Melanotan I studies
156 journal papers mention Melanotan I in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Melanotan I is safe, effective or approved for any use.
- Papers
- 156
- 126 articles, 30 reviews
- Earliest paper
- 1995
- Most papers in 2024 (17)
- Open access
- 50%
- free to read somewhere
- Reviews
- 19%
- of all papers listed
What kind of studies
Of 121 papers in PubMed that mention Melanotan I in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials4
- Other clinical trials8
- Meta-analyses and systematic reviews3
- Other reviews48
- Case reports7
- Animal studies only4
- Studies in humans85
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Melanotan I in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 23
- Completed
- 18
- Ongoing or planned
- 1
- Phase 1
- 4
- Phase 2
- 13
- Phase 3
- 6
- Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria Patients
NCT06388642CompletedPhase 1 / Phase 2started 2024-03-07
- A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo
NCT06109649Active, not recruitingPhase 3started 2023-10-11
- Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Variegate Porphyria (VP)
NCT05854784CompletedPhase 2started 2023-03-28
- Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV)
NCT04525157CompletedPhase 2started 2014-06-06
- A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V
NCT05370235Status unknownPhase 2started 2022-03-28
The five most recently updated studies. See all 23 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 17 papers in a year. The latest year may still be incomplete.
Where it is published
- British Journal of Dermatology8 papers
- Journal of the American Academy of Dermatology7 papers
- Reactions Weekly6 papers
- JAMA Dermatology5 papers
- Clinical and Experimental Dermatology4 papers
The papers
Most citedName in the title
- Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders
Elisabeth Irene Minder, Jasmin Barman‐Aksözen, Xiaoye Schneider‐Yin · Clinical Pharmacokinetics · 2017
Review65 citations
- Advances in the management of erythropoietic protoporphyria – role of afamelanotide
Ashley R. Lane, Jerome T. McKay, Herbert L. Bonkovsky · The Application of Clinical Genetics · 2016
ReviewOpen access · CC BY-NC27 citationsRead the open copy →
- Afamelanotide (CUV1647) in dermal phototoxicity of erythropoietic protoporphyria
Elisabeth Irene Minder, Xiaoye Schneider‐Yin · Expert Review of Clinical Pharmacology · 2014
Review24 citations
- Afamelanotide in protoporphyria and other skin diseases: a review
Adriana Polańska, Joanna Wegner, Paula Nutbohm et al. · Advances in Dermatology and Allergology · 2024
ReviewOpen access9 citationsRead the open copy →
LatestName in title or abstract
- A Review of Randomized Controlled Trials for Vitiligo Therapies Published Between 2013 and 2023
Natalia Maverakis, Zachary J Jaeger, Delphine J. Lee · Cureus · 2026
ReviewOpen access · CC BYRead the open copy →
- New and currently investigated pharmacotherapies for the erythropoietic protoporphyrias: spotlight on dersimelagon and bitopertin
Jasmin Barman‐Aksözen, Francesca Granata, Sebastian Wäscher et al. · Expert Opinion on Pharmacotherapy · 2026
ReviewOpen access · CC BY-NC-NDRead the open copy →
- Hormone und Hautpigmentierung – Grundlagen und klinische Relevanz
Markus Böhm · Die Dermatologie · 2026
Review1 citations
- Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases
Mainak Bardhan, Ayush Anand, Amaan Javed et al. · Diseases · 2025
ReviewOpen access · CC BY5 citationsRead the open copy →
- Treatment advances in Vitiligo: An Updated Review
Ishrat Binti Ismail, Yasmeen Jabeen Bhat, Mohd Shurjeel Ul Islam · Dermatology Practical & Conceptual · 2025
ReviewOpen access · CC BY-NC15 citationsRead the open copy →
- Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management
Anna‐Elisabeth Minder, Louisa G. Kluijver, Jasmin Barman‐Aksözen et al. · Liver International · 2024
ReviewOpen access · CC BY27 citationsRead the open copy →
- A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligo
Alireza Jafarzadeh, Arash Pour Mohammad, Mina Khosravi et al. · Skin Research and Technology · 2024
Systematic reviewOpen access · CC BY30 citationsRead the open copy →
Each list shows up to 40 papers.See all 156 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:27 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.