharmaceutics · 2026

    ReviewOpen access · CC BY3 citationsRead the open copy →

  19. Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery

    Alperen Kutay Yıldırım, Ahmet Onur Daştan, Meriç DEMELİ ERTUŞ et al. · Journal of Clinical Medicine · 2026

    Open access · CC BY1 citationsRead the open copy →

  20. BPC-157 and GHK-Cu in Wound Healing and Tissue Repair: A Review of Clinical Efficacy and Safety

    Olaf Wojcieszuk, Łukasz Starczewski, Adrianna Babik et al. · Quality in Sport · 2026

    Open access · CC BY-NC-SA2 citationsRead the open copy →

  21. Therapeutic peptides in gerontology: mechanisms and applications for healthy aging

    Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026

    ReviewOpen access · CC BY5 citationsRead the open copy →

  22. From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management

    Claire Yuan, Ariana M. DeMers, Victor M. Silva-Ortiz et al. · International Journal of Molecular Sciences · 2026

    ReviewOpen access · CC BY5 citationsRead the open copy →

  23. Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics

    Predrag Sikirić, Ivan Barišić, Mario Udovičić et al. · Pharmaceuticals · 2026

    ReviewOpen access · CC BY2 citationsRead the open copy →

  24. Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157—A Review

    Danijel Matek, Irena Matek, Mladen Japjec et al. · Pharmaceuticals · 2026

    ReviewOpen access · CC BY5 citationsRead the open copy →

  25. BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1

    Jieyu Zhang, Mengmeng Liu, Huihui Ou et al. · Cell Communication and Signaling · 2026

    Study in humansOpen access · CC BY-NC-ND3 citationsRead the open copy →

  26. Conventional Antiarrhythmics Class I–IV, Late INa Inhibitors, IKs Enhancers, RyR2 Stabilizers, Gap Junction Modulators, Atrial-Selective Antiarrhythmics, and Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Therapy in Arrhythmias

    Predrag Sikirić, Ivan Barišić, Mario Udovičić et al. · Pharmaceuticals · 2026

    ReviewOpen access · CC BY4 citationsRead the open copy →

  27. BPC-157 and the gut–brain axis: emerging links between cytoprotection and neuroregeneration

    Barbara Pietrzyk, Marek Waluga · Annales Academiae Medicae Silesiensis · 2026

    Open access · CC BY-SARead the open copy →

  28. Fourier Transform Infrared Spectroscopic Characterization of Aortic Wall Remodeling by Stable Gastric Pentadecapeptide BPC 157 After Unilateral Adrenalectomy in Rats

    Ivan Maria Smoday, Vlasta Vuković, Katarina Oroz et al. · Pharmaceuticals · 2026

    Open access · CC BY3 citationsRead the open copy →

  29. Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System—Triple NO-Agent Approach in Rats

    Goran Madžarac, Tomislav Bečejac, Toni Penović et al. · Pharmaceuticals · 2026

    Open access · CC BY2 citationsRead the open copy →

  30. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

    Omar F. Rahman, Steven J. Lee, William A. Seeds · JAAOS Global Research and Reviews · 2026

    ReviewOpen access · CC BY-NC-ND5 citationsRead the open copy →

  31. Thermal Therapies and Peptide Signaling in Women’s Health: A Systems-Based Review

    Noelle L. Cutter, Lenor Nachef, Lennard Goetze et al. · Open Journal of Regenerative Medicine · 2026

    Open access · CC BYRead the open copy →

  32. "СІРА ЗОНА" ФАРМАКОЛОГІЇ: ОГЛЯД ПЕПТИДНИХ БІОРЕГУЛЯТОРІВ ДЛЯ ВІДНОВЛЕННЯ ПІСЛЯ СПОРТИВНИХ ТРАВМ (BPC-157, TB-500)

    А. В. Чорномидз, М. П. Кланца · Physical Culture and Sport Scientific Perspective · 2025

    Open access · CC BYRead the open copy →

  33. Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the “Triad” of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy

    Sanja Masnec, Antonio Kokot, Tamara Kralj et al. · Pharmaceuticals · 2025

    ReviewOpen access · CC BY3 citationsRead the open copy →

  34. (197) Peptides in Practice: Evaluating Efficacy and Safety in Men’s Health

    R Arora, Arjun K. Venkatesh, Gene Austin Krishingner et al. · The Journal of Sexual Medicine · 2025

    Open accessRead the open copy →

  35. Application of peptide therapy for ligaments and tendons: A narrative review

    Grace Kim, WILLIAM H. FANG, Justin Chung et al. · Journal of Orthopaedic Reports · 2025

    ReviewOpen access · CC BY2 citationsRead the open copy →

  36. BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide’s Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on Józwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review. Pharmaceuticals 2025, 18, 185

    Predrag Sikirić, Sven Seiwerth, Anita Škrtić et al. · Pharmaceuticals · 2025

    Open access · CC BY6 citationsRead the open copy →

Each list shows up to 40 papers.See all 300 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:31 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.