Melanotan I studies
156 journal papers mention Melanotan I in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Melanotan I is safe, effective or approved for any use.
- Papers
- 156
- 126 articles, 30 reviews
- Earliest paper
- 1995
- Most papers in 2024 (17)
- Open access
- 50%
- free to read somewhere
- Reviews
- 19%
- of all papers listed
What kind of studies
Of 121 papers in PubMed that mention Melanotan I in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials4
- Other clinical trials8
- Meta-analyses and systematic reviews3
- Other reviews48
- Case reports7
- Animal studies only4
- Studies in humans85
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Melanotan I in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 23
- Completed
- 18
- Ongoing or planned
- 1
- Phase 1
- 4
- Phase 2
- 13
- Phase 3
- 6
- Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria Patients
NCT06388642CompletedPhase 1 / Phase 2started 2024-03-07
- A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo
NCT06109649Active, not recruitingPhase 3started 2023-10-11
- Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Variegate Porphyria (VP)
NCT05854784CompletedPhase 2started 2023-03-28
- Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV)
NCT04525157CompletedPhase 2started 2014-06-06
- A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V
NCT05370235Status unknownPhase 2started 2022-03-28
The five most recently updated studies. See all 23 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 17 papers in a year. The latest year may still be incomplete.
Where it is published
- British Journal of Dermatology8 papers
- Journal of the American Academy of Dermatology7 papers
- Reactions Weekly6 papers
- JAMA Dermatology5 papers
- Clinical and Experimental Dermatology4 papers
The papers
Most citedName in the title
- Afamelanotide for Erythropoietic Protoporphyria
Janneke G. Langendonk, Manisha Balwani, Karl E. Anderson et al. · New England Journal of Medicine · 2015
Randomized trialOpen access282 citationsRead the open copy →
- Afamelanotide and Narrowband UV-B Phototherapy for the Treatment of Vitiligo
Henry W. Lim, Pearl E. Grimes, Oma N. Agbai et al. · JAMA Dermatology · 2014
Randomized trialOpen access184 citationsRead the open copy →
- Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria
Gianfranco Biolcati, E. Marchesini, Fiammetta Sorge et al. · British Journal of Dermatology · 2014
Study in humansOpen access · CC BY-NC-ND102 citationsRead the open copy →
- Association of Afamelanotide With Improved Outcomes in Patients With Erythropoietic Protoporphyria in Clinical Practice
Debby Wensink, Margreet A. E. M. Wagenmakers, Jasmin Barman‐Aksözen et al. · JAMA Dermatology · 2020
Study in humansOpen access49 citationsRead the open copy →
- Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria
Debby Wensink, Margreet A. E. M. Wagenmakers, Janneke G. Langendonk · Expert Review of Clinical Pharmacology · 2021
ReviewOpen access · CC BY-NC-ND43 citationsRead the open copy →
- Increased phototoxic burn tolerance time and quality of life in patients with erythropoietic protoporphyria treated with afamelanotide – a three years observational study
Jasmin Barman‐Aksözen, Michèle Nydegger, Xiaoye Schneider‐Yin et al. · Orphanet Journal of Rare Diseases · 2020
Study in humansOpen access · CC BY31 citationsRead the open copy →
- Advances in the management of erythropoietic protoporphyria – role of afamelanotide
Ashley R. Lane, Jerome T. McKay, Herbert L. Bonkovsky · The Application of Clinical Genetics · 2016
ReviewOpen access · CC BY-NC27 citationsRead the open copy →
- Erythropoietic protoporphyria in the Netherlands: Clinical features, psychosocial impact and the effect of afamelanotide
Debby Wensink, Margreet A. E. M. Wagenmakers, J.H.P. Wilson et al. · The Journal of Dermatology · 2022
Study in humansOpen access · CC BY14 citationsRead the open copy →
- Afamelanotide in protoporphyria and other skin diseases: a review
Adriana Polańska, Joanna Wegner, Paula Nutbohm et al. · Advances in Dermatology and Allergology · 2024
ReviewOpen access9 citationsRead the open copy →
- Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria
Anna‐Elisabeth Minder, Xiaoye Schneider‐Yin, Henryk Zulewski et al. · Life · 2023
Open access · CC BY8 citationsRead the open copy →
- Beyond pigmentation: signs of liver protection during afamelanotide treatment in Swiss patients with erythropoietic protoporphyria, an observational study
Anna‐Elisabeth Minder, Jasmin Barman‐Aksözen, Mathias Schmid et al. · Therapeutic Advances in Rare Disease · 2021
Open access · CC BY-NC8 citationsRead the open copy →
- Pseudoleucoderma After Injections of Afamelanotide in a Patient with Atopic Dermatitis
W. von Bartenwerffer, G Siebenhaar, N Hunzelmann · Acta Dermato Venereologica · 2011
Case reportOpen access · CC BY-NC8 citationsRead the open copy →
- German Cohort Observational Study to Investigate the Short‐ and Long‐Term Safety and Clinical Effectiveness of Afamelanotide 16 mg ( SCENESSE ) in Patients With Erythropoietic Protoporphyria ( EPP )
Bernhard Homey, Kathrin Schelonke, C Schlegel et al. · Photodermatology Photoimmunology & Photomedicine · 2025
Study in humansOpen access · CC BY-NC-ND7 citationsRead the open copy →
- Afamelanotide for Treatment of the Protoporphyrias: Impact on Quality of Life and Laboratory Parameters in a US Cohort
Rebecca Karp Leaf, Hetanshi Naik, Paul Yanning Jiang et al. · Life · 2024
Open access · CC BY6 citationsRead the open copy →
- The effects of cholecalciferol and afamelanotide on vitamin D levels in erythropoietic protoporphyria: a multicentre cohort study
Louisa G. Kluijver, Mitra Nekouei Shahraki, Margreet A.E.M. Wagenmakers et al. · British Journal of Dermatology · 2024
Study in humansOpen access · CC BY4 citationsRead the open copy →
- A feasibility and safety study of afamelanotide in acute stroke patients – an open label, proof of concept, phase iia clinical trial
Vimal Stanislaus, Anthony W. Kam, Lily Murphy et al. · BMC Neurology · 2023
Clinical trial · Phase 2Open access · CC BY4 citationsRead the open copy →
- Clinical and dermoscopic changes of acquired melanocytic nevi of patients treated with afamelanotide
Mariachiara Arisi, Mariateresa Rossi, Chiara Rovati et al. · Photochemical & Photobiological Sciences · 2021
Study in humansOpen access · CC BY3 citationsRead the open copy →
- From darkness to light: Case report on afamelanotide-treatment in a 9-year-old child with erythropoietic protoporphyria
Anna‐Elisabeth Minder, Jasmin Barman‐Aksözen · JAAD Case Reports · 2025
Case reportOpen access · CC BY2 citationsRead the open copy →
- Afamelanotide in managing cutaneous phototoxicity in erythropoietic protoporphyria: a Scottish perspective
Robert S Dawe, Alastair C. Kerr, Ewan Eadie et al. · Clinical and Experimental Dermatology · 2025
Open access2 citationsRead the open copy →
- Erythropoietic protoporphyria and afamelanotide: a patient’s perspective
Marese O’Reilly, Victoria A. McGuire, Robert S. Dawe · Clinical and Experimental Dermatology · 2023
Study in humansOpen access2 citationsRead the open copy →
- Afamelanotide improves quality of life and light tolerance in Austrian erythropoietic protoporphyria patients
Magdalena Seidl‐Philipp, Hanna Schratter, Johanna Auer et al. · JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2026
Open access · CC BY-NC1 citationsRead the open copy →
LatestName in title or abstract
- Acute impact of afamelanotide on UVR erythemal and melanogenic responses in healthy humans in vivo: an exploratory study
Liezel L. Griffin, Orsolya Kiss, Poonam Halai et al. · Photochemical & Photobiological Sciences · 2026
Study in humansOpen access · CC BYRead the open copy →
- A Review of Randomized Controlled Trials for Vitiligo Therapies Published Between 2013 and 2023
Natalia Maverakis, Zachary J Jaeger, Delphine J. Lee · Cureus · 2026
ReviewOpen access · CC BYRead the open copy →
- Isopropanol‐Dimethyl Sulfoxide, as a Green Solvent Mixture for Solid‐Phase Peptide Synthesis
Sikabwe Noki, Rajan Sharma, Beatriz G. de la Torre et al. · Chemistry - Methods · 2026
Open access · CC BYRead the open copy →
- Afamelanotide improves quality of life and light tolerance in Austrian erythropoietic protoporphyria patients
Magdalena Seidl‐Philipp, Hanna Schratter, Johanna Auer et al. · JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2026
Open access · CC BY-NC1 citationsRead the open copy →
- New and currently investigated pharmacotherapies for the erythropoietic protoporphyrias: spotlight on dersimelagon and bitopertin
Jasmin Barman‐Aksözen, Francesca Granata, Sebastian Wäscher et al. · Expert Opinion on Pharmacotherapy · 2026
ReviewOpen access · CC BY-NC-NDRead the open copy →
- Adjunctive use of Polypodium leucotomos extract in patients with erythropoietic protoporphyria: An exploratory study
Nayha P. Shetty, Rebecca L. Quiñonez, Marissa S. Ceresnie et al. · Photochemistry and Photobiology · 2026
Clinical trialOpen accessRead the open copy →
- Congenital Erythropoietic Porphyria with Persistent Severe Biochemical Abnormalities and a Non-Mutilating Clinical Course: A Case Report
Supriya Peshin, Kaneez Khan, Ehab Takrori et al. · Reports — Medical Cases Images and Videos · 2026
Case reportOpen access · CC BYRead the open copy →
- An Original PEG‐Functionalized PS Resin Enables Synthesis of Difficult Peptides: Application to Tirzepatide
Ashish Kumar, Peter K. Kabwe, Mahama Alhassan et al. · ChemistrySelect · 2026
Open access · CC BYRead the open copy →
- Keratinocyte–Melanocyte Signaling: Molecular Pathways, Pigmentary Disease, and Therapeutic Targets
Samarth Dhingra · American journal of student research. · 2026
Open accessRead the open copy →
- New pharmacotherapies for the erythropoietic protoporphyrias: an analysis of trial protocols from a patient perspective
Cornelia Dechant, Sebastian Wäscher, Francesca Granata et al. · Orphanet Journal of Rare Diseases · 2025
Study in humansOpen access · CC BY1 citationsRead the open copy →
- From darkness to light: Case report on afamelanotide-treatment in a 9-year-old child with erythropoietic protoporphyria
Anna‐Elisabeth Minder, Jasmin Barman‐Aksözen · JAAD Case Reports · 2025
Case reportOpen access · CC BY2 citationsRead the open copy →
- Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases
Mainak Bardhan, Ayush Anand, Amaan Javed et al. · Diseases · 2025
ReviewOpen access · CC BY5 citationsRead the open copy →
- Melanocortin receptors in GtoPdb v.2025.3
Vanni Caruso, Jeffrey B. Tatro, Helgi B. Schiöth et al. · IUPHAR/BPS Guide to Pharmacology CITE · 2025
Open access · CC BY-SARead the open copy →
- Silica‐Assisted Solid‐Phase Peptide Synthesis (SiPPS)
Nonsikelelo Nkwanyana, Ashish Kumar, Amit Chakraborty et al. · Journal of Peptide Science · 2025
Open access · CC BY-NC-ND4 citationsRead the open copy →
- Afamelanotide in managing cutaneous phototoxicity in erythropoietic protoporphyria: a Scottish perspective
Robert S Dawe, Alastair C. Kerr, Ewan Eadie et al. · Clinical and Experimental Dermatology · 2025
Open access2 citationsRead the open copy →
- A single-centre, prospective, qualitative analysis of knowledge, attitudes and behaviour of sunbed use among patients attending a pigmented lesion clinic in a tertiary referral centre
Fei Ya Lai, Claire Quigley, Gregg Murray et al. · Skin Health and Disease · 2025
Open access · CC BYRead the open copy →
- German Cohort Observational Study to Investigate the Short‐ and Long‐Term Safety and Clinical Effectiveness of Afamelanotide 16 mg ( SCENESSE ) in Patients With Erythropoietic Protoporphyria ( EPP )
Bernhard Homey, Kathrin Schelonke, C Schlegel et al. · Photodermatology Photoimmunology & Photomedicine · 2025
Study in humansOpen access · CC BY-NC-ND7 citationsRead the open copy →
- Treatment advances in Vitiligo: An Updated Review
Ishrat Binti Ismail, Yasmeen Jabeen Bhat, Mohd Shurjeel Ul Islam · Dermatology Practical & Conceptual · 2025
ReviewOpen access · CC BY-NC15 citationsRead the open copy →
- Triethyl phosphate (TEP) – dimethylsulfoxide (DMSO), as a green solvent mixture for solid-phase peptide synthesis (SPPS)
Sikabwe Noki, Luana Lastella, Simona Şerban et al. · Green Chemistry Letters and Reviews · 2024
Open access · CC BY-NC13 citationsRead the open copy →
- 461 The effects of afamelanotide on UVR-induced DNA damage, acute inflammatory and DNA repair responses in human skin
M. Peake, Kirsty J. Rutter, Liezel L. Griffin et al. · Journal of Investigative Dermatology · 2024
Open accessRead the open copy →
- Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for In Vitro Release Testing: Development and Validation
Naresh Mittapelly, Alexandre Djehizian, Krishna Chaitanya Telaprolu et al. · ACS Applied Bio Materials · 2024
Open access · CC BY-NC-ND18 citationsRead the open copy →
- The Impact of Minimal Sunlight Exposure on Bone Health: Insights From a Cohort Study in Erythropoietic Protoporphyria
Louisa G. Kluijver, Margreet A.E.M. Wagenmakers, J.H.P. Wilson et al. · The Journal of Clinical Endocrinology & Metabolism · 2024
Study in humansOpen access · CC BY5 citationsRead the open copy →
- Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs)
Nicholas A. Weirath, Carrie Haskell‐Luevano · ACS Pharmacology & Translational Science · 2024
Open access5 citationsRead the open copy →
- Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management
Anna‐Elisabeth Minder, Louisa G. Kluijver, Jasmin Barman‐Aksözen et al. · Liver International · 2024
ReviewOpen access · CC BY27 citationsRead the open copy →
- Role of microneedling in vitiligo
Aya Haggag, Yomna Mazid El‐Hamd Neinaa, Nagwa M. Elwan · International Journal of Dermatology Venereology and Leprosy Sciences · 2024
Open accessRead the open copy →
- Health Threat in the Tanning Trend
Mohammed Al Abadie · Dermatology and Dermatitis · 2024
Open accessRead the open copy →
- Afamelanotide for Treatment of the Protoporphyrias: Impact on Quality of Life and Laboratory Parameters in a US Cohort
Rebecca Karp Leaf, Hetanshi Naik, Paul Yanning Jiang et al. · Life · 2024
Open access · CC BY6 citationsRead the open copy →
- The effects of cholecalciferol and afamelanotide on vitamin D levels in erythropoietic protoporphyria: a multicentre cohort study
Louisa G. Kluijver, Mitra Nekouei Shahraki, Margreet A.E.M. Wagenmakers et al. · British Journal of Dermatology · 2024
Study in humansOpen access · CC BY4 citationsRead the open copy →
- Toward sustainable solid-phase peptide synthesis strategy – in situ Fmoc removal
Ndumiso Mthethwa, K. P. Nandhini, Ashish Kumar et al. · Green Chemistry Letters and Reviews · 2024
Open access · CC BY18 citationsRead the open copy →
- A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligo
Alireza Jafarzadeh, Arash Pour Mohammad, Mina Khosravi et al. · Skin Research and Technology · 2024
Systematic reviewOpen access · CC BY30 citationsRead the open copy →
- Treatment strategy for erythropoietic protoporphyria accompanied by severe abdominal pain and liver injury
Xiaoxin Wu, Xiumei Zhou, Shuai Zhao et al. · Portal hypertension & cirrhosis · 2024
Open access · CC BY-NC-NDRead the open copy →
Each list shows up to 40 papers.See all 156 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:27 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.