GHRP-2 studies
208 journal papers mention GHRP-2 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether GHRP-2 is safe, effective or approved for any use.
- Papers
- 208
- 202 articles, 6 reviews
- Earliest paper
- 1993
- Most papers in 1998 (19)
- Open access
- 40%
- free to read somewhere
- Reviews
- 3%
- of all papers listed
What kind of studies
Of 206 papers in PubMed that mention GHRP-2 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials42
- Other clinical trials14
- Meta-analyses and systematic reviews0
- Other reviews19
- Case reports5
- Animal studies only61
- Studies in humans133
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
1997 to 2026, peak 19 papers in a year. The latest year may still be incomplete.
Where it is published
- The Journal of Clinical Endocrinology & Metabolism35 papers
- Endocrine Journal13 papers
- Endocrinology10 papers
- European Journal of Endocrinology10 papers
- American Journal of Physiology-Endocrinology and Metabolism8 papers
The papers
Most citedName in the title
- Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats
Miriam Granado, Teresa Priego, Ana Isabel Martı́n et al. · American Journal of Physiology-Endocrinology and Metabolism · 2004
Animal studyOpen access172 citationsRead the open copy →
- Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle
Miriam Granado, Teresa Priego, Ana Isabel Martı́n et al. · American Journal of Physiology-Endocrinology and Metabolism · 2005
Animal studyOpen access58 citationsRead the open copy →
- Growth Hormone Releasing Peptide-2 (GHRP-2), Like Ghrelin, Increases Food Intake in Healthy Men
Blandine Laferrère, Cynthia Abraham, Colleen D. Russell et al. · The Journal of Clinical Endocrinology & Metabolism · 2005
Study in humansOpen access55 citationsRead the open copy →
- Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation
Rui Hu, Zhisheng Wang, Quanhui Peng et al. · PLoS ONE · 2016
Randomized trialOpen access · CC BY30 citationsRead the open copy →
- Characteristics of Growth Hormone Secretion Responsiveness to Growth Hormone-Releasing Peptide-2 (GHRP-2 or KP102) in Calves.
Sanggun Roh, Nobuyoshi MATSUNAGA, Satoshi Hidaka et al. · Endocrine Journal · 1996
Animal studyOpen access28 citationsRead the open copy →
- The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: A comparison
Yasuyuki Kinoshita, Atsushi Tominaga, Satoshi Usui et al. · Endocrine Journal · 2012
Study in humansOpen access13 citationsRead the open copy →
- Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2
Takashi Kimura, Akira Shimatsu, Hiroshi Arimura et al. · Endocrine Journal · 2010
Case reportOpen access13 citationsRead the open copy →
- Effect of Growth Hormone‐Releasing Peptide‐2 (GHRP‐2) and GH‐Releasing Hormone (GHRH) on the cAMP Levels and GH Release from Cultured Acromegalic Tumours
Chen Chen, Michael Pullar, Kylie Loneragan et al. · Journal of Neuroendocrinology · 1998
Study in humansOpen access13 citationsRead the open copy →
- Increased Growth Velocity During Prolonged Ghrp-2 Administration To Growth Hormone Deficient Children (Ghd)
Verónica Merico, FERNANDO G. CASSORLA, Teresa Salazar et al. · Pediatric Research · 1997
Open access6 citationsRead the open copy →
- Growth Hormone-Releasing Peptide-2 (GHRP-2) Acts Synergistically with Growth Hormone-Releasing Hormone (GHRH) to Release Growth Hormone (GH) in Swine
Phùng Thăng Long, Nobuyoshi MATSUNAGA, Satoshi Hidaka et al. · Nihon Chikusan Gakkaiho · 2001
Open access4 citationsRead the open copy →
- Effects of Muscarinic and Adrenergic Blockade on Growth Hormone Secretion Induced by Growth Hormone-Releasing Peptide-2 (GHRP-2) in Ovariectomized Ewes.
Sanggun Roh, MINORU HIROTA, Mao Long HE et al. · Endocrine Journal · 1997
Animal studyOpen access3 citationsRead the open copy →
- Is there an undiscovered neurocircuit for regulating GH secretion? -Pitfalls of GHRP-2 and ITT as GH provocative tests-
Kyuzi Kamoi, Akira Shimatsu, Mai Kobayashi · Endocrine Journal · 2010
Case reportOpen access2 citationsRead the open copy →
- Factors Other than Sex Steroids Modulate GHRH and GHRP-2 Efficacies in Men: Evaluation Using a GnRH Agonist/Testosterone Clamp
Johannes D. Veldhuis, Cyril Y. Bowers · The Journal of Clinical Endocrinology & Metabolism · 2009
Randomized trialOpen access2 citationsRead the open copy →
LatestName in title or abstract
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration
Aleksander Dominikowski, Zofia Rękoś, Michał Olejarz et al. · Frontiers in Endocrinology · 2026
ReviewOpen access · CC BY1 citationsRead the open copy →
- Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone
Yuki Otsuka, Yoshiaki Soejima, Yasuhiro Nakano et al. · International Journal of Molecular Sciences · 2026
Study in humansOpen access · CC BY1 citationsRead the open copy →
- Growth Hormone Secretagogues: Between Endocrine Physiology and the Therapeutic Frontier of GH-IGF-1 Axis-Modulating Peptides
Pedro Augusto Zaiats, Pedro Henrique Rodrigues Senteio, Diego Ribeiro et al. · Open Journal of Clinical Diagnostics · 2026
Open access · CC BYRead the open copy →
- Differentiating hypothalamic from pituitary adrenal insufficiency: underlying causes and diagnostic utility of the corticotropin-releasing hormone and growth hormone-releasing peptide-2 stimulation tests
Nanami Okada, Tomoko Nakagawa, Noboru Murahashi et al. · Endocrine Journal · 2026
Open access · CC BY-NC-NDRead the open copy →
- (197) Peptides in Practice: Evaluating Efficacy and Safety in Men’s Health
R Arora, Arjun K. Venkatesh, Gene Austin Krishingner et al. · The Journal of Sexual Medicine · 2025
Open accessRead the open copy →
- MON-030 A Case of Idiopathic Arginine Vasopressin Deficiency Diagnosed Following Worsening of Thirst, Polydipsia, and Polyuria During Chemotherapy
Naoko Iwata, Yusuke S. Kato, Omi Murase et al. · Journal of the Endocrine Society · 2025
Open access · CC BY-NC-NDRead the open copy →
- One Case of Sudden Isolated Adrenocorticotropic Hormone (ACTH) Deficiency Diagnosed Based on Repeated Hypoglycemic Attacks
Tomohide Sato · Cureus · 2025
Case reportOpen access · CC BYRead the open copy →
- Benchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism
Tatsuma Kondo, Hidetaka Suga, Kazuhito Takeuchi et al. · Diseases · 2025
Open access · CC BYRead the open copy →
- THU069 Growth Hormone Secretion And Serum High-sensitivity C-reactive Protein Levels In Adult Patients With Non-functioning Pituitary Tumors
Yasufumi Seki, Satoshi Morimoto, Kanako Bokuda et al. · Journal of the Endocrine Society · 2023
Open access · CC BY-NC-NDRead the open copy →
- Assessment of anterior pituitary reserve capacity based on growth hormone response to growth hormone-releasing peptide-2 test in the elderly
Shinichiro Teramoto, Shigeyuki Tahara, Yujiro Hattori et al. · Growth Hormone & IGF Research · 2023
Study in humansOpen accessRead the open copy →
- ODP323 Increased Serum High-Sensitivity C-Reactive Protein Levels in Adult Growth Hormone Deficient Patients with Non-Functioning Pituitary Tumors
Yasufumi Seki, Noriyoshi Takano, Kaoru Yamashita et al. · Journal of the Endocrine Society · 2022
Open access · CC BY-NC-NDRead the open copy →
- Cushing病患者に対するGHRP-2負荷試験でのGHおよびACTH反応性の特徴
皓平 大國, 彰 竹下, 由紀子 五嶋 et al. · Folia Endocrinologica Japonica · 2022
Open accessRead the open copy →
- Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors
Yasufumi Seki, Atsuhiro Ichihara · PLoS ONE · 2022
Study in humansOpen access · CC BY3 citationsRead the open copy →
- Refractory hypoglycaemia in a localised gastrointestinal stromal tumour: Case report
Arkadeep Dhali, Sukanta Ray, Gopal Krishna Dhali et al. · International Journal of Surgery Case Reports · 2021
Open access · CC BY-NC-ND5 citationsRead the open copy →
- Increased Serum High-Sensitivity C-Reactive Protein in Growth Hormone-Deficient Patients With Non-Functioning Pituitary Tumors
Yasufumi Seki, Atsuhiro Ichihara · Journal of the Endocrine Society · 2021
Open access · CC BY-NC-ND1 citationsRead the open copy →
- MON-285 Clinical Characteristics of Six Patients with Infundibulo-Neurohypophysitis
Keiko Nao, Izumi Fukuda, Tomoko Nagamine et al. · Journal of the Endocrine Society · 2020
Open access · CC BY-NC-NDRead the open copy →
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males
Deepankar K. Sinha, Adithya Balasubramanian, Alexander J. Tatem et al. · Translational Andrology and Urology · 2020
ReviewOpen access · CC BY-NC-ND11 citationsRead the open copy →
- Preoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas
Akimi Soga, Izumi Fukuda, Shunsuke Kobayashi et al. · Endocrine Journal · 2019
Study in humansOpen access6 citationsRead the open copy →
- SAT-458 Effects of Obesity and Renal Function on Pituitary Function Tests in Patients with Nonfunctioning Pituitary Tumor
Yasufumi Seki, Atsuhiro Ichihara · Journal of the Endocrine Society · 2019
Open access · CC BY-NC-NDRead the open copy →
- β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress
Deepali Gupta, Jen-Chieh Chuang, Bharath Kumar Mani et al. · Neuropsychopharmacology · 2019
Animal studyOpen access37 citationsRead the open copy →
- Evaluation of growth hormone-releasing peptide-2 for diagnosis of thyrotropin-producing pituitary adenomas
Kazunori Kageyama, Satoru Sakihara, Wataru Kameda et al. · Endocrine Journal · 2018
Study in humansOpen access2 citationsRead the open copy →
- Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels
John Tucker Sigalos, Alexander W. Pastuszak, Andrew Allison et al. · American Journal of Men s Health · 2017
Study in humansOpen access · CC BY-NC3 citationsRead the open copy →
- Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells
Yi-Ning Chao, David Sun, Yen‐Chun Peng et al. · International Journal of Molecular Sciences · 2016
Study in humansOpen access · CC BY5 citationsRead the open copy →
- MP76-09 GROWTH HORMONE RELEASING PEPTIDE TREATMENT IN MEN INCREASES SERUM INSULIN-LIKE GROWTH FACTOR-1 LEVELS
John Tucker Sigalos, Andrew Allison, Alexander W. Pastuszak et al. · The Journal of Urology · 2016
Open accessRead the open copy →
- Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation
Rui Hu, Zhisheng Wang, Quanhui Peng et al. · PLoS ONE · 2016
Randomized trialOpen access · CC BY30 citationsRead the open copy →
- Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure
Hiroshi Arimura, Hiroshi Hashiguchi, Kiyoaki Yamamoto et al. · Endocrine Journal · 2016
Clinical trialOpen access11 citationsRead the open copy →
- Synthesis of Mono-PEGylated Growth Hormone Releasing Peptide-2 and Investigation of its Biological Activity
Xiaoyu Hu, Beihua Xu, Ziniu Zhou · AAPS PharmSciTech · 2015
Animal studyOpen access2 citationsRead the open copy →
- Increased Secretion of Endogenous GH after Treatment with an Intranasal GH-releasing Peptide-2 Spray Does Not Promote Growth in Short Children with GH Deficiency
Toshiaki Tanaka, Yukihiro Hasegawa, Susumu Yokoya et al. · Clinical Pediatric Endocrinology · 2014
Open access · CC BY-NC-ND5 citationsRead the open copy →
- Adult Growth Hormone Deficiency: Current Concepts
Izumi Fukuda, Naomi Hizuka, Toko Muraoka et al. · Neurologia medico-chirurgica · 2014
ReviewOpen access · CC BY-NC-ND29 citationsRead the open copy →
- Differential pulsatile secretagogue control of GH secretion in healthy men
Catalina Norman, John Miles, Cyril Y. Bowers et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2013
Randomized trialOpen access5 citationsRead the open copy →
Each list shows up to 40 papers.See all 208 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.