GHRP-6 studies
676 journal papers mention GHRP-6 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether GHRP-6 is safe, effective or approved for any use.
- Papers
- 676
- 666 articles, 10 reviews
- Earliest paper
- 1988
- Most papers in 2011 (32)
- Open access
- 31%
- free to read somewhere
- Reviews
- 1%
- of all papers listed
What kind of studies
Of 639 papers in PubMed that mention GHRP-6 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials19
- Other clinical trials23
- Meta-analyses and systematic reviews0
- Other reviews28
- Case reports5
- Animal studies only351
- Studies in humans234
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
1997 to 2026, peak 32 papers in a year. The latest year may still be incomplete.
Where it is published
- Peptides34 papers
- Endocrinology28 papers
- Clinical Endocrinology22 papers
- The Journal of Clinical Endocrinology & Metabolism22 papers
- Journal of Endocrinology21 papers
The papers
Most citedName in the title
- Regulation of PIT-1 Expression By Ghrelin and GHRP-6 Through the GH Secretagogue Receptor
Ángel Galindo García, Clara V. Álvarez, Roy G. Smith et al. · Molecular Endocrinology · 2001
Study in humansOpen access96 citationsRead the open copy →
- The Effects of Ghrelin Antagonists [ D ‐ L ys3]‐ GHRP ‐6 or JMV 2959 on Ethanol, Water, and Food Intake in C57BL/6J Mice
Juan L. Gomez, Andrey E. Ryabinin · Alcoholism Clinical and Experimental Research · 2014
Animal studyOpen access76 citationsRead the open copy →
- Gastric mucosal damage in water immersion stress: Mechanism and prevention with GHRP-6
Shu Guo · World Journal of Gastroenterology · 2012
Animal studyOpen access · CC BY-NC57 citationsRead the open copy →
- Effect of obesity and morbid obesity on the growth hormone (GH) secretion elicited by the combined GHRH + GHRP‐6 test
Fahrettin Keleştimur, Vera M. POPOVIC, Alfonso Leal et al. · Clinical Endocrinology · 2006
Study in humansOpen access45 citationsRead the open copy →
- The Peptidic GHS-R antagonist [D-Lys3]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity
Lenka Maletı́nská, Resha Matyšková, Jana Maixnerová et al. · Molecular and Cellular Endocrinology · 2011
Study in humansOpen access44 citationsRead the open copy →
- Identification of Ghrelin Receptor Blocker, D-[Lys3] GHRP-6 as a CXCR4 Receptor Antagonist
Kalpesh G. Patel, Vishwa Deep Dixit, Jun Ho Lee et al. · International Journal of Biological Sciences · 2012
Study in humansOpen access · CC BY-NC40 citationsRead the open copy →
- Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning
Kazuo Katoh, G Furukawa, K Kitade et al. · Journal of Endocrinology · 2004
Animal studyOpen access27 citationsRead the open copy →
- The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist
Kalpesh G. Patel, Vishwa Deep Dixit, Jun Ho Lee et al. · International Journal of Medical Sciences · 2012
Study in humansOpen access · CC BY-NC24 citationsRead the open copy →
- Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure
Danay Cibrián, Hussam Ajamieh, Jorge Berlanga et al. · Clinical Science · 2006
Study in humansOpen access · CC BY23 citationsRead the open copy →
- Hypothalamic expression of NPY mRNA, vasopressin mRNA and CRF mRNA in response to food restriction and central administration of the orexigenic peptide GHRP-6
Louise E. Johnstone, Rungrudee Srisawat, Ekkasit Kumarnsit et al. · Stress · 2005
Animal studyOpen access22 citationsRead the open copy →
LatestName in title or abstract
- Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts
Wanru Feng, Xinlei Fu, Ningning Hu et al. · Tissue and Cell · 2026
Open access · CC BY-NC-NDRead the open copy →
- Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report
Sui-Ling Perez, Lynette Martinez, Michael Rosselli et al. · Frontiers in Surgery · 2026
Case reportOpen access · CC BYRead the open copy →
- Redefining post-stress depression as a spatiotemporal five-disease multimorbidity trajectory: ghrelin-driven anchoring by Shugan absorbed compounds
Xi Huang, Runze Zhou, Chendong Xu et al. · Exploration of Neuroprotective Therapy · 2026
Open access · CC BYRead the open copy →
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration
Aleksander Dominikowski, Zofia Rękoś, Michał Olejarz et al. · Frontiers in Endocrinology · 2026
ReviewOpen access · CC BY1 citationsRead the open copy →
- The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling
Lingling Zhang, Jiani Yuan, Ningning Hu et al. · Biomolecules · 2026
Study in humansOpen access · CC BYRead the open copy →
- Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation
Linlin Wang, Arielis Rodríguez‐Ulloa, Jorge Berlanga‐Acosta et al. · Pharmaceuticals · 2026
Open access · CC BYRead the open copy →
- Modulatory Role of Oral GHRP-6 in the Immune Response and Digestive Enzyme Function in Juvenile Tilapia (Oreochromis sp.) Challenged with Pseudomonas aeruginosa
Liz Mariam de Armas, Adrian Rodriguez-Gabilondo, Liz Hernández et al. · Fishes · 2026
Open access · CC BYRead the open copy →
- Growth Hormone Secretagogues: Between Endocrine Physiology and the Therapeutic Frontier of GH-IGF-1 Axis-Modulating Peptides
Pedro Augusto Zaiats, Pedro Henrique Rodrigues Senteio, Diego Ribeiro et al. · Open Journal of Clinical Diagnostics · 2026
Open access · CC BYRead the open copy →
- Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation
Xiaotong Zhao, Kai Pan, Rui Li et al. · Journal of Nanobiotechnology · 2025
Study in humansOpen access · CC BY-NC-ND2 citationsRead the open copy →
- Chronic ghrelin administration suppresses IKK/NF‐κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ‐diabetic rats
Louyan Ma, Qiumin Qu · Alzheimer s & Dementia · 2025
Open access · CC BYRead the open copy →
- The ghrelin receptor agonist AC01 improves cardiomyocyte contractility through Gαi signalling and without Ca2+ mobilization
Lars H. Lund, Camilla Hage, Mattias Carlström et al. · Cardiovascular Research · 2025
Open access · CC BY4 citationsRead the open copy →
- Aza-Isotryptophan: Synthesis, Pictet–Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor
Xiaozheng Wei, Mukandila Mulumba, Sylvain Chemtob et al. · Journal of Medicinal Chemistry · 2025
Study in humansOpen access · CC BY-NC-NDRead the open copy →
- Therapeutic Potential of SH-HP (His-D-Trp-Ala-Trp-D-Phe-Lys) in Helicobacter Pylori Infection and Acute Gastric Intoxication
Mohammed Mahdi Salman Ghadban · .مجلة النسور للعلوم الطبية · 2025
Open accessRead the open copy →
- The Ghrelin Analog GHRP-6, Delivered Through Aquafeeds, Modulates the Endocrine and Immune Responses of Sparus aurata Following IFA Treatment
Leandro Rodríguez-Viera, Anyell Caderno, Rebeca Martı́nez et al. · Biology · 2025
Open access · CC BY3 citationsRead the open copy →
- Ghrelin as a Promising Immunostimulant in Aquaculture: Mechanisms and Therapeutic Potential
D. M. Reyes, Mario Pablo Estrada, Rebeca Martı́nez · Bionatura journal : · 2025
Open access · CC BYRead the open copy →
- Ghrelin as a Promising Immunostimulant in Aquaculture: Mechanisms and Therapeutic Potential
D. M. Reyes, Mario Pablo Estrada, Rebeca Martı́nez · Bionatura journal : · 2025
Open access · CC BY1 citationsRead the open copy →
- Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study
zhong mengyu, Jian Zhu, Bohan Zhang et al. · Metabolic Brain Disease · 2025
Study in humansOpen access · CC BYRead the open copy →
- A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade
Nadia Olivier, Brian Herbert Harvey, Stanislav Gobec et al. · Biomedicine & Pharmacotherapy · 2025
Animal studyOpen access · CC BY7 citationsRead the open copy →
- Anti-nervous necrosis virus activity of the growth hormone releasing peptide-6, GHRP-6
Daniel Álvarez‐Torres, Rebeca Martı́nez, Patricia Moreno et al. · Aquaculture International · 2025
Open access · CC BY1 citationsRead the open copy →
- Danshen-Chuanxiong-Honghua ameliorates neurological function and inflammation in traumatic brain injury in rats via modulating Ghrelin/GHSR
Xiaohang Zhang, Yawen Cai, Meng Chen et al. · Journal of Ethnopharmacology · 2025
Animal studyOpen access9 citationsRead the open copy →
- GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival
Jiang Zhu, Tanfang Zhou, Guangfeng Chen et al. · Veterinary Research · 2025
Animal studyOpen access · CC BY6 citationsRead the open copy →
- Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke
Carolin Beuker, Ulrike Schreiner, Jan‐Kolja Strecker et al. · Neurological Research and Practice · 2025
Open access · CC BY5 citationsRead the open copy →
- Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice
Renée Poelman, Marie V. Le May, Erik Schéle et al. · Endocrinology · 2025
Animal studyOpen access · CC BY3 citationsRead the open copy →
- Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats
Jázmin Ayman, András Búzás, Roberta Dochnal et al. · Biomedicines · 2025
Open access · CC BYRead the open copy →
- Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis
Jiang Zhu, Hongqiong Zhao, Aili Aierken et al. · PLoS neglected tropical diseases · 2024
Study in humansOpen access · CC BY10 citationsRead the open copy →
- Ghrelin Modulates Voltage-Gated Ca2+ Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons
Hannah J. Goudsward, Víctor Ruiz-Velasco, S Stella et al. · Molecular Pharmacology · 2024
Animal studyOpen access4 citationsRead the open copy →
- Discussion about the Role of Ghrelin in Myocardial Ischemia/Reperfusion and its Possible Mechanism
Gang Huang, Nan Zheng, Yinqing Huang · Pharmacognosy Magazine · 2024
Open access · CC BY-NC2 citationsRead the open copy →
- Ghrelin is essential for lowering blood pressure during torpor
Kazuma Matsui, Takanori Ida, Kanae Oishi et al. · Frontiers in Endocrinology · 2024
Animal studyOpen access · CC BY2 citationsRead the open copy →
- The ghrelin receptor agonist AC01 improves cardiac function in non-human primates and in mice with heart failure by increasing cardiomyocyte contractility
Gianluigi Pironti, Camilla Hage, Mattias Carlström et al. · European Heart Journal · 2024
Open accessRead the open copy →
- Rikkunshito improves anorexia through ghrelin‐ and orexin‐dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats
Koji Yakabi, Naomi Yamaguchi, Kiyoshige Takayama et al. · Neurogastroenterology & Motility · 2024
Animal studyOpen access · CC BY4 citationsRead the open copy →
Each list shows up to 40 papers.See all 676 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.