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KPV studies

106 journal papers mention KPV in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.

Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether KPV is safe, effective or approved for any use.

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Papers
106
106 articles, 0 reviews
Earliest paper
1961
Most papers in 2003 (6)
Open access
23%
free to read somewhere
Reviews
0%
of all papers listed

What kind of studies

Of 77 papers in PubMed that mention KPV in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.

  • Randomized controlled trials0
  • Other clinical trials0
  • Meta-analyses and systematic reviews0
  • Other reviews0
  • Case reports0
  • Animal studies only41
  • Studies in humans25

Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).

Papers per year

1996 to 2025, peak 6 papers in a year. The latest year may still be incomplete.

1996: 4 papers1997: 5 papers1998: 1 papers1999: 0 papers2000: 0 papers2001: 2 papers2002: 3 papers2003: 6 papers2004: 2 papers2005: 2 papers2006: 4 papers2007: 4 papers2008: 3 papers2009: 1 papers2010: 1 papers2011: 2 papers2012: 0 papers2013: 1 papers2014: 0 papers2015: 1 papers2016: 2 papers2017: 1 papers2018: 0 papers2019: 2 papers2020: 0 papers2021: 1 papers2022: 1 papers2023: 0 papers2024: 1 papers2025: 2 papers19962025

Where it is published

  1. Journal of Medicinal Chemistry10 papers
  2. Peptides9 papers
  3. Helvetica Chimica Acta5 papers
  4. Bulletin of the Chemical Society of Japan4 papers
  5. ChemInform3 papers

The papers

ShowAllOpen accessReviews

Most citedName in the title

  1. Cyclic melanotropins. 5. Importance of the C-terminal tripeptide (Lys-Pro-Val)

    Wayne L. Cody, Brian C. Wilkes, Brian J. Muska et al. · Journal of Medicinal Chemistry · 1984

    Animal study21 citations

  2. Synthese von Peptid‐Zwischenprodukten für den Aufbau eines corticotrop wirksamen Nonadecapeptids. IV. Derivate der Nonapeptidsequenz Lys‐Pro‐Val‐Gly‐Lys‐Lys‐Arg‐Arg‐Pro

    Werner RITTEL · Helvetica Chimica Acta · 1962

    15 citations

  3. Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

    Kasturi R. Pawar, Chandra Sekhar Kolli, Vijaya Kumar Rangari et al. · Journal of Pharmaceutical Sciences · 2017

    Study in humans13 citations

  4. Structure–antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues

    Marcelo F. Masman, Csaba Somlai, Francisco M. Garibotto et al. · Bioorganic & Medicinal Chemistry · 2008

    8 citations

  5. Syntheses of Peptides Related to the N-Terminal Structure of Corticotropin. II. Synthesis of Gly-Lys-Pro-Val Sequence

    Ken Inouye, Hideo Ōtsuka · Bulletin of the Chemical Society of Japan · 1961

    6 citations

  6. Syntheses of Peptides Related to the N-Terminal Structure of Corticotropin. IV. The Synthesis of the Amino Acid Sequences, Lys-Pro-Val-Gly and Lys-Pro-Val-Gly-Lys

    Hideo Ōtsuka, Ken Inouye, Yoshiko Jono · Bulletin of the Chemical Society of Japan · 1964

    5 citations

  7. Conformational analysis of tripeptide Ac-Lys-Pro-Val-NH2, COOH-terminal sequence of alpha-MSH

    Philippe Chavatte, Saı̈d Yous, Daniel Lesieur et al. · Journal of Pharmacy and Pharmacology · 2001

    3 citations

  8. ChemInform Abstract: CYCLIC MELANOTROPINS. 5. IMPORTANCE OF THE C‐TERMINAL TRIPEPTIDE (LYS‐PRO‐VAL)

    Wayne L. Cody, Brian C. Wilkes, Brian J. Muska et al. · ChemInform · 1985

LatestName in title or abstract

  1. C-terminal tripeptide KPV of α-MSH modulates the selectivity of melanotropins in the melanocortin system

    Joel Nyberg, Adrian Drake De la Peña, Jennifer Bao et al. · Australian Journal of Chemistry · 2025

    1 citations

  2. Multicompartmental Hydrogel Microspheres with a Concentric Thin Oil Layer: Protecting and Targeting Therapeutic Agents for Inflammatory Bowel Disease

    Hye‐Seon Jeong, Yoon Young Choi, Do Wan Kim et al. · ACS Applied Bio Materials · 2025

    Study in humans5 citations

  3. Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers

    Dingwei Li, Jianxun Shangguan, Fengnan Yu et al. · ACS Applied Materials & Interfaces · 2024

    Animal study25 citations

  4. A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

    Ying‐Zheng Zhao, Pengpeng Xue, Gaolong Lin et al. · Acta Biomaterialia · 2022

    Animal study39 citations

  5. Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats

    Jie Lena Sun, Pengpeng Xue, Jiayi Liu et al. · ACS Biomaterials Science & Engineering · 2021

    Animal study23 citations

  6. Are melanocortin peptides future therapeutics for cutaneous wound healing?

    Markus Böhm, Thomas Anton Luger · Experimental Dermatology · 2019

    Study in humansOpen access14 citationsRead the open copy →

  7. A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis

    Ya Wu, Minghui Sun, Dan Wang et al. · Biomaterials Science · 2019

    Animal study62 citations

  8. Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

    Kasturi R. Pawar, Chandra Sekhar Kolli, Vijaya Kumar Rangari et al. · Journal of Pharmaceutical Sciences · 2017

    Study in humans13 citations

  9. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

    Minying Cai, Victor J. Hruby · Current Protein and Peptide Science · 2016

    ReviewOpen access56 citationsRead the open copy →

  10. Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model

    Émilie Viennois, Sarah A. Ingersoll, Saravanan Ayyadurai et al. · Cellular and Molecular Gastroenterology and Hepatology · 2016

    Open access · CC BY-NC-ND35 citationsRead the open copy →

  11. Purification and identification of antioxidant and ACE-inhibitory peptide from Saccharomyces cerevisiae protein hydrolysate

    Mahta Mirzaei, Saeed Mirdamadi, M R Ehsani et al. · Journal of Functional Foods · 2015

    Open access · CC BY-NC-ND140 citationsRead the open copy →

  12. The Synthetic Melanocortin (CKPV)2 Exerts Anti-Fungal and Anti-Inflammatory Effects against Candida albicans Vaginitis via Inducing Macrophage M2 Polarization

    Haixia Ji, Yulian Zou, Jingjing Duan et al. · PLoS ONE · 2013

    Study in humansOpen access · CC BY21 citationsRead the open copy →

  13. Nanotechnology-based drug delivery in mucosal immune diseases: hype or hope?

    Elke Cario · Mucosal Immunology · 2011

    Open access12 citationsRead the open copy →

  14. A sucrose-derived scaffold for multimerization of bioactive peptides

    Rao Venkataramanarao, Ramesh Alleti, Liping Xu et al. · Bioorganic & Medicinal Chemistry · 2011

    Open access11 citationsRead the open copy →

  15. Biogenics

    Motoi Tamura · NIPPON SHOKUHIN KOGYO GAKKAISHI · 2010

    Open accessRead the open copy →

  16. Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

    Hamed Laroui, Guillaume Dalmasso, Hang Thi Thu Nguyen et al. · Gastroenterology · 2009

    Study in humansOpen access255 citationsRead the open copy →

  17. Structure–antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues

    Marcelo F. Masman, Csaba Somlai, Francisco M. Garibotto et al. · Bioorganic & Medicinal Chemistry · 2008

    8 citations

  18. Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-d/l-Val sequence in Gram-positive and Gram-negative bacteria

    Mirren Charnley, Arthur J.G. Moir, C.W.I. Douglas et al. · Peptides · 2008

    Study in humans22 citations

  19. PepT1 mediated tripeptide KPV uptake reduces intestinal inflammation

    Guillaume Dalmasso, Laetitia Charrier‐Hisamuddin, Hang Thi Thu Nguyen et al. · Inflammatory Bowel Diseases · 2008

    1 citations

  20. PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

    Guillaume Dalmasso, Laetitia Charrier‐Hisamuddin, Hang Thi Thu Nguyen et al. · Gastroenterology · 2007

    Study in humansOpen access122 citationsRead the open copy →

  21. PepT1‐mediated anti‐inflammatory tri‐peptide (KPV) transport reduces intestinal inflammation

    Guillaume Dalmasso, Pallavi Garg, Shanthi V. Sitaraman et al. · The FASEB Journal · 2007

  22. Potent and selective agonists of α-melanotropin (αMSH) action at human melanocortin receptor 5; linear analogs of α-melanotropin

    Maria A. Bednarek, Tanya MacNeil, Rui Tang et al. · Peptides · 2007

    Study in humans13 citations

  23. Structure–function Relationships and Conformational Properties of α‐MSH(6–13) Analogues with Candidacidal Activity

    Alfonso Carotenuto, Maria Rosaria Saviello, Luigia Auriemma et al. · Chemical Biology & Drug Design · 2007

    13 citations

  24. Binding of Anti-Inflammatoryα-Melanocyte-Stimulating-Hormone Peptides and Proinflammatory Cytokines to Receptors on Melanoma Cells

    Krzysztof Lyson, Giuliana Ceriani, Akira Takashima et al. · NeuroImmunoModulation · 2006

    Animal study20 citations

  25. New Melanocortin 1 Receptor Binding Motif Based on the C‐Terminal Sequence of α‐Melanocyte‐Stimulating Hormone

    Helgi B. Schiöth, Ruta Muceniece, Ilga Mutule et al. · Basic & Clinical Pharmacology & Toxicology · 2006

    Study in humans3 citations

  26. Therapeutischer Effekt des Tripeptids KDPT im murinen DSS-Kolitis Modell

    C. Maaser, D Bettenwoth, Andreas Lügering et al. · Zeitschrift für Gastroenterologie · 2006

    2 citations

  27. Inhibitory Effects of the Peptide (CKPV)2 on Endotoxin-Induced Host Reactions

    Stefano Gatti, Andrea Carlin, Andrea Sordi et al. · Journal of Surgical Research · 2006

    Animal study20 citations

  28. Three‐dimensional structure of the α‐MSH‐derived candidacidal peptide [Ac‐CKPV]2

    Anna P. Catania, Paolo Grieco, Antonio Randazzo et al. · Journal of Peptide Research · 2005

    16 citations

  29. Das Tripeptid KPV zeigt eine antiinflammatorische Wirkung in murinen Kolitismodellen

    Christian Maaser, Klaus Kannengießer, Andreas Lügering et al. · Zeitschrift für Gastroenterologie · 2005

  30. Antioxidant and anti‐inflammatory activities of melanocortin peptides

    John W. Haycock, Rebecca P. Hill, Richard J. R. Elliott et al. · Experimental Dermatology · 2004

  31. α-Melanocyte-Stimulating Hormone, MSH 11–13 KPV and Adrenocorticotropic Hormone Signalling in Human Keratinocyte Cells

    Richard J. R. Elliott, Marika Szabo, Mark J. Wagner et al. · Journal of Investigative Dermatology · 2004

    Study in humansOpen access47 citationsRead the open copy →

  32. Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity

    Christine G. Joseph, Andrzej M. Wilczynski, Jerry Ryan Holder et al. · Peptides · 2003

    Study in humans15 citations

  33. Extensive structure–activity studies of lactam derivatives of MT‐II and SHU‐9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5

    Paolo Grieco, Preeti Balse, Gil Un Han et al. · Journal of Peptide Research · 2003

    Study in humans29 citations

  34. Dissection of the Anti-Inflammatory Effect of the Core and C-Terminal (KPV) α-Melanocyte-Stimulating Hormone Peptides

    Stephen J. Getting, Helgi Birgir Schiöth, Mauro Perretti · Journal of Pharmacology and Experimental Therapeutics · 2003

    Animal studyOpen access · CC BY39 citationsRead the open copy →

  35. Effects of α-melanotropin C-terminal tripeptide analogues on macrophage NO production

    Ruta Muceniece, Liga Krigere, Helga Süli‐Vargha et al. · Peptides · 2003

    Animal study11 citations

  36. Novel α-Melanocyte Stimulating Hormone Peptide Analogues with High Candidacidal Activity

    Paolo Grieco, Cláudia Rossi, Gualtiero I. Colombo et al. · Journal of Medicinal Chemistry · 2003

    34 citations

  37. Evaluation of an Imaging Platform during the Development of a FRET Protease Assay

    Jeanette George, Michelle L. Teear, Christopher G. Norey et al. · SLAS DISCOVERY · 2003

    Study in humansOpen access · CC BY-NC-ND40 citationsRead the open copy →

  38. Activity and conformation of a cyclic heptapeptide possessing the message sequence His-Phe-Arg-Trp of α-melanotropin

    Prashant V. Desai, Mamta S. Prachand, Evans C. Coutinho et al. · International Journal of Biological Macromolecules · 2002

    Animal study8 citations

  39. Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats

    Du-hu Liu, Yongping Su, Wei Zhang et al. · Burns · 2002

    Animal study18 citations

  40. Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats

    Du-hu Liu, Yongping Su, Wei Zhang et al. · Critical Care Medicine · 2002

    Animal study20 citations

Each list shows up to 40 papers.See all 106 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.