Semax studies
179 journal papers mention Semax in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Semax is safe, effective or approved for any use.
- Papers
- 179
- 179 articles, 0 reviews
- Earliest paper
- 1991
- Most papers in 2006 (13)
- Open access
- 19%
- free to read somewhere
- Reviews
- 0%
- of all papers listed
What kind of studies
Of 210 papers in PubMed that mention Semax in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials1
- Other clinical trials3
- Meta-analyses and systematic reviews0
- Other reviews11
- Case reports0
- Animal studies only145
- Studies in humans49
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
1996 to 2025, peak 13 papers in a year. The latest year may still be incomplete.
Where it is published
- Bulletin of Experimental Biology and Medicine35 papers
- European Neuropsychopharmacology22 papers
- Doklady Biological Sciences17 papers
- Neurochemical Journal9 papers
- Biology Bulletin6 papers
The papers
Most citedName in the title
- Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Oleg V. Dolotov, Ekaterina A. Karpenko, Ludmila S. Inozemtseva et al. · Brain Research · 2006
Animal study57 citations
- Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia
Veronika G. Dmitrieva, О. В. Поварова, Veronika Igorevna Skvortsova et al. · Cellular and Molecular Neurobiology · 2009
Animal studyOpen access54 citationsRead the open copy →
- Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog
Maria I. Shadrina, Oleg V. Dolotov, Igor A. Grivennikov et al. · Neuroscience Letters · 2001
Animal study46 citations
- Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity
Tatyana P. Storozhevykh, Г. Р. Тухбатова, Ya. E. Senilova et al. · Bulletin of Experimental Biology and Medicine · 2007
Animal study41 citations
- Novel synthetic analogue of ACTH 4–10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia
Valentina G. Bashkatova, В. Б. Кошелев, Olga E. Fadyukova et al. · Brain Research · 2001
Animal study36 citations
- The Effect of Semax and Its C-End Peptide PGP on the Morphology and Proliferative Activity of Rat Brain Cells During Experimental Ischemia: A Pilot Study
Vasily V. Stavchansky, Vadim V. Yuzhakov, A. Yu. Botsina et al. · Journal of Molecular Neuroscience · 2010
Study in humans34 citations
- Synthetic ACTH analogue Semax displays nootropic‐like activity in humans
Alexander Kaplan, A. G. Kochetova, V.N. Nezavibathko et al. · Neuroscience Research Communications · 1996
34 citations
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
Ekaterina V. Medvedeva, Veronika G. Dmitrieva, О. В. Поварова et al. · BMC Genomics · 2014
Animal studyOpen access · CC BY33 citationsRead the open copy →
- Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats
Ivan B. Filippenkov, Vasily V. Stavchansky, Alina E. Denisova et al. · Genes · 2020
Study in humansOpen access · CC BY29 citationsRead the open copy →
- Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents
К. О. Еремин, В. С. Кудрин, Pirjo Saransaari et al. · Neurochemical Research · 2005
Animal study29 citations
- Semax as a Universal Drug for Therapy and Research
Svetlana Viktorovna Koroleva, Nikolai F. Myasoedov · Biology Bulletin · 2018
27 citations
- Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain‐derived neurotrophic factor protein in rat basal forebrain
Oleg V. Dolotov, Ekaterina A. Karpenko, Tamara S. Seredenina et al. · Journal of Neurochemistry · 2006
Animal study25 citations
- The efficacy of semax in the tretament of patients at different stages of ischemic stroke
Eugene I. Gusev, M. Yu. Martynov, Elena V. Kostenko et al. · S S Korsakov Journal of Neurology and Psychiatry · 2018
Clinical trial24 citations
- Semax, an analog of ACTH(4−7), regulates expression of immune response genes during ischemic brain injury in rats
Ekaterina V. Medvedeva, Veronika G. Dmitrieva, Svetlana A. Limborska et al. · Molecular Genetics and Genomics · 2017
Animal study23 citations
- Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action
Natalia G. Levitskaya, Dmitry A. Vilensky, Elena A. Sebentsova et al. · Biology Bulletin · 2010
Animal study21 citations
- Comparison of the Temporary Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina Under Semax Action
Maria I. Shadrina, Timur A. Kolomin, Tamara M. Agapova et al. · Journal of Molecular Neuroscience · 2009
Study in humans20 citations
- The Heptapeptide SEMAX stimulates BDNF Expression in Different Areas of the Rat Brain in vivo
Oleg V. Dolotov, Tamara S. Seredenina, Natalia G. Levitskaya et al. · Doklady Biological Sciences · 2003
Animal study19 citations
- Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity
Giovanni Tabbı̀, Antonio L. Magrì, Alessandro Giuffrida et al. · Journal of Inorganic Biochemistry · 2014
18 citations
- Effect of Semax and its C-terminal Fragment Pro-Gly-Pro on the Expression of VEGF Family Genes and their Receptors in Experimental Focal Ischemia of the Rat Brain
Ekaterina V. Medvedeva, Veronika G. Dmitrieva, О. В. Поварова et al. · Journal of Molecular Neuroscience · 2012
Animal study18 citations
- Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH4–10
T. Yu. Agapova, Ya. V. Agniullin, Maria I. Shadrina et al. · Neuroscience Letters · 2007
Animal study18 citations
- Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
Michele F. M. Sciacca, Налетова Ирина Николаевна, Maria Laura Giuffrida et al. · ACS Chemical Neuroscience · 2022
Study in humansOpen access · CC BY17 citationsRead the open copy →
- Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress
М. А. Самотруева, Anna L. Yasenyavskaya, V.Kh. Murtalieva et al. · Bulletin of Experimental Biology and Medicine · 2019
Animal study17 citations
- Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex
G. A. Romanova, Denis N. Silachev, F. M. Shakova et al. · Bulletin of Experimental Biology and Medicine · 2006
Animal study17 citations
- The Binding of Semax, ACTH 4–10 Heptapeptide, to Plasma Membranes of the Rat Forebrain Basal Nuclei and Its Biodegradation
Oleg V. Dolotov, Yu. A. Zolotarev, E. M. Dorokhova et al. · Russian Journal of Bioorganic Chemistry · 2004
Animal study17 citations
- The effect of semax and the C-terminal peptide PGP on expression of growth factor genes and receptors in rats under conditions of experimental cerebral ischemia
Veronika G. Dmitrieva, Lyudmila V. Dergunova, О. В. Поварова et al. · Doklady Biochemistry and Biophysics · 2008
Animal study16 citations
- Kinetics of semax penetration into the brain and blood of rats after its intranasal administration
Konstantin V. Shevchenko, Igor Yu Nagaev, L. Yu. Alfeeva et al. · Russian Journal of Bioorganic Chemistry · 2006
Animal study16 citations
- Degradation of ACTH/MSH(4–10) and its synthetic analog semax by rat serum enzymes: An inhibitor study
Vladimir N. Potaman, L. Yu. Alfeeva, Andrey A. Kamensky et al. · Peptides · 1993
Animal study16 citations
- N-terminal degradation of ACTH(4–10) and its synthetic analog semax by the rat blood enzymes
Vladimir N. Potaman, L. Yu. Alfeeva, Andrey A. Kamensky et al. · Biochemical and Biophysical Research Communications · 1991
Animal study16 citations
- Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion
Olga Yu. Sudarkina, Ivan B. Filippenkov, Vasily V. Stavchansky et al. · International Journal of Molecular Sciences · 2021
Animal studyOpen access · CC BY15 citationsRead the open copy →
- Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes
Yu. A. Zolotarev, Oleg V. Dolotov, Ludmila S. Inozemtseva et al. · Amino Acids · 2006
Animal study15 citations
- Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats
Ksenia A. Yatsenko, Nataliya Yu. Glazova, Ludmila S. Inozemtseva et al. · Doklady Biological Sciences · 2013
Animal study14 citations
- Investigation of neuroprotective action of drug “Semax” at ischemic insult by Raman spectroscopy method by estimation of damage of low density lipoprotein of rat blood
Irina M. Vlasova, Alexander M. Saletsky · Laser Physics · 2009
14 citations
- Effects of behaviorally active ACTH (4–10) analogue – Semax on rat basal forebrain cholinergic neurons
Igor A. Grivennikov, Oleg V. Dolotov, Yu. A. Zolotarev et al. · Restorative Neurology and Neuroscience · 2008
Animal study14 citations
- Effect of Semax Peptide on Survival of Cultured Rat Pheochromocytoma Cells during Oxidative Stress
E. R. Safarova, Stanislav Ivanovich Shram, Yu. A. Zolotarev et al. · Bulletin of Experimental Biology and Medicine · 2003
Animal study14 citations
- Effect of semax and its C-terminal peptide PGP on expression of neurotrophins and their receptors in rat brain during incomplete global ischemia
Vasily V. Stavchansky, Творогова Татьяна Васильевна, A. Yu. Botsina et al. · Molecular Biology · 2011
13 citations
- Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential for their practical application
L. A. Lyapina, V. E. Pastorova, T. Yu. Obergan et al. · Biology Bulletin · 2006
Review13 citations
- The Neuroprotective Effects of Semax in Conditions of MPTP-Induced Lesions of the Brain Dopaminergic System
Natalia G. Levitskaya, Elena A. Sebentsova, Л. А. Андреева et al. · Neuroscience and Behavioral Physiology · 2004
Animal study11 citations
- Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum
Н. В. Кост, Oleg Yu. Sokolov, Marina V. Gabaeva et al. · Russian Journal of Bioorganic Chemistry · 2001
Study in humans11 citations
- Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress
Maria V. Svishcheva, Александра Юрьевна Мухина, О. А. Медведева et al. · Bulletin of Experimental Biology and Medicine · 2020
Animal study10 citations
- Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome
Shih‐Jen Tsai · Medical Hypotheses · 2006
Study in humans10 citations
LatestName in title or abstract
- The potential of the peptide drug Semax and Its derivative for correcting pathological impairments in the animal model of Alzheimer’s disease
Alexandra I. Radchenko, Elеna V. Kuzubova, Alina Apostol et al. · Acta Naturae · 2025
Open access · CC BY2 citationsRead the open copy →
- The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons
Sergey N. Kolbaev, Irina N. Sharonova, Vladimir G. Skrebitsky · Bulletin of Experimental Biology and Medicine · 2025
Animal study
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
Rongjie Liu, Yituo Chen, Haosheng Huang et al. · British Journal of Pharmacology · 2025
Animal study4 citations
- Study of the effectiveness of the drug «Semax» in the complex treatment of non-proliferative diabetic retinopathy
D. M. Tuychibaeva, Urmanova Firuza Makhkamovna · Modern technologies in ophtalmology · 2025
- The effect of peptide Semax, an ACTH(4-10) analogue on intracellular calcium dynamics in rat brain neurons
Sergey N. Kolbaev, Irina N. Sharonova, Vladimir G. Skrebitsky · Bulletin of Experimental Biology and Medicine · 2025
- Semax, a Copper Chelator Peptide, Decreases the Cu(II)‐Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing
Marianna Flora Tomasello, Maria Carmela Di Rosa, Налетова Ирина Николаевна et al. · Bioinorganic Chemistry and Applications · 2025
Open access · CC BY4 citationsRead the open copy →
- THE ADAPTOGENIC EFFECT OF SEMAX IN WISTAR RATS DURING SHORT-TERM PHYSICAL EXERTION
Коробова Виктория Николаевна, Ворвуль Антон Олегович, Игорь Иванович Бобынцев et al. · Avicenna Bulletin · 2025
Open access · CC BYRead the open copy →
- Motor activity and neurological deficit restoration as the result of combined semax and hopantenic acid influence in experimental chronic brain ischemia
V. V. Kirchev · Journal of Education Health and Sport · 2024
Open access · CC BY-NC-SARead the open copy →
- Semax intranasal improve memory deficiency in conditions of experimental chronic brain ischemia
V. V. Kirchev · Journal of Education Health and Sport · 2024
Open access · CC BY-NC-SARead the open copy →
- Antidepressant-like and antistress effects of the ACTH(4–10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress
Ludmila S. Inozemtseva, Ksenia A. Yatsenko, Н. Ю. Глазова et al. · European Journal of Pharmacology · 2024
Animal study4 citations
- Role of Semax and Selank neuropeptides in modulating cell-mediated immunity in the setting of skin burn injury
Альфия Кадыровна Ажикова, М. А. Самотруева, Л. А. Андреева et al. · RUDN Journal of Medicine · 2024
Open access · CC BY-NCRead the open copy →
- Study of the role of neurotrophic factors in the regulation of regeneration processes in damaged somatic nerves under the action of semax peptide preparation
Marina Vladimirovna Parchaykina, Tatyana P. Kuzmenko, Elena V. Chudaikina et al. · Izvestiya of Saratov University Chemistry Biology Ecology · 2023
Open access · CC BYRead the open copy →
- Semax as a modulator of the psycho-emotional status of rats in an experimental model of depression based on stress
Вероника Хамидуллаевна Мурталиева, Anna L. Yasenyavskaya, Л. А. Андреева et al. · Сибирский научный медицинский журнал · 2023
Open access · CC BY1 citationsRead the open copy →
- Phenibut, Semax, and GIZh-290 Modulate Cortical mGluII Receptors in an Attention Deficit Model in Mice
N. A. Sukhorukova, Екатерина Валерьевна Васильева, Georgy I. Kovalev · Neurochemical Journal · 2023
2 citations
- Common and Specific Effects of Selank, Noopept, and Semax on the Glycine Site of the NMDA Receptor in BALB/c and C57Bl/6 Mice Brains
Екатерина Валерьевна Васильева, Алия Анвяровна Абдуллина, Georgy I. Kovalev · Neurochemical Journal · 2023
- Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration
V. V. Kirchev · Journal of Education Health and Sport · 2023
Open access · CC BY-NC-SA1 citationsRead the open copy →
- Phenibut, Semax and GIZh-290 Modulate Cortical mGluII Receptors in an Attention Deficit Model in Mice
N. A. Sukhorukova, Екатерина Валерьевна Васильева, Georgy I. Kovalev · Нейрохимия · 2023
- Common and Specific Effects of Selank, Noopept, and Semax to Glycine Site of the NMDA Receptor in BALB/c and C57Bl/6 Mice Brain
Georgy I. Kovalev, Екатерина Валерьевна Васильева, Алия Анвяровна Абдуллина · Нейрохимия · 2023
Open accessRead the open copy →
- Effects of Semax in the Rat Models of Acute Stress
Nataliya Yu. Glazova, Д. М. Манченко, Dmitry A. Vilensky et al. · Journal of Evolutionary Biochemistry and Physiology · 2023
- Effects of Semax in the Models of Acute Stress
Nataliya Yu. Glazova, Nikolai F. Myasoedov, S. A. Limborska et al. · Российский физиологический журнал им И М Сеченова · 2023
Open accessRead the open copy →
- Influence of Semax on the Level of Pro- and Anti-Inflammatory Cytokines in Conditions of "Social" Stress
Anna L. Yasenyavskaya, М. А. Самотруева, А. А. Цибизова et al. · Current Drug Therapy · 2022
- Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
Michele F. M. Sciacca, Налетова Ирина Николаевна, Maria Laura Giuffrida et al. · ACS Chemical Neuroscience · 2022
Study in humansOpen access · CC BY17 citationsRead the open copy →
- The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress
Anna L. Yasenyavskaya, М. А. Самотруева, Nikolai F. Myasoedov et al. · European Pharmaceutical Journal · 2022
Open access · CC BY-NC-ND1 citationsRead the open copy →
- Physiological effects of Semax, a synthetic analogue of ACTH4–10: Experience and prospects for applications
Svetlana E. Zhuikova · Integrative Physiology · 2022
Open access · CC BY-NC5 citationsRead the open copy →
- SEMAX - APPLICATION PROSPECTS (brief overview message)
K. Hadarceva, Elena Belyaeva · Clinical Medicine and Pharmacology · 2021
1 citations
- P.0746 Effects of the ACTH(4-10) analogue semax in a model of hypoxic brain damage in 10-day-old rat pups
D. Khukhareva, Natalia Evdokimova, Elena A. Sebentsova et al. · European Neuropsychopharmacology · 2021
- P.0038 Adrenocorticotropic hormone (4-10) analogue semax attenuates the effects of neonatal antidepressant fluvoxamine exposure on the social behaviour in pre-adolescent rats
A. Monicheva, Nataliya Yu. Glazova, Д. М. Манченко et al. · European Neuropsychopharmacology · 2021
- Neuroimaging of the Intracentral Brain of Cats by Normalization of Electrograms under the Action of Semax
Yu. V. Fokin, М. М. Борисова, S. Yu. Kharitonov · Journal Biomed · 2021
Open access · CC BY1 citationsRead the open copy →
- Subchronic Administration of Noopept and Semax Peptides Increases the Density of Cortical GABAA-Receptors in the Brain of BALB/c Mice
Екатерина Валерьевна Васильева, Алия Анвяровна Абдуллина, Georgy I. Kovalev · Neurochemical Journal · 2021
2 citations
- Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion
Olga Yu. Sudarkina, Ivan B. Filippenkov, Vasily V. Stavchansky et al. · International Journal of Molecular Sciences · 2021
Animal studyOpen access · CC BY15 citationsRead the open copy →
- The Peptide Drug ACTH(4–7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain
Lyudmila V. Dergunova, Veronika G. Dmitrieva, Ivan B. Filippenkov et al. · Molecular Biology · 2021
8 citations
- Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)
Maria V. Svishcheva, Ye. S. Mishina, О. А. Медведева et al. · Bulletin of Experimental Biology and Medicine · 2021
Animal study8 citations
- Semax, synthetic ACTH(4–10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats
Nataliya Yu. Glazova, Д. М. Манченко, Maria A. Volodina et al. · Neuropeptides · 2020
Animal study8 citations
- Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress
Maria V. Svishcheva, Александра Юрьевна Мухина, О. А. Медведева et al. · Bulletin of Experimental Biology and Medicine · 2020
Animal study10 citations
- Predominance of Nootropic or Anxiolytic Effects of Selank, Semax, and Noopept Peptides Depending on the Route of Administration to BALB/c and С57BL/6 Mice
Екатерина Валерьевна Васильева, Е. А. Кондрахин, Алия Анвяровна Абдуллина et al. · Neurochemical Journal · 2020
6 citations
- Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats
Ivan B. Filippenkov, Vasily V. Stavchansky, Alina E. Denisova et al. · Genes · 2020
Study in humansOpen access · CC BY29 citationsRead the open copy →
- Investigation of the mechanism of the neuroprotective effect of the peptide preparation Semax in rat brain under conditions of ischemia-reperfusion
Olga Yu. Sudarkina, Veronika G. Dmitrieva, Ivan B. Filippenkov et al. · Nauchno-prakticheskii zhurnal «Medicinskaia genetika» · 2020
Open access · CC BYRead the open copy →
- The Administration of Semax and HLDF-6 Peptides to Rats Regulates Protein Synthesis Rhythm in Hepatocytes and Corrects Senescent Disturbances
V. Y. Brodsky, Yu. A. Zolotarev, Ludmila A. Malchenko et al. · Russian Journal of Developmental Biology · 2020
5 citations
- Structural transformations of thermal burn wounds in rats under the influence of Semax and Selank neuropeptides
Альфия Кадыровна Ажикова, Фельдман Бронислав Владимирович, A. A. Andreeva et al. · Pharmacy & Pharmacology · 2020
Open access · CC BYRead the open copy →
- Functional Connectomic Approach to Studying Selank and Semax Effects
Yana R. Panikratova, И. С. Лебедева, Oleg Yu. Sokolov et al. · Doklady Biological Sciences · 2020
Study in humans5 citations
Each list shows up to 40 papers.See all 179 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.