Ipamorelin studies
54 journal papers mention Ipamorelin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Ipamorelin is safe, effective or approved for any use.
- Papers
- 54
- 48 articles, 6 reviews
- Earliest paper
- 1998
- Most papers in 1998 (11)
- Open access
- 31%
- free to read somewhere
- Reviews
- 11%
- of all papers listed
What kind of studies
Of 51 papers in PubMed that mention Ipamorelin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials2
- Other clinical trials0
- Meta-analyses and systematic reviews0
- Other reviews10
- Case reports0
- Animal studies only20
- Studies in humans25
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention Ipamorelin in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 3
- Completed
- 2
- Ongoing or planned
- 1
- Phase 1
- 0
- Phase 2
- 2
- Phase 3
- 0
- Trifecta Research Study
NCT07717866Active, not recruitingstarted 2022-08-01
- Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus
NCT00672074CompletedPhase 2started 2008-04
- Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function
NCT01280344CompletedPhase 2started 2011-04
The five most recently updated studies. See all 3 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
1998 to 2026, peak 11 papers in a year. The latest year may still be incomplete.
Where it is published
- Growth Hormone & IGF Research8 papers
- Gastroenterology7 papers
- European Journal of Medicinal Chemistry4 papers
- The American Journal of Sports Medicine2 papers
- The Journal of Sexual Medicine2 papers
The papers
Most citedName in the title
- Ipamorelin, the first selective growth hormone secretagogue
Kirsten Raun, Birgit Sehested Hansen, N. Johansen et al. · European Journal of Endocrinology · 1998
Animal study99 citations
- Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus
Kalina M. Venkova, William Mann, Richard Nelson et al. · Journal of Pharmacology and Experimental Therapeutics · 2009
Animal study34 citations
- A New Series of Highly Potent Growth Hormone-Releasing Peptides Derived from Ipamorelin
Michael Ankersen, Nils Langeland Johansen, Kjeld Madsen et al. · Journal of Medicinal Chemistry · 1998
Animal study33 citations
- The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats
Johan Svensson, Sabrina Lall, Suzanne L. Dickson et al. · Journal of Endocrinology · 2000
Animal studyOpen access29 citationsRead the open copy →
- Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers
Jogarao V. S. Gobburu, Henrik Agersø, William J. Jusko et al. · Pharmaceutical Research · 1999
Randomized trial28 citations
- Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients
On behalf of the Ipamorelin 201 Study Group, David E. Beck, W. Brian Sweeney et al. · International Journal of Colorectal Disease · 2014
Randomized trial · Phase 227 citations
- Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats
Peter B. Johansen, Jette Nowak, Christian Baaner Skjærbæk et al. · Growth Hormone & IGF Research · 1999
Animal study23 citations
- Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals
Bernd Peschke, Michael Ankersen, Birgit Sehested Hansen et al. · European Journal of Medicinal Chemistry · 1999
13 citations
- Highly potent growth hormone secretagogues: Hybrids of NN703 and ipamorelin
Thomas K. Hansen, Michael Ankersen, Kirsten Raun et al. · Bioorganic & Medicinal Chemistry Letters · 2001
Animal study9 citations
- Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus
Beverley Greenwood–Van Meerveld, Karl R. Tyler, Ehsan Mohammadi et al. · Journal of Experimental Pharmacology · 2012
Open access · CC BY-NC6 citationsRead the open copy →
- The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats
N.B. Andersen, Kjell Malmlöf, P.B. Johansen et al. · Growth Hormone & IGF Research · 2001
Animal study6 citations
- The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus
Mallikarjun Gouda, C.B. Ganesh · Animal Reproduction Science · 2024
Animal study4 citations
- Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption
P. B. JOHANSEN · Xenobiotica · 1998
Animal study4 citations
- Ipamorelin — A novel very potent growth hormone secretagogue
MH Rasmussen, B Soogaar, Lars Ynddal et al. · Growth Hormone & IGF Research · 1998
3 citations
- Preclinical Pharmacological Profile of Ipamorelin a Novel Gastroprokinetic for Intestinal Dysmotility
Claudio Pietra, John Friend, Beverley Greenwood–Van Meerveld · Gastroenterology · 2011
2 citations
- The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism
Zengbing Lu, Man Piu Ngan, Julia Y H Liu et al. · Physiology & Behavior · 2024
Animal study1 citations
- Growth hormone secretagogue ipamorelin reduces the hepatic catabolic stress response during steroid treatment
Thorbjørn Grøfte, Casper Skjærbæk, Kjell Malmlöf et al. · Growth Hormone & IGF Research · 1998
1 citations
- Growth hormone secretagogue ipamorelin reduces the hepatic catabolic stress response during steroid treatment
Thorbjørn Grøfte, Casper Skjærbæk, P.B. Johansen et al. · Journal of Hepatology · 1998
1 citations
- Restoring endocrine function in women with premature ovarian insufficiency: A case series on hormonal profile reversal and conception following treatment with Ipamorelin
Joseph Dib MD, Amal Al-Shunnar, Mouna Fawaz et al. · International Journal of Clinical Obstetrics and Gynaecology · 2026
Open accessRead the open copy →
- In Vitro Effect of Ipamorelin, a Novel Ghrelin Agonist on Gastrointestinal Smooth Muscle Isolated From a Rodent Model of Post-Operative Ileus.
Ehsan Mohammadi, Karl R. Tyler, Claudio Pietra et al. · Gastroenterology · 2011
- 716 Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rat Model of Postoperative Ileus
Kalina M. Venkova, William Mann, Richard Nelson et al. · Gastroenterology · 2009
- 14 C‐labelling of ipamorelin, a growth hormone secretagogue
Lars Müller, Kjeld Madsen, Christian Foged · Journal of Labelled Compounds and Radiopharmaceuticals · 1998
- 14C‐labelling of ipamorelin, a growth hormone secretagogue
Lars Müller, Kjeld Madsen, Christian Foged · Journal of Labelled Compounds and Radiopharmaceuticals · 1998
- Effects of ipamorelin — A growth hormone secretagogue-on bone formation and skeletal muscle contraction force
Andersen Nb, Hans Oxlund, Kjell Malmlöf et al. · Growth Hormone & IGF Research · 1998
- Pharmacokinetics of ipamorelin, a new GH secretagogue, after iontophoretic and intravenous administration to volunteers
P Green, Lars Ynddal, Birgitte Søgaard et al. · Growth Hormone & IGF Research · 1998
LatestName in title or abstract
- Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review
V Vasylieva, Annette West, Edward Karpman · Sexual Medicine Reviews · 2026
Review
- The peptide boom: a critical appraisal of evidence, patient safety risks, and regulatory failure in the experimental wellness peptide market
Giorgi Pkhakadze · Georgian Medical Journal · 2026
Open access · CC BYRead the open copy →
- Peptide Supplements and Their Therapeutic Applications in Sports Medicine
Kushagra Tewari, Timothy P. Liu, Christina Im et al. · The American Journal of Sports Medicine · 2026
Open access · CC BY1 citationsRead the open copy →
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration
Aleksander Dominikowski, Zofia Rękoś, Michał Olejarz et al. · Frontiers in Endocrinology · 2026
ReviewOpen access · CC BY1 citationsRead the open copy →
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Volodymyr Mavrych, Inna Shypilova, Olena Bolgova · Frontiers in Aging · 2026
ReviewOpen access · CC BY5 citationsRead the open copy →
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Omar F. Rahman, Steven J. Lee, William A. Seeds · JAAOS Global Research and Reviews · 2026
ReviewOpen access · CC BY-NC-ND5 citationsRead the open copy →
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Cory K. Mayfield, Ioanna K. Bolia, Cailan L Feingold et al. · The American Journal of Sports Medicine · 2026
Review12 citations
- Restoring endocrine function in women with premature ovarian insufficiency: A case series on hormonal profile reversal and conception following treatment with Ipamorelin
Joseph Dib MD, Amal Al-Shunnar, Mouna Fawaz et al. · International Journal of Clinical Obstetrics and Gynaecology · 2026
Open accessRead the open copy →
- Growth Hormone Secretagogues: Between Endocrine Physiology and the Therapeutic Frontier of GH-IGF-1 Axis-Modulating Peptides
Pedro Augusto Zaiats, Pedro Henrique Rodrigues Senteio, Diego Ribeiro et al. · Open Journal of Clinical Diagnostics · 2026
Open access · CC BYRead the open copy →
- (197) Peptides in Practice: Evaluating Efficacy and Safety in Men’s Health
R Arora, Arjun K. Venkatesh, Gene Austin Krishingner et al. · The Journal of Sexual Medicine · 2025
Open accessRead the open copy →
- (349) Therapeutic Peptides in Sexual Medicine: A Narrative Review
E Burchfiel, N Mills, G Saffati et al. · The Journal of Sexual Medicine · 2025
ReviewOpen accessRead the open copy →
- The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism
Zengbing Lu, Man Piu Ngan, Julia Y H Liu et al. · Physiology & Behavior · 2024
Animal study1 citations
- The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus
Mallikarjun Gouda, C.B. Ganesh · Animal Reproduction Science · 2024
Animal study4 citations
- Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics
Ehsan Mohammadi, Tijs Louwies, Claudio Pietra et al. · Journal of Experimental Pharmacology · 2020
Open access · CC BY-NC3 citationsRead the open copy →
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males
Deepankar K. Sinha, Adithya Balasubramanian, Alexander J. Tatem et al. · Translational Andrology and Urology · 2020
ReviewOpen access · CC BY-NC-ND11 citationsRead the open copy →
- A stable meta‐carborane enables the generation of boron‐rich peptide agonists targeting the ghrelin receptor
Dennis J. Worm, Sylvia Els‐Heindl, Martin Kellert et al. · Journal of Peptide Science · 2018
Study in humans45 citations
- Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor
Milan M. Fowkes, Tyler J. Lalonde, Lihai Yu et al. · European Journal of Medicinal Chemistry · 2018
Study in humans11 citations
- Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients
On behalf of the Ipamorelin 201 Study Group, David E. Beck, W. Brian Sweeney et al. · International Journal of Colorectal Disease · 2014
Randomized trial · Phase 227 citations
- Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus
Beverley Greenwood–Van Meerveld, Karl R. Tyler, Ehsan Mohammadi et al. · Journal of Experimental Pharmacology · 2012
Open access · CC BY-NC6 citationsRead the open copy →
- Does the Prevalence of Fructose and Lactose Intolerance Differ Between ROME III Subgroups of Functional Dyspepsia (FD) and Irritable Bowel Syndrome (IBS)?
Clive H. Wilder‐Smith, Andrea Materna · Gastroenterology · 2011
Open accessRead the open copy →
- ROME III Functional Dyspepsia (FD) Criteria: Poor Discrimination Between Postprandial Distress Syndrome (PDS) and Epigastric Pain Syndrome (EPS)
Nimish B. Vakil, Katarina Halling, Börje Wernersson et al. · Gastroenterology · 2011
Open access2 citationsRead the open copy →
- Preclinical Pharmacological Profile of Ipamorelin a Novel Gastroprokinetic for Intestinal Dysmotility
Claudio Pietra, John Friend, Beverley Greenwood–Van Meerveld · Gastroenterology · 2011
2 citations
- Regional Analysis of Gastric Emptying Scintigraphy Provides Better Correlation of Dyspeptic Symptoms With Abnormal Gastric Emptying
Murali Pathikonda, Steven Kantor, Robert S. Fisher et al. · Gastroenterology · 2011
3 citations
- In Vitro Effect of Ipamorelin, a Novel Ghrelin Agonist on Gastrointestinal Smooth Muscle Isolated From a Rodent Model of Post-Operative Ileus.
Ehsan Mohammadi, Karl R. Tyler, Claudio Pietra et al. · Gastroenterology · 2011
- Enteric Dysmotility/ Acquired Chronic Intestinal Pseudo-Obstruction (ED/CIPO) – Relationship Between Small Intestinal Manometric and Neurohistopathological Findings
Dilshad Chowdhury, Ana H. Raimundo, Ara Wardkes Darzi et al. · Gastroenterology · 2011
- 716 Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rat Model of Postoperative Ileus
Kalina M. Venkova, William Mann, Richard Nelson et al. · Gastroenterology · 2009
- Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus
Kalina M. Venkova, William Mann, Richard Nelson et al. · Journal of Pharmacology and Experimental Therapeutics · 2009
Animal study34 citations
- Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats
Niels Kristian Aagaard, Thorbjørn Grøfte, Jacob Raben Greisen et al. · Growth Hormone & IGF Research · 2009
Animal study4 citations
- Seabream ghrelin: cDNA cloning, genomic organization and promoter studies
Chung-Man Yeung, Chi Bun Chan, Norman Y.S. Woo et al. · Journal of Endocrinology · 2006
Animal studyOpen access55 citationsRead the open copy →
- Stimulation of growth hormone secretion from seabream pituitary cells in primary culture by growth hormone secretagogues is independent of growth hormone transcription
Chi Bun Chan, C.K. Fung, Wendy Fung et al. · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · 2004
Study in humans16 citations
- Growth Hormone (GH) Hypersecretion and GH Receptor Resistance in Streptozotocin Diabetic Mice in Response to a GH Secretagogue
Peter B. Johansen, Yael Segev, Daniel Landau et al. · Journal of Diabetes Research · 2003
Study in humansOpen access · CC BY10 citationsRead the open copy →
- The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency
Bernd Peschke, Michael Ankersen, Michael W Bauer et al. · European Journal of Medicinal Chemistry · 2002
Animal study9 citations
- The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats
N.B. Andersen, Kjell Malmlöf, P.B. Johansen et al. · Growth Hormone & IGF Research · 2001
Animal study6 citations
- Highly potent growth hormone secretagogues: Hybrids of NN703 and ipamorelin
Thomas K. Hansen, Michael Ankersen, Kirsten Raun et al. · Bioorganic & Medicinal Chemistry Letters · 2001
Animal study9 citations
- Do Growth Hormone–Releasing Peptides Act as Ghrelin Secretagogues?
Ian Ahnfelt-Rønne, Jette Nowak, Uffe Bang Olsen · Endocrine · 2001
Animal study11 citations
- Growth Hormone (GH)-Independent Stimulation of Adiposity by GH Secretagogues
Sabrina Lall, Loraine Y.C. Tung, Claes Ohlsson et al. · Biochemical and Biophysical Research Communications · 2001
Animal study88 citations
- The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats
Johan Svensson, Sabrina Lall, Suzanne L. Dickson et al. · Journal of Endocrinology · 2000
Animal studyOpen access29 citationsRead the open copy →
- Methylprednisolone does not inhibit the release of growth hormone after intravenous injection of a novel growth hormone secretagogue in rats
Kjell Malmlöf, P.B. Johansen, P-M Haahr et al. · Growth Hormone & IGF Research · 1999
Animal study8 citations
- Demonstration of the strength of focused combinatorial libraries in SAR optimisation of growth hormone secretagogues
Michael Ankersen · European Journal of Medicinal Chemistry · 1999
11 citations
- Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers
Jogarao V. S. Gobburu, Henrik Agersø, William J. Jusko et al. · Pharmaceutical Research · 1999
Randomized trial28 citations
Each list shows up to 40 papers.See all 54 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.