FOXO4-DRI studies
25 journal papers mention FOXO4-DRI in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether FOXO4-DRI is safe, effective or approved for any use.
- Papers
- 25
- 22 articles, 3 reviews
- Earliest paper
- 2017
- Most papers in 2026 (4)
- Open access
- 72%
- free to read somewhere
- Reviews
- 12%
- of all papers listed
What kind of studies
Of 19 papers in PubMed that mention FOXO4-DRI in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials0
- Other clinical trials0
- Meta-analyses and systematic reviews0
- Other reviews5
- Case reports0
- Animal studies only5
- Studies in humans9
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Papers per year
2017 to 2026, peak 4 papers in a year. The latest year may still be incomplete.
Where it is published
- Naunyn-Schmiedeberg s Archives of Pharmacology2 papers
- Frontiers in Bioengineering and Biotechnology2 papers
- Cell1 papers
- Circulation1 papers
- Experimental Gerontology1 papers
The papers
Most citedName in the title
- FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
Chi Zhang, Yun Xie, Haicheng Chen et al. · Aging · 2020
Animal studyOpen access · CC BY93 citationsRead the open copy →
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes
Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk et al. · Frontiers in Bioengineering and Biotechnology · 2021
Open access · CC BY55 citationsRead the open copy →
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Benjamin M. R. Bourgeois, Emil Spreitzer, Daniel Platero-Rochart et al. · Nature Communications · 2025
Study in humansOpen access · CC BY21 citationsRead the open copy →
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
Yu-Xiang Kong, Zhi-Shuai Li, Yuanbo Liu et al. · Communications Biology · 2025
Study in humansOpen access · CC BY-NC-ND21 citationsRead the open copy →
- FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells
Yanqing Li, Chi Zhang, Haicheng Cheng et al. · Experimental Gerontology · 2024
Animal studyOpen access · CC BY13 citationsRead the open copy →
- FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway
Zhicheng Hu, F. Li, Chunyi Hu et al. · Frontiers in Bioengineering and Biotechnology · 2026
Open access · CC BY1 citationsRead the open copy →
- FOXO4-DRI ALLEVIATES AGE-RELATED TESTOSTERONE SECRETION INSUFFICIENCY VIA TARGETING SENESCENT LEYDIG CELLS IN AGED MICE
Guihua Liu, Xing Yang, Tingting Li · Fertility and Sterility · 2020
Open access1 citationsRead the open copy →
LatestName in title or abstract
- FOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting
Diana-Maria Mateescu, Dragos-Mihai Gavrilescu, Adelina-Raluca Marinescu et al. · Antioxidants · 2026
ReviewOpen access · CC BYRead the open copy →
- Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence
Na Ning, Changtu Wang, Tingyu Gao et al. · Molecular Carcinogenesis · 2026
Study in humansOpen accessRead the open copy →
- FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway
Zhicheng Hu, F. Li, Chunyi Hu et al. · Frontiers in Bioengineering and Biotechnology · 2026
Open access · CC BY1 citationsRead the open copy →
- Pharmacology of Senolytics: Targeting Cellular Aging in Chronic Diseases
Priyanka R.Chaudhari · International Journal of Sciences and Innovation Engineering · 2025
Open access · CC BY-NCRead the open copy →
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Benjamin M. R. Bourgeois, Emil Spreitzer, Daniel Platero-Rochart et al. · Nature Communications · 2025
Study in humansOpen access · CC BY21 citationsRead the open copy →
- Aging‐Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent Cells
Honglin Xiang, Caiping Yan, Yefei Lei et al. · Advanced Functional Materials · 2025
Open access8 citationsRead the open copy →
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
Yu-Xiang Kong, Zhi-Shuai Li, Yuanbo Liu et al. · Communications Biology · 2025
Study in humansOpen access · CC BY-NC-ND21 citationsRead the open copy →
- FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells
Yanqing Li, Chi Zhang, Haicheng Cheng et al. · Experimental Gerontology · 2024
Animal studyOpen access · CC BY13 citationsRead the open copy →
- Can removal of zombie cells revitalize the aging cardiovascular system?
Seyed Soheil Saeedi Saravi, Mark W. Feinberg · European Heart Journal · 2024
Study in humansOpen access8 citationsRead the open copy →
- Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia
Xigang Jing, Shuang Jia, Maggie Teng et al. · American Journal of Respiratory Cell and Molecular Biology · 2023
Study in humansOpen access32 citationsRead the open copy →
- The 6th International Leh Symposium
Pulmonary Circulation · 2022
Open access · CC BYRead the open copy →
- FOXO4 peptide targets myofibroblast ameliorates bleomycin‐induced pulmonary fibrosis in mice through ECM‐receptor interaction pathway
Xiaodan Han, Tong Yuan, Junling Zhang et al. · Journal of Cellular and Molecular Medicine · 2022
Animal studyOpen access · CC BY39 citationsRead the open copy →
- Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis
Jingshu Meng, Yan Li, Chao Wan et al. · JCI Insight · 2021
Study in humansOpen access · CC BY119 citationsRead the open copy →
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes
Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk et al. · Frontiers in Bioengineering and Biotechnology · 2021
Open access · CC BY55 citationsRead the open copy →
- FOXO4-DRI ALLEVIATES AGE-RELATED TESTOSTERONE SECRETION INSUFFICIENCY VIA TARGETING SENESCENT LEYDIG CELLS IN AGED MICE
Guihua Liu, Xing Yang, Tingting Li · Fertility and Sterility · 2020
Open access1 citationsRead the open copy →
- FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
Chi Zhang, Yun Xie, Haicheng Chen et al. · Aging · 2020
Animal studyOpen access · CC BY93 citationsRead the open copy →
- Cellular senescence in the aging and diseased kidney
Floris A. Valentijn, Lucas L. Falke, Tri Q. Nguyen et al. · Journal of Cell Communication and Signaling · 2017
ReviewOpen access · CC BY174 citationsRead the open copy →
- Rejuvenation by Therapeutic Elimination of Senescent Cells
Paul Krimpenfort, Anton J. M. Berns · Cell · 2017
Study in humansOpen access23 citationsRead the open copy →
Each list shows up to 40 papers.See all 25 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.