Hexarelin studies
305 journal papers mention Hexarelin in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether Hexarelin is safe, effective or approved for any use.
- Papers
- 305
- 296 articles, 9 reviews
- Earliest paper
- 1994
- Most papers in 1999 (32)
- Open access
- 22%
- free to read somewhere
- Reviews
- 3%
- of all papers listed
What kind of studies
Of 291 papers in PubMed that mention Hexarelin in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials26
- Other clinical trials32
- Meta-analyses and systematic reviews0
- Other reviews23
- Case reports1
- Animal studies only107
- Studies in humans169
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
1997 to 2026, peak 32 papers in a year. The latest year may still be incomplete.
Where it is published
- The Journal of Clinical Endocrinology & Metabolism30 papers
- Journal of Endocrinological Investigation25 papers
- Endocrinology18 papers
- Clinical Endocrinology18 papers
- European Journal of Endocrinology14 papers
The papers
Most citedName in the title
- Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man
Ezio Ghigo, Emanuela Arvat, Laura Gianotti et al. · The Journal of Clinical Endocrinology & Metabolism · 1994
Study in humansOpen access · CC BY163 citationsRead the open copy →
- Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation
I Pettersson, Giampiero Muccioli, Riccarda Granata et al. · Journal of Endocrinology · 2002
Study in humansOpen access112 citationsRead the open copy →
- Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans
G Bisi, Valerio Podio, Maria Rosa Valetto et al. · Journal of Endocrinological Investigation · 1999
Randomized trialOpen access · CC BY79 citationsRead the open copy →
- Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia
Giuseppe Sirago, Elena Conte, Flavio Fracasso et al. · Scientific Reports · 2017
Animal studyOpen access · CC BY45 citationsRead the open copy →
LatestName in title or abstract
- Peptides
Farboud Aria, Param Shah, Sean Omoseni et al. · JBJS Journal of Orthopaedics for Physician Assistants · 2026
Open access · CC BY-NC-NDRead the open copy →
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration
Aleksander Dominikowski, Zofia Rękoś, Michał Olejarz et al. · Frontiers in Endocrinology · 2026
ReviewOpen access · CC BY1 citationsRead the open copy →
- Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection
Kevin B. S. Chow · Indian Journal of Pharmacology · 2026
Animal studyOpen access · CC BY-NC-NDRead the open copy →
- Growth Hormone Secretagogues: Between Endocrine Physiology and the Therapeutic Frontier of GH-IGF-1 Axis-Modulating Peptides
Pedro Augusto Zaiats, Pedro Henrique Rodrigues Senteio, Diego Ribeiro et al. · Open Journal of Clinical Diagnostics · 2026
Open access · CC BYRead the open copy →
- Hexarelin modulates stress effects on ghrelin system activity in growing lambs
K Pierzchała, Colin Guy Scanes, Alina Gajewska · Folia Biologica · 2024
Open access · CC BYRead the open copy →
- Pharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor modulator
Jade Gauvin, David N. Huynh, Isabelle Dubuc et al. · Frontiers in Pharmacology · 2024
Open access · CC BY3 citationsRead the open copy →
- Effects of hexarelin and isolation stress on the Met-enkephalin system in young lambs
K. Koziec, Colin Guy Scanes, Joanna Zubel–Łojek et al. · Folia Biologica · 2023
Open access · CC BYRead the open copy →
- Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway
Guan Chen, Chenyu Li, Xuefei Shen et al. · European journal of medical research · 2023
Animal studyOpen access · CC BY14 citationsRead the open copy →
- Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein
Ramona Meanti, Martina Licata, Laura Rizzi et al. · International Journal of Molecular Sciences · 2023
Study in humansOpen access · CC BY4 citationsRead the open copy →
- Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts
Shakhawath Hossain, Rosita Kneiszl, Per Larsson · Nanoscale · 2023
Open access · CC BY21 citationsRead the open copy →
- Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe et al. · Frontiers in Physiology · 2022
Open access · CC BY2 citationsRead the open copy →
- Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury
Vanessa Zambelli, Laura Rizzi, Paolo Delvecchio et al. · Drug Target Insights · 2021
Open access · CC BY-NC7 citationsRead the open copy →
- Cardioprotective role of myocardial endothelial nitric oxide synthase and serum nitric oxide induced by hexarelin in rats with myocardial infarction-induced heart failure
Elvis Agbo, Dong Liu, Jia Wan Liao et al. · Iranian Red Crescent Medical Journal · 2021
Open access · CC BY-NCRead the open copy →
- Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide—Induced Apoptotic Toxicity
Ramona Meanti, Laura Rizzi, Elena Bresciani et al. · Pharmaceuticals · 2021
Open access · CC BY12 citationsRead the open copy →
- Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
David Dahlgren, Tobias Olander, Markus Sjöblom et al. · Acta Pharmaceutica Sinica B · 2021
Open access · CC BY-NC-ND29 citationsRead the open copy →
- Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice
Zhengxiang Huang, Xuehan Lu, Lili Huang et al. · The FASEB Journal · 2020
Animal studyOpen access17 citationsRead the open copy →
- Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats
Tayfun Baser, Ercan Özdemir, Ahmet Kemal Filiz et al. · Canadian Journal of Physiology and Pharmacology · 2020
Open access24 citationsRead the open copy →
- P0519HEXARELIN PROTECTS ISCHEMIA REPERFUSION INDUCED ACUTE KIDNEY INJURY BY TARGETING 14-3-3Σ
Guan Chen, Yan Hua Xu · Nephrology Dialysis Transplantation · 2020
Open accessRead the open copy →
- Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion
H. McDonald, Jason N. Peart, Nyoman Dana Kurniawan et al. · Biomedicine & Pharmacotherapy · 2020
Animal studyOpen access · CC BY-NC-ND12 citationsRead the open copy →
- The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
David Dahlgren, Markus Sjöblom, Mikael Hedeland et al. · Pharmaceutics · 2020
Open access · CC BY25 citationsRead the open copy →
- Evaluation of Hexarelin Effects on Epileptic Seizures, Hippocampal Neuronal Damage and Memory Impairment after Pentylenetetrazole-Induced Acute Model in Rat
Ahmet Altun · American Journal of Biomedical Science & Research · 2019
Open access · CC BY1 citationsRead the open copy →
- Hexarelin protects cardiac H9C2 cells from angiotensin II-induced hypertrophy via the regulation of autophagy
E. Agbo, Mingxing Li, Y-Q Wang et al. · Die Pharmazie · 2019
Animal studyOpen access · CC BY10 citationsRead the open copy →
- Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats
Elvis Agbo, Donghai LIU, Meixiu Li et al. · TURKISH JOURNAL OF MEDICAL SCIENCES · 2019
Animal studyOpen access · CC BY9 citationsRead the open copy →
- Characterization of a third ghrelin receptor, GHS-R3a, in channel catfish reveals novel expression patterns and a high affinity for homologous ligand
Brian C. Small, Sylvie M. A. Quiniou, Hiroyuki Kaiya et al. · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · 2018
Study in humansOpen access8 citationsRead the open copy →
- Enhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats
Xinli Zhang, Jin‐Kui Yang, Chen Chen · International Journal of Molecular Sciences · 2018
Animal studyOpen access · CC BY4 citationsRead the open copy →
- The CD36-PPARγ Pathway in Metabolic Disorders
Loïze Maréchal, Maximilien Laviolette, Amélie Rodrigue‐Way et al. · International Journal of Molecular Sciences · 2018
ReviewOpen access · CC BY171 citationsRead the open copy →
- Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction
Hayley McDonald, Jason N. Peart, Nyoman Dana Kurniawan et al. · Physiological Reports · 2018
Animal studyOpen access · CC BY23 citationsRead the open copy →
- Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats
Xinli Zhang, Linbing Qu, Ling Chen et al. · Physiological Reports · 2018
Animal studyOpen access · CC BY5 citationsRead the open copy →
- Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia
Giuseppe Sirago, Elena Conte, Flavio Fracasso et al. · Scientific Reports · 2017
Animal studyOpen access · CC BY45 citationsRead the open copy →
- Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice
Rasha Mosa, Lili Huang, Yeda Wu et al. · Endocrinology · 2017
Animal studyOpen access11 citationsRead the open copy →
- Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin‐induced cachexia
Elena Conte, Giulia Maria Camerino, Antonietta Mele et al. · Journal of Cachexia Sarcopenia and Muscle · 2017
Animal studyOpen access · CC BY-NC69 citationsRead the open copy →
- The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway
Jiannan Huang, Yi Li, Juan Zhang et al. · International Heart Journal · 2017
Animal studyOpen access23 citationsRead the open copy →
- JMV2894, a novel growth hormone secretagogue, accelerates body mass recovery in an experimental model of cachexia
Elena Bresciani, Laura Rizzi, Laura Molteni et al. · Endocrine · 2016
Animal studyOpen access · CC BY16 citationsRead the open copy →
- Hexarelin Protects Rodent Pancreatic Β-Cells Function from Cytotoxic Effects of Streptozotocin Involving Mitochondrial Signalling Pathways In Vivo and In Vitro
Yan Zhao, Xinli Zhang, Jiezhong Chen et al. · PLoS ONE · 2016
Animal studyOpen access · CC BY12 citationsRead the open copy →
Each list shows up to 40 papers.See all 305 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.