Kisspeptin studies
3,956 journal papers mention Kisspeptin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Kisspeptin is safe, effective or approved for any use.
- Papers
- 3,956
- 3,383 articles, 573 reviews
- Earliest paper
- 1976
- Most papers in 2019 (280)
- Open access
- 61%
- free to read somewhere
- Reviews
- 14%
- of all papers listed
What kind of studies
Of 3,336 papers in PubMed that mention Kisspeptin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials33
- Other clinical trials27
- Meta-analyses and systematic reviews19
- Other reviews768
- Case reports19
- Animal studies only1,674
- Studies in humans1,230
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Kisspeptin in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 36
- Completed
- 23
- Ongoing or planned
- 5
- Phase 1
- 12
- Phase 2
- 8
- Phase 3
- 3
- Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
NCT04648969CompletedPhase 2started 2019-05-03
- Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
NCT07224438RecruitingPhase 2started 2025-12-09
- Kisspeptin Administration Subcutaneously to Patients With IHH
NCT05896293RecruitingPhase 2started 2023-02-03
- Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
NCT07224490RecruitingPhase 1started 2026-03-10
- The Molecular Basis of Inherited Reproductive Disorders
NCT05971836Completedstarted 2021-01-21
The five most recently updated studies. See all 36 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1997 to 2026, peak 280 papers in a year. The latest year may still be incomplete.
Where it is published
- Endocrinology330 papers
- Journal of Neuroendocrinology166 papers
- Journal of the Endocrine Society139 papers
- Frontiers in Endocrinology102 papers
- General and Comparative Endocrinology86 papers
The papers
Most citedName in the title
- The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
Masato Kotani, Michel Detheux, Ann L. Vandenbogaerde et al. · Journal of Biological Chemistry · 2001
Study in humansOpen access · CC BY1,548 citationsRead the open copy →
- Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
Sophie Messager, Emmanouella E. Chatzidaki, Dan Ma et al. · Proceedings of the National Academy of Sciences · 2005
Animal studyOpen access1,227 citationsRead the open copy →
- Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Seong‐Kyu Han, Michelle L. Gottsch, Kathy J. Lee et al. · Journal of Neuroscience · 2005
Animal studyOpen access · CC BY-NC-SA1,038 citationsRead the open copy →
- Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons
Jenny Clarkson, Allan Edward Herbison · Endocrinology · 2006
Animal studyOpen access876 citationsRead the open copy →
- Kisspeptin Signaling in the Brain
Amy E. Oakley, Donald K. Clifton, Robert A. Steiner · Endocrine Reviews · 2009
ReviewOpen access845 citationsRead the open copy →
- Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Leonor Pinilla, E. Aguilar, Carlos Diéguez et al. · Physiological Reviews · 2012
ReviewOpen access803 citationsRead the open copy →
- Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse
Victor Manuel Navarro, Michelle L. Gottsch, Charles Chavkin et al. · Journal of Neuroscience · 2009
Animal studyOpen access · CC BY-NC-SA779 citationsRead the open copy →
- Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
Michael N. Lehman, Lique M. Coolen, Robert L. Goodman · Endocrinology · 2010
ReviewOpen access768 citationsRead the open copy →
- Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat
Yoshihiro Wakabayashi, Tomoaki Nakada, Ken Murata et al. · Journal of Neuroscience · 2010
Animal studyOpen access · CC BY-NC-SA598 citationsRead the open copy →
- Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats
Sachika Adachi, Shunji Yamada, Yoshihiro Takatsu et al. · Journal of Reproduction and Development · 2007
Animal studyOpen access · CC BY-NC-ND580 citationsRead the open copy →
- The kisspeptin-GnRH pathway in human reproductive health and disease
Karolina Skorupskaite, Jyothis Thomas George, Richard A. Anderson · Human Reproduction Update · 2014
ReviewOpen access · CC BY503 citationsRead the open copy →
- Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge
Jenny Clarkson, Xavier d’Anglemont de Tassigny, Adriana Santos Moreno et al. · Journal of Neuroscience · 2008
Animal studyOpen access · CC BY-NC-SA500 citationsRead the open copy →
- Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep
Jeremy T. Smith, Lique M. Coolen, Lance J. Kriegsfeld et al. · Endocrinology · 2008
Animal studyOpen access387 citationsRead the open copy →
- Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes
Naomi E. Rance, Penny A. Dacks, Melinda Anne Mittelman‐Smith et al. · Frontiers in Neuroendocrinology · 2013
ReviewOpen access380 citationsRead the open copy →
- Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation
Antonia Kathryn Roseweir, Alexander S. Kauffman, Jeremy T. Smith et al. · Journal of Neuroscience · 2009
Study in humansOpen access · CC BY-NC-SA380 citationsRead the open copy →
- Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol
Justyna Pielecka-Fortuna, Zhiguo Chu, Suzanne M. Moenter · Endocrinology · 2007
Animal studyOpen access345 citationsRead the open copy →
- Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons
Christian Mayer, Maricedes Acosta‐Martínez, Sharon L. Dubois et al. · Proceedings of the National Academy of Sciences · 2010
Animal studyOpen access342 citationsRead the open copy →
- The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep
Guanliang Cheng, Lique M. Coolen, Vasantha Padmanabhan et al. · Endocrinology · 2009
Animal studyOpen access305 citationsRead the open copy →
- Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice
Janette H. Quennell, Christopher S. Howell, Juan Roa et al. · Endocrinology · 2011
Animal studyOpen access291 citationsRead the open copy →
- Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters
Florent G. Revel, Michel Saboureau, Mireille Masson‐Pévet et al. · Current Biology · 2006
Animal studyOpen access290 citationsRead the open copy →
- Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells
Kathryn Backholer, Jeremy T. Smith, A. V. N. Rao et al. · Endocrinology · 2010
Animal studyOpen access289 citationsRead the open copy →
- Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals
Xavier d’Anglemont de Tassigny, Lisa A. Fagg, Mark B. L. Carlton et al. · Endocrinology · 2008
Animal studyOpen access288 citationsRead the open copy →
- Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy
Suresh Ramaswamy, Kathryn A. Guerriero, Robert B. Gibbs et al. · Endocrinology · 2008
Animal studyOpen access281 citationsRead the open copy →
- An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo
Kim L. Keen, Frederick H. Wegner, Stephen Robert Bloom et al. · Endocrinology · 2008
Randomized trialOpen access275 citationsRead the open copy →
LatestName in title or abstract
- Time-Restricted Eating as a Dietary Intervention for Polyendocrine Metabolic Ovarian Syndrome (PMOS): Protocol for a Randomized Controlled Trial
Joanna Maria Pieczyńska-Zając, Sławomira Drzymała-Czyż, Ewa Pruszyńska‐Oszmałek et al. · Nutrients · 2026
Open access · CC BYRead the open copy →
- Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide
Richard Anthony DeFazio, Christian R. Burgess, Laura L. Burger et al. · Journal of Neuroendocrinology · 2026
Animal studyOpen access · CC BYRead the open copy →
- Estrous Cycle-Dependent Expression of Nucleobindin-2/Nesfatin-1 in the Porcine Hypothalamus: Colocalization with GnRH and Kisspeptin
Milena Traut, Ewa Zaobidna, Aleksandra Tkacz et al. · Cells · 2026
Open access · CC BYRead the open copy →
- Progesterone feedback effects on LH pulse and surge secretion in ovariectomized Bos taurus , Bos indicus and crossbred heifers
Sarah M West, Lucas O eSilva, Viviana Garza et al. · Reproduction · 2026
Open access · CC BYRead the open copy →
- ASSOCIATION BETWEEN KISSPEPTIN AND NEUROKININ B WITH MENOPAUSAL SYMPTOMS IN WOMEN AT THE PREMENOPAUSAL STAGE
Ali Kareem Hameed · Jana Nexus Journal of Health and Medicine · 2026
Open access · CC BYRead the open copy →
- Regulation of PACAP gene expression by ovarian sex steroids and kisspeptin: Study using hypothalamic cell lines and an in vivo female rat model
Tuvshintugs Tumurbaatar, Aki Oride, Zhuoma Cairang et al. · Biochemistry and Biophysics Reports · 2026
Open access · CC BYRead the open copy →
- THE INFLUENCE OF KISSPEPTIN-10 ON EXPRESSION OF ANDROGEN AND KISSPEPTIN RECEPTORS IN RAT TESTES AFTER STRESS EXPOSURE
V. Golts, M. Kostina, A. Perova et al. · Problems of Biological Medical and Pharmaceutical Chemistry · 2026
Open accessRead the open copy →
- Kisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis
Qintong Li, Huayu Liu, Yinying He et al. · Cytotechnology · 2026
Open accessRead the open copy →
- Management of Vasomotor Symptoms in Women With Breast Cancer: From Pathophysiology to the Emerging Role of Neurokinin Receptor Antagonism
Kanelina Bimpa, Vasileios Emmanouil, Emmanouil M Xydias et al. · Cureus · 2026
Open access · CC BYRead the open copy →
- First-Trimester Serum Kisspeptin-10 Levels as a Predictor of Spontaneous Abortion: A Prospective Cohort Study
Bilal Efe, Emin Üstünyurt, Tayfur Çift et al. · Journal of Surgery and Medicine · 2026
Open access · CC BY-NC-NDRead the open copy →
- Polyendocrine metabolic ovarian syndrome (PMOS, formerly Polycystic Ovary Syndrome): a systems-biology perspective on neuroendocrine, immuno-metabolic and epigenetic mechanisms across the life course
Yao He, Feng Zhang, Haigang Ding et al. · Journal of Ovarian Research · 2026
Open access · CC BY-NC-NDRead the open copy →
- Hayz sikli buzilgan o‘smir qizlarning gormonal-metabolik profili: klinik-laborator tadqiqot
Рано Наврузова, Shakhodat Ergasheva, Shahodat Ergasheva · Профилактическая медицина и здоровье · 2026
Open access · CC BYRead the open copy →
- Kisspeptin in Assisted Reproduction and Early Pregnancy Failure: Safer Ovulation Triggering and Biomarker-Guided Care—A Narrative Review
Aleksandra Płusa, Damian Broda, Daria Komissarova et al. · Reproductive and Developmental Medicine · 2026
ReviewOpen access · CC BY-NC-NDRead the open copy →
- Induced vs spontaneous ovulation: integrating kisspeptin/neurokinin B/dynorphin circuitry, sensory cues, and ecological context
An An Xie, Aaron J Hsueh · Biology of Reproduction · 2026
Open access · CC BYRead the open copy →
- Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin‐releasing hormone neurons in female mice
J. Rudolph Starrett, Xi Chen, Devon Krasner et al. · Journal of Neuroendocrinology · 2026
Open access · CC BYRead the open copy →
- Early neuroendocrine signatures of polyendocrine metabolic ovarian syndrome risk: Pubertal programming, social brain signals, and novel therapeutic targets
Seda Hanife Oğuz, Bülent Okan Yıldız · Journal of Neuroendocrinology · 2026
ReviewOpen accessRead the open copy →
- 139. Award Talk: Integrative Physiology and Functional Genomics Reveal Novel Mechanisms Regulating Pubertal Development in Gilts.
Clay A Lents, Hiruni R Wijesena, Dan Nonneman et al. · Journal of Animal Science · 2026
Open accessRead the open copy →
- Monosynaptic GABAergic projections from a subset of suprachiasmatic nucleus neuromedin S neurons suppress preoptic area kisspeptin neuron firing in female mice
Wahab Imam Abdulmajeed, Peighton N. Neuman, Bradley B. Jamieson et al. · Journal of Neuroscience · 2026
Open access · CC BY-NC-SARead the open copy →
- 140. Bos Indicus Heifers Have a Reduced Number of Kisspeptin- and Dynorphin-immunopositive Cells in the Arcuate Nucleus Compared to Bos Taurus Heifers.
Sarah M West, Lucas O E Silva, Viviana Garza et al. · Journal of Animal Science · 2026
Open accessRead the open copy →
- Role of the Serum Kisspeptin-1 Level in Early and Late-Onset Preeclampsia
Rawia Muhsin Helal, Shatha A. Kareem Mahmoud · Iraqi postgraduate Medical Journal · 2026
Open accessRead the open copy →
- Paternal kisspeptin-10 treatment ameliorates reproductive and metabolic alterations in the offspring of hypothyroid male rats
Luciano Cardoso Santos, Maria Clara Silva Galrão Cunha, Cleisla Souza Oliveira et al. · Molecular Medicine · 2026
Open access · CC BY-NC-NDRead the open copy →
- Seminal-Plasma Kisspeptin and the Seminal/Serum Kisspeptin Ratio in Relation to Sperm Motility, Morphology and Oxidative Stress in Infertile Iraqi Men
Durar Kamil Jabbar · World Journal of Current Medical and Pharmaceutical Research · 2026
Open access · CC BY-NCRead the open copy →
- Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation
Julie A. Spratt, Neil Tanday, Dearbhla McGinn et al. · Metabolites · 2026
Open access · CC BYRead the open copy →
- Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?
Teofana Otilia Bizerea, Flavia Chisavu, Lazar A. Chisavu et al. · International Journal of Molecular Sciences · 2026
ReviewOpen access · CC BYRead the open copy →
- Neuropeptides in endometriosis-associated pain: a review
G. Polenghi, A. Fiore, Maíra Casalechi et al. · Journal of Endometriosis and Uterine Disorders · 2026
Open access · CC BY-NC-NDRead the open copy →
- Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism
Erikles Macêdo Barbosa, Natália Panhoca Rodrigues, Bianca Reis Santos et al. · Cardiovascular Toxicology · 2026
Animal studyOpen access · CC BYRead the open copy →
- Effects of high-frequency administration of GnRH or kisspeptin on LH pulse and surge profiles in ovariectomized Bos taurus and Bos indicus heifers
Lucas O eSilva, Sarah M West, Viviana Garza et al. · Biology of Reproduction · 2026
Open access · CC BYRead the open copy →
- Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights
Maria A. Netesa, Sarng S. Pyurveev, Андрей Андреевич Лебедев et al. · In Silico Pharmacology · 2026
Open accessRead the open copy →
- Kisspeptin-54 and Phoenixin-14 as Novel Neuroendocrine Biomarkers of Recurrent Miscarriage: Associations with Reproductive and Thyroid Hormones and Diagnostic Performance
Hawraa Hazim, ALAA AL-QAISI, Muataz Adnan Ali · Baghdad Journal of Biochemistry and Applied Biological Sciences · 2026
Open access · CC BYRead the open copy →
Each list shows up to 40 papers.See all 3,956 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:27 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.