Kisspeptin studies
3,956 journal papers mention Kisspeptin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Kisspeptin is safe, effective or approved for any use.
- Papers
- 3,956
- 3,383 articles, 573 reviews
- Earliest paper
- 1976
- Most papers in 2019 (280)
- Open access
- 61%
- free to read somewhere
- Reviews
- 14%
- of all papers listed
What kind of studies
Of 3,336 papers in PubMed that mention Kisspeptin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials33
- Other clinical trials27
- Meta-analyses and systematic reviews19
- Other reviews768
- Case reports19
- Animal studies only1,674
- Studies in humans1,230
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Kisspeptin in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 36
- Completed
- 23
- Ongoing or planned
- 5
- Phase 1
- 12
- Phase 2
- 8
- Phase 3
- 3
- Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
NCT04648969CompletedPhase 2started 2019-05-03
- Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
NCT07224438RecruitingPhase 2started 2025-12-09
- Kisspeptin Administration Subcutaneously to Patients With IHH
NCT05896293RecruitingPhase 2started 2023-02-03
- Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
NCT07224490RecruitingPhase 1started 2026-03-10
- The Molecular Basis of Inherited Reproductive Disorders
NCT05971836Completedstarted 2021-01-21
The five most recently updated studies. See all 36 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 280 papers in a year. The latest year may still be incomplete.
Where it is published
- Endocrinology330 papers
- Journal of Neuroendocrinology166 papers
- Journal of the Endocrine Society139 papers
- Frontiers in Endocrinology102 papers
- General and Comparative Endocrinology86 papers
The papers
Most citedName in the title
- Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Leonor Pinilla, E. Aguilar, Carlos Diéguez et al. · Physiological Reviews · 2012
ReviewOpen access803 citationsRead the open copy →
- Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
Michael N. Lehman, Lique M. Coolen, Robert L. Goodman · Endocrinology · 2010
ReviewOpen access768 citationsRead the open copy →
- The kisspeptin-GnRH pathway in human reproductive health and disease
Karolina Skorupskaite, Jyothis Thomas George, Richard A. Anderson · Human Reproduction Update · 2014
ReviewOpen access · CC BY503 citationsRead the open copy →
- Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes
Naomi E. Rance, Penny A. Dacks, Melinda Anne Mittelman‐Smith et al. · Frontiers in Neuroendocrinology · 2013
ReviewOpen access380 citationsRead the open copy →
- Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion
Heather M. Dungan Lemko, Donald K. Clifton, Robert A. Steiner · Endocrinology · 2005
Review373 citations
- New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
Juan Roa, E. Aguilar, Carlos Diéguez et al. · Frontiers in Neuroendocrinology · 2007
Review344 citations
LatestName in title or abstract
- Kisspeptin in Assisted Reproduction and Early Pregnancy Failure: Safer Ovulation Triggering and Biomarker-Guided Care—A Narrative Review
Aleksandra Płusa, Damian Broda, Daria Komissarova et al. · Reproductive and Developmental Medicine · 2026
ReviewOpen access · CC BY-NC-NDRead the open copy →
- Early neuroendocrine signatures of polyendocrine metabolic ovarian syndrome risk: Pubertal programming, social brain signals, and novel therapeutic targets
Seda Hanife Oğuz, Bülent Okan Yıldız · Journal of Neuroendocrinology · 2026
ReviewOpen accessRead the open copy →
- The Childhood Estrobolome: A Missing Link in Early Puberty Onset
Md. Zeyaullah, Md Faruque Ahmad · Endocrine Practice · 2026
Review
- Current perspectives on the pharmacologic treatment of boys and adolescents with congenital hypogonadotropic hypogonadism
Rodolfo Alberto Rey, Romina P. Grinspon · Expert Opinion on Pharmacotherapy · 2026
Review
- Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review
V Vasylieva, Annette West, Edward Karpman · Sexual Medicine Reviews · 2026
Review
- Polycystic ovary syndrome: An insight into pathophysiology, current management, and emerging therapeutic approaches
Garima Sahu, Amit K. Goyal · Current Opinion in Pharmacology · 2026
Review
- Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?
Teofana Otilia Bizerea, Flavia Chisavu, Lazar A. Chisavu et al. · International Journal of Molecular Sciences · 2026
ReviewOpen access · CC BYRead the open copy →
Each list shows up to 40 papers.See all 3,956 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:27 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.