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Neuro & cognitive

DSIP studies

347 journal papers mention DSIP in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.

Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether DSIP is safe, effective or approved for any use.

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Papers
347
338 articles, 9 reviews
Earliest paper
1977
Most papers in 2008 (27)
Open access
14%
free to read somewhere
Reviews
3%
of all papers listed

What kind of studies

Of 407 papers in PubMed that mention DSIP in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.

  • Randomized controlled trials5
  • Other clinical trials12
  • Meta-analyses and systematic reviews0
  • Other reviews22
  • Case reports4
  • Animal studies only287
  • Studies in humans97

Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).

Papers per year

1997 to 2026, peak 27 papers in a year. The latest year may still be incomplete.

1997: 8 papers1998: 15 papers1999: 3 papers2000: 3 papers2001: 9 papers2002: 6 papers2003: 11 papers2004: 4 papers2005: 3 papers2006: 10 papers2007: 5 papers2008: 27 papers2009: 5 papers2010: 0 papers2011: 4 papers2012: 5 papers2013: 4 papers2014: 6 papers2015: 3 papers2016: 4 papers2017: 2 papers2018: 2 papers2019: 1 papers2020: 0 papers2021: 2 papers2022: 0 papers2023: 0 papers2024: 3 papers2025: 1 papers2026: 1 papers19972026

Where it is published

  1. Bulletin of Experimental Biology and Medicine41 papers
  2. Peptides20 papers
  3. Neuroscience and Behavioral Physiology17 papers
  4. Pharmacology Biochemistry and Behavior14 papers
  5. Neuroscience Letters11 papers

The papers

ShowAllOpen accessReviews

Most citedName in the title

  1. Delta-sleep-inducing peptide (DSIP): An update

    Markus Graf, Abba J. Kastin · Peptides · 1986

    Review100 citations

  2. Delta-sleep-inducing peptide (DSIP): A review

    Markus Graf, Abba J. Kastin · Neuroscience & Biobehavioral Reviews · 1984

    Review86 citations

  3. Increased sleep following intracerebroventricular injection of the delta sleep-inducing peptide in rats

    Reidun Ursin, Mette Larsen · Neuroscience Letters · 1983

    Animal study63 citations

  4. Evidence that [125I]N-Tyr-delta sleep-inducing peptide crosses the blood-brain barrier by a non-competitive mechanism

    William A. Banks, Abba J. Kastin, David H. Coy · Brain Research · 1984

    Animal study60 citations

  5. Delta sleep-inducing peptide (DSIP): EEG and motor activity in rabbits following intravenous administration

    M Monnier, Lisa Dudler, R. Gächter et al. · Neuroscience Letters · 1977

    58 citations

  6. Delta-Sleep-Inducing Peptide: Solution Conformational Studies of a Membrane-Permeable Peptide

    Ronda A. Gray, David G. VanderVelde, Carl J. Burke et al. · Biochemistry · 1994

    56 citations

  7. Localization of neurons containing immunoreactive delta sleep-inducing peptide in the rat brain: An immunocytochemical study

    S. Feldman, Abba J. Kastin · Neuroscience · 1984

    Animal study55 citations

  8. Comparison of the effects of two ‘sleep’ peptides, delta sleep-inducing peptide and arginine-vasotocin, on single neurons in the rat and rabbit brain stem

    J. R. Normanton, J. Paul Gent · Neuroscience · 1983

    Animal study53 citations

  9. Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: Some correlations with protein binding

    William A. Banks, Abba J. Kastin, David H. Coy · Pharmacology Biochemistry and Behavior · 1982

    Animal study52 citations

  10. The delta-sleep inducing peptide (DSIP) increases duration of sleep in rats

    Sarah Kafi, M Monnier, J.-M. Gallard · Neuroscience Letters · 1979

    Animal study51 citations

  11. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide

    M Monnier, Lisa Dudler, R. Gächter et al. · Cellular and Molecular Life Sciences · 1977

    Animal study51 citations

  12. Sleep-promoting effect of the sleep-promoting substance (SPS) and delta sleep-inducing peptide (DSIP) in the mouse

    Hiroaki Nagasaki, Kunio Kitahama, J. L. Valatx et al. · Brain Research · 1980

    Animal study45 citations

  13. Characterization, Properties and Multivariate Functions of Delta-Sleep-Inducing Peptide (DSIP)

    Guido A. Schoenenberger · European Neurology · 2008

    Animal study43 citations

  14. Effect of the Delta Sleep-Inducing Peptide (DSIP) on the sleep-wakefulness cycle of cats

    Peter Polc, J. Schneeberger, W Haefely · Neuroscience Letters · 1978

    43 citations

  15. Rapid Peptide Synthesis in Liquid Phase. Preparation of Angiotensin II and Delta-sleep-inducing Peptide by the “Hold-in-Solution” Method

    Sukekatsu Nozaki, Ichiro Muramatsu · Bulletin of the Chemical Society of Japan · 1982

    40 citations

  16. Delta Sleep-Inducing Peptide in the Rat Brain: An Immunohistological Microscopic Study

    Jean Constantinidis, Constantin Bouras, Roland Guntern et al. · Neuropsychobiology · 2008

    Animal study36 citations

  17. Delta Sleep-Inducing Peptide (DSIP) stimulates Growth Hormone (GH) release in the rat by hypothalamic and pituitary actions

    Kanak S. Iyer, Samuel M. McCann · Peptides · 1987

    Animal study36 citations

  18. Radioimmunoassay of delta sleep-inducing peptide using an iodinated p-hydroxyphenylpropionic acid derivative as tracer

    Rolf Ekman, I. Larsson, MAILIS MALMQUIST et al. · Regulatory Peptides · 1983

    Study in humans34 citations

  19. In-vitro Characterization of Blood-brain Barrier Permeability to Delta Sleep-inducing Peptide

    Shamsi D. Raeissi, Kenneth L. Audus · Journal of Pharmacy and Pharmacology · 1989

    Animal study32 citations

  20. Immunohistochemical colocalization of delta sleep-inducing peptide and luteinizing hormone-releasing hormone in rabbit brain neurons

    Yves Charnay, Constantin Bouras, Philippe G. Vallet et al. · Neuroscience · 1989

    32 citations

  21. Some Pharmacological Effects of Delta-Sleep-Inducing Peptide (DSIP)

    Richard Scherschlicht, Lislott Aeppli, Peter Polc et al. · European Neurology · 2008

    Study in humans30 citations

  22. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain

    Berislav V. Zloković, Veselinka Šušić, Hugh Davson et al. · Peptides · 1989

    Animal study30 citations

  23. Delta sleep-inducing peptide (DSIP)-like material is absorbed by the gastrointestinal tract of the neonatal rat

    William A. Banks, Abba J. Kastin, David H. Coy · Life Sciences · 1983

    Animal study30 citations

  24. Decreased Delta-Sleep and Plasma Delta-Sleep-Inducing Peptide in Patients with Cushing Syndrome

    Theodore C. Friedman, Diego Garcı́a-Borreguero, Donna Hardwick et al. · Neuroendocrinology · 2008

    Study in humans29 citations

  25. Delta-sleep-inducing peptide (DSIP) as a factor facilitating animals’ resistance to acute emotional stress

    К. В. Судаков, В. Т. Иванов, Elena V. Koplik et al. · Pavlovian Journal of Biological Science · 1983

    Animal study29 citations

  26. Degradation of delta sleep inducing peptide (DSIP) and its analogs by brain extracts

    Neville Marks, Frederic Stern, Abba J. Kastin et al. · Brain Research Bulletin · 1977

    Animal study29 citations

  27. Delta-Sleep-Inducing Peptide Reduces CRF-Induced Corticosterone Release

    Markus Graf, Abba J. Kastin, David H. Coy et al. · Neuroendocrinology · 2008

    Animal study28 citations

  28. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier

    Berislav V. Zloković, M. B. Segal, Hugh Davson et al. · Peptides · 1988

    Animal study28 citations

  29. A novel 77‐residue peptide from porcine brain contains a leucine‐zipper motif and is recognized by an antiserum to delta‐sleep‐inducing peptide

    Rannar Sillard, Peter Schulz‐Knappe, Petra Vogel et al. · European Journal of Biochemistry · 1993

    Animal studyOpen access24 citationsRead the open copy →

  30. Colocalization of Delta Sleep Inducing Peptide and Luteinizing Hormone Releasing Hormone in Neurosecretory Vesicles in Rat Median Eminence

    Philippe G. Vallet, Yves Charnay, Constantin Boura et al. · Neuroendocrinology · 2008

    Animal studyOpen access · CC BY22 citationsRead the open copy →

  31. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice

    Irina G. Popovich, B O Voĭtenkov, Vladimir Nikolaevich Anisimov et al. · Mechanisms of Ageing and Development · 2003

    Animal study21 citations

  32. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia

    Elena M. Khvatova, Victor N. Samartsev, П. П. Загоскин et al. · Peptides · 2003

    Animal study21 citations

  33. Delta Sleep-Inducing Peptide (DSIP)-like Material Exists in Peripheral Organs of Rats in Large Dissociable Forms

    Markus Graf, Abba J. Kastin · Experimental Biology and Medicine · 1984

    Animal study21 citations

  34. Immunohistochemical Distribution of Delta Sleep Inducing Peptide in the Rabbit Brain and Hypophysis

    Yves Charnay, Constantin Bouras, Philippe G. Vallet et al. · Neuroendocrinology · 2008

    Animal study20 citations

  35. Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro

    Akihiro Nakamura, Masaya Nakashima, Kenji Sakai et al. · Brain Research · 1989

    Animal study20 citations

  36. Delta-Sleep-Inducing Peptide (DSIP) Inhibited CRF-Induced ACTH Secretion from Rat Anterior Pituitary GlandIn Vitro

    Taiichiro Okajima, G. Hertting · Hormone and Metabolic Research · 1986

    Animal study20 citations

  37. Delta-sleep inducing peptide in cerebrospinal fluid from schizophrenics, depressives and healthy volunteers

    Leif Lindström, Rolf Ekman, Helena Walléus et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry · 1985

    Study in humans20 citations

  38. Immunoreactive Delta Sleep-Inducing Peptide in Pituitary Adrenocorticotropin/Alpha-Melanotropin Cells and Adrenal Medullary Cells of the Pig

    Rolf Ekman, Anders S Bjartell, Eva Ekblad et al. · Neuroendocrinology · 2008

    Animal study19 citations

  39. Delta‐Sleep‐Inducing Peptide Sequels in the Mechanisms of Resistance to Emotional Stress

    К. В. Судаков, John P. Coghlan, Kotov Av et al. · Annals of the New York Academy of Sciences · 1995

    Animal study19 citations

  40. Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP)

    Akihiro Nakamura, Masaya Nakashima, 知子 菅尾 et al. · European Journal of Pharmacology · 1988

    Animal study19 citations

LatestName in title or abstract

  1. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

    Omar F. Rahman, Steven J. Lee, William A. Seeds · JAAOS Global Research and Reviews · 2026

    ReviewOpen access · CC BY-NC-ND5 citationsRead the open copy →

  2. Changes in the concentration of melatonin and endogenous proteins regulating carbohydrate and lipid metabolism in rats under conditions of light desynchronosis with pharmacological correction by peptide extracts from the pineal gland and pituitary gland of the reindeer (Rangifer tarandus)

    A. V. Sharabanov, Батоцыренова Екатерина Геннадьевна, Tatiana Yu. Kretser et al. · Research and Practical Medicine Journal · 2025

    Open access · CC BYRead the open copy →

  3. Pharmacological Correction of Physical Performance in Male Rats with Peptide Preparations when Changing the Lighting Regime

    A. V. Sharabanov, Батоцыренова Екатерина Геннадьевна, Кашуро Вадим Анатольевич et al. · Journal Biomed · 2024

    Open access · CC BYRead the open copy →

  4. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models

    Xiaoxiao Mu, Lijun Qu, Liquan Yin et al. · Frontiers in Pharmacology · 2024

    Open access · CC BY3 citationsRead the open copy →

  5. Modified Effect of Peptide Preparations on Spontaneous Motor Activity in Male Rats under the Conditions of Light Desynchronosis

    A. V. Sharabanov, Батоцыренова Екатерина Геннадьевна, Кашуро Вадим Анатольевич et al. · Journal Biomed · 2024

    Open access · CC BYRead the open copy →

  6. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

    Elena A. Tukhovskaya, Alina M. Ismailova, Эльвира Рауильевна Шайхутдинова et al. · Molecules · 2021

    Animal studyOpen access · CC BY2 citationsRead the open copy →

  7. Effects of Delta-sleep-inducing, Kisspeptin-10 and pt-141 Neuropeptides on Sexual Behaviour in Male Rats

    Svetlana N. Subbotina, Юдин Михаил Анатольевич, А. А. Парфёнова et al. · Journal Biomed · 2021

    Open access · CC BY2 citationsRead the open copy →

  8. NEUROPEPTIDES EFFECTS ON RAT ESTROUS CYCLE DISORDERS CAUSED BY MORPHINE

    N.A. Belyakova, Evgenij Yu. Bonitenko, А. В. Носов · Toxicological Review · 2019

    Open access · CC BYRead the open copy →

  9. Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude

    Koustav Roy, Garima Chauhan, Punita Kumari et al. · Life Sciences · 2018

    Animal study13 citations

  10. Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures

    Dragan Hrnčić, Željko Grubač, Nikola Šutulović et al. · Archives of Biological Sciences · 2018

    Open access · CC BY-NC-ND1 citationsRead the open copy →

  11. Specific changes in the conformation of blood albumin molecule during stress exposures and administration of cytokines or oligopeptides

    Sergey S. Pertsov, Elena V. Koplik, Н. В. Смолина et al. · Nauchno-prakticheskii zhurnal «Patogenez» · 2017

    Open accessRead the open copy →

  12. Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris

    Xin-Guo Zhang, Wenna Wang, Chunsheng Zhang et al. · Protein and Peptide Letters · 2017

    Study in humans1 citations

  13. STUDY OF THE COMBINED INFLUENCE OF SODIUM THIOPENTAL AND DELTA SLEEP-INDUCING PEPTIDE ON ANTIOXIDANT DEFENSE SYSTEM IN RATS

    A. V. Shvetsov, Батоцыренова Екатерина Геннадьевна, Natalia A. Dyuzhikova et al. · Toxicological Review · 2016

    Open access · CC BY1 citationsRead the open copy →

  14. Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress

    Игорь Иванович Бобынцев, Alexey A. Kryukov, А. Е. Белых et al. · Bulletin of Experimental Biology and Medicine · 2016

    Animal study2 citations

  15. Role of phosphorylated delta sleep inducing peptide (p-DSIP) on sleep architecture and spatial memory impairment of rats under chronic hypobaric hypoxia

    Koustav Roy, Krishna Kishore, Koushik Ray et al. · Frontiers in Cellular Neuroscience · 2016

    Open access · CC BYRead the open copy →

  16. Морфология печени крыс в условиях острого эмоционально-болевого стресса на фоне введения дельта-сон индуцирующего пептида

    А. Е. Белых, В. Т. Дудка, И. И. Бобынцев et al. · Человек и его здоровье · 2016

    Open access · CC BY1 citationsRead the open copy →

  17. Enzymatic attributes of an l-isoaspartyl methyltransferase from Candida utilis and its role in cell survival

    Shakri Banerjee, Trina Dutta, Sagar Lahiri et al. · Biochemistry and Biophysics Reports · 2015

    Open access · CC BY-NC-ND1 citationsRead the open copy →

  18. Influence of delta-sleep peptide on the enzymatic activity of the mitochondrial electron transport chain in various rat tissues with aging of the organism

    Т. И. Бондаренко, Denis S. Kutilin, I. I. Mihaleva · Advances in Gerontology · 2015

    Animal study

  19. Influence of delta-sleep inducing peptide on the state of lysosomal membranes and the intensity of lysosomal proteolysis in different rat tissues with physiological aging of the organism

    Denis S. Kutilin, Т. И. Бондаренко, I. I. Mihaleva · Advances in Gerontology · 2015

    Animal study5 citations

  20. The infl uence of the treatment with deltalycyn on clinical, functional and morphological manifestations of diabetic retinopathy

    N. V. Kresyun · Zaporozhye Medical Journal · 2014

    Open access · CC BYRead the open copy →

  21. Neurodegenrative changes in retina of rats with streptozotocin diabetes under different conditions of experimental treatment

    N. V. Kresyun · Zaporozhye Medical Journal · 2014

    Open access · CC BYRead the open copy →

  22. Effect of Delta Sleep-Inducing Peptide on the Expression of Antioxidant Enzyme Genes in the Brain and Blood of Rats during Physiological Aging

    Denis S. Kutilin, Т. И. Бондаренко, И. В. Корниенко et al. · Bulletin of Experimental Biology and Medicine · 2014

    Animal study6 citations

  23. Delta-sleep inducing peptide entrapment in the charged macroporous matrices

    T. V. Sukhanova, Alexander A. Artyukhov, Yakov M. Gurevich et al. · Materials Science and Engineering C · 2014

  24. Streptozotocin-Induced Diabetes-Related Changes in the Functional State of the Rat Retina: Possibilities for Correction Using Delta Sleep-Inducing Peptide

    N. V. Kresyun, Годлевский Леонид Семенович, V. A. Polyasny · Neurophysiology · 2014

  25. Antioxidant and detoxifying activities of analogues of the delta sleep inducing peptide

    Inessa I. Mikhaleva, В. Т. Иванов, Lyudmila V. Onoprienko et al. · Russian Journal of Bioorganic Chemistry · 2014

    Animal study1 citations

  26. The KND olygopeptide as a putative endogenous prototype of Delta Sleep Inducing Peptide (DSIP). comparative study of biological properties

    Inessa I. Mikhaleva, В. Т. Иванов, В. Б. Войтенков et al. · Russian Journal of Bioorganic Chemistry · 2013

    Study in humans2 citations

  27. Effect of delta-sleep-inducing peptide on the functional activity of certain organs and tissues of rats in the physiological aging of an organism

    Т. И. Бондаренко, E. A. Mayboroda, Inessa I. Mikhaleva et al. · Advances in Gerontology · 2013

  28. Delta-sleep inducing peptide entrapment and release from polymer hydrogels based on modified polyvinyl alcohol

    T. V. Sukhanova, Alexander A. Artyukhov, И. А. Прудченко et al. · Biomeditsinskaya Khimiya · 2013

    Study in humansOpen access1 citationsRead the open copy →

  29. Влияния пептида дельта-сна на активность нейронов дорзального гиппокампа крыс с различной поведенческой активностью в условиях стимуляции положительной и отрицательной эмоциогенных структур мозга

    О. С. Григорчук · Журнал высшей нервной деятельности им И П Павлова · 2013

    Animal study

  30. Delta-sleep inducing peptide and neuronal activity in dorsal hyppocampus after ventro-medial hypothalamus stimulation

    О. С. Григорчук, Pavel E. Umriukhin · I P Pavlov Russian Medical Biological Herald · 2012

    Open access · CC BYRead the open copy →

  31. Inability to Replicate Cerebrospinal Fluid Histamine Deficits in the Primary Hypersomnias: A Back to the Drawing Board Moment

    David B. Rye · SLEEP · 2012

    Study in humansOpen access3 citationsRead the open copy →

  32. Neuronal Activity in the Dorsal Hippocampus after Lateral Hypothalamus Stimulation: Effects of Delta-Sleep-Inducing Peptide

    О. С. Григорчук, Pavel E. Umriukhin · Bulletin of Experimental Biology and Medicine · 2012

    Animal study1 citations

  33. Effect of Delta Sleep-Inducing Peptide on Oxidative Modification of Proteins in Rat Tissues and Blood during Physiological Aging

    Т. И. Бондаренко, И. А. Сорокина, E. A. Mayboroda et al. · Bulletin of Experimental Biology and Medicine · 2012

    Animal study5 citations

  34. Entrapment and in vitro release of delta-sleep inducing peptide from polymer hydrogels based on modified polyvinyl alcohol

    T. V. Sukhanova, Alexander A. Artyukhov, И. А. Прудченко et al. · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · 2012

  35. Dizocilpine and cycloheximide prevent inhibition of c-Fos gene expression by delta sleep-inducing peptide in the paraventricular nucleus of the hypothalamus in rats with different resistance to emotional stress

    Pavel E. Umriukhin, Elena V. Koplik, К. В. Судаков · Neuroscience Letters · 2011

    Animal study4 citations

  36. Mechanism of geroprotective action of delta-sleep inducing peptide

    Т. И. Бондаренко, E A Maĭboroda, Inessa I. Mikhaleva et al. · Advances in Gerontology · 2011

    5 citations

  37. Changes in Duodenal Lymphoid Structures in Rats with Different Levels of Behavioral Activity Treated with Delta Sleep-Inducing Peptide and during Acute Emotional Stress

    Е. А. Иванова, Elena V. Koplik · Neuroscience and Behavioral Physiology · 2011

    1 citations

  38. JmjC-domain-containing histone demethylases of the JMJD1B type as putative precursors of endogenous DSIP

    Inessa I. Mikhaleva, И. А. Прудченко, Vadim T. Ivanov et al. · Peptides · 2011

    Study in humans11 citations

  39. Delta sleep‐inducing peptide and glucocorticoid‐induced leucine zipper: potential links between circadian mechanisms and obesity?

    Jeffrey M. Gimble, Andrey A. Ptitsyn, Brian Chun Kim Goh et al. · Obesity Reviews · 2009

    Review17 citations

  40. P.7.a.006 Delta sleep-inducing peptide analogue corrects the CNS functional state of children treated with antiblastomic therapy

    A. B. Sinyukhin, G.P. Timoshinov, Владимир Александрович Корнилов et al. · European Neuropsychopharmacology · 2009

Each list shows up to 40 papers.See all 347 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.