ARA-290 studies
50 journal papers mention ARA-290 in the title or abstract. Here are the most cited, the latest, and a few facts about the literature.
Studies range from laboratory work to clinical trials. A paper listed here is not an endorsement and says nothing about whether ARA-290 is safe, effective or approved for any use.
- Papers
- 50
- 42 articles, 8 reviews
- Earliest paper
- 2010
- Most papers in 2026 (9)
- Open access
- 74%
- free to read somewhere
- Reviews
- 16%
- of all papers listed
What kind of studies
Of 37 papers in PubMed that mention ARA-290 in the title or abstract, by the study type PubMed records. Categories overlap, so they do not add up to the total.
- Randomized controlled trials3
- Other clinical trials1
- Meta-analyses and systematic reviews2
- Other reviews6
- Case reports1
- Animal studies only9
- Studies in humans21
Study types are tags assigned by publishers and PubMed indexers; very new papers are often not tagged yet, and a tag is not a quality rating. Retracted papers are excluded. Source: PubMed (NCBI).
Registered clinical studies
Studies on ClinicalTrials.gov that mention ARA-290 in their intervention details. A registration says a study is planned or running, not what it found.
- Registered
- 4
- Completed
- 2
- Ongoing or planned
- 0
- Phase 1
- 1
- Phase 2
- 4
- Phase 3
- 0
- The Use of ARA290 for the Treatment of Diabetic Macular Oedema
NCT06626971TerminatedPhase 2started 2016-04
- Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis
NCT02039687CompletedPhase 2started 2014-01
- ARA290 in T2D (Effects of ARA 290, an Erythropoietin Analogue) in Prediabetes and Type 2 Diabetes)
NCT01933529Status unknownPhase 2started 2013-10
- Cognitive and Neural Effects of ARA290
NCT02070783CompletedPhase 1 / Phase 2started 2012-02
The five most recently updated studies. See all 4 on ClinicalTrials.gov. Source: ClinicalTrials.gov (U.S. National Library of Medicine). Studies are found by the compound's name, so a few may be about something else.
Papers per year
2010 to 2026, peak 9 papers in a year. The latest year may still be incomplete.
Where it is published
- Molecular Medicine4 papers
- Transplantation3 papers
- Bone Reports3 papers
- Research Results in Pharmacology3 papers
- Journal of Vascular Surgery2 papers
The papers
Most citedName in the title
- ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes
Michael L. Brines, Ann N. Dunne, Monique van Velzen et al. · Molecular Medicine · 2014
Clinical trial · Phase 2Open access · CC BY-NC-ND146 citationsRead the open copy →
- Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Study
Lara Rosaline Heij, Marieke Niesters, Maarten Swartjes et al. · Molecular Medicine · 2012
Randomized trialOpen access · CC BY-NC-ND114 citationsRead the open copy →
- Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain
Daniel A. Culver, Albert Dahan, Daiva R. Bajorunas et al. · Investigative Ophthalmology & Visual Science · 2017
Randomized trialOpen access · CC BY104 citationsRead the open copy →
- ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Increases Corneal Nerve Fiber Density
Albert Dahan, Ann N. Dunne, Maarten Swartjes et al. · Molecular Medicine · 2013
Randomized trialOpen access · CC BY-NC-ND96 citationsRead the open copy →
- ARA 290 for treatment of small fiber neuropathy in sarcoidosis
Monique van Velzen, Lara Rosaline Heij, Marieke Niesters et al. · Expert Opinion on Investigational Drugs · 2014
Review43 citations
- ARA 290, a Peptide Derived from the Tertiary Structure of Erythropoietin, Produces Long-Term Relief of Neuropathic Pain Coupled with Suppression of the Spinal Microglia Response
Maarten Swartjes, Monique van Velzen, Marieke Niesters et al. · Molecular Pain · 2014
Animal studyOpen access · CC BY37 citationsRead the open copy →
- A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets
Masaaki Watanabe, Torbjörn Lundgren, Yu Saito et al. · Transplantation · 2015
Animal study31 citations
- The erythropoietin analog ARA 290 for treatment of sarcoidosis-induced chronic neuropathic pain
Marieke Niesters, Maarten Swartjes, Lara Rosaline Heij et al. · Expert Opinion on Orphan Drugs · 2012
22 citations
- Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression
Mohammed Al‐Onaizi, Peter Thériault, Sarah Lecordier et al. · Brain Behavior and Immunity · 2021
Animal study20 citations
- The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic
Olivia E. O'Leary, Paul Canning, Emma Reid et al. · Experimental Eye Research · 2019
Study in humansOpen access · CC BY-SA20 citationsRead the open copy →
- Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
Manfred Nairz, David Haschka, Stefanie Dichtl et al. · Scientific Reports · 2017
Study in humansOpen access · CC BY20 citationsRead the open copy →
- ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception
Wenjia Zhang, Guanling Yu, Mengyuan Zhang · Peptides · 2016
Study in humans19 citations
- Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes
Alessandra Bitto, Natasha Irrera, Gabriele Pizzino et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2017
Animal studyOpen access17 citationsRead the open copy →
- A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema
Noemi Lois, Evie Gardner, Margaret McFarland et al. · Journal of Clinical Medicine · 2020
Open access · CC BY11 citationsRead the open copy →
- Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation
Ming Han Yao, Anna Domogatskaya, Nils Ågren et al. · Cell Transplantation · 2021
Study in humansOpen access · CC BY9 citationsRead the open copy →
- The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice
Zamzam Awida, Almog Bachar, Hussam Saed et al. · International Journal of Molecular Sciences · 2021
Animal studyOpen access · CC BY7 citationsRead the open copy →
- Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
Ming Han Yao, Masaaki Watanabe, Sune Sun et al. · Transplantation · 2020
Animal studyOpen access · CC BY-NC-ND6 citationsRead the open copy →
- An Engineered Innate Repair Receptor Agonist, ARA 290, Protects Rat Islets from Cytokine-induced Apoptosis
Masaaki Watanabe, Yu Saito, Jesper Wallmo et al. · Journal of Diabetes & Metabolism · 2016
Open access2 citationsRead the open copy →
- ARA-290 (CIBINETIDE) IN THE TREATMENT OF CHRONIC AND NEUROPATHIC PAIN: MECHANISMS OF ACTION, CLINICAL EFFICACY, DOSE–EXPOSURE–RESPONSE RELATIONSHIP, NEUROREGENERATION, AND SAFETY
Luiz Felippe Mendes Caquetti · INTERNATIONAL BLEST SCIENTIFIC · 2026
Open accessRead the open copy →
- Exploring the Efficacy of the Non-Erythropoietic Peptide ARA 290 on Visuospatial Learning and Cognitive Flexibility in a Mouse Model of Diabetic Vasculopathy
Dalal Alasousi, Kawthar Braysh, Leora D'Souza et al. · Cerebral Circulation - Cognition and Behavior · 2025
Open access · CC BY-NC-NDRead the open copy →
- The non-erythropoietic analogue cibinetide inhibits osteoclastogenesis in vitro and increases bone density in mice
Zamzam Awida, Albert Kolomansky, Sahar Hiram‐Bab et al. · Bone Reports · 2020
Open access · CC BY-NC-NDRead the open copy →
- Improvement of Metabolic Function after Intra-Portal Allogeneic Islet Transplantation Using Induction Treatment of the Non-Hematopoetic Erythropoietin Analogue Cibinetide in a Mouse Model
Ming Han Yao, Masaaki Watanabe, Sune Sun et al. · Transplantation · 2018
LatestName in title or abstract
- Regenerative peptides for inferior alveolar nerve injury: a narrative review
Scott H. Froum, Nathan E. Estrin, Gianna Pico et al. · Frontiers in Dental Medicine · 2026
ReviewOpen access · CC BYRead the open copy →
- Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases
Scott H. Froum, Nathan E. Estrin, Gianna Pico et al. · Frontiers in Oral Health · 2026
Case reportOpen access · CC BYRead the open copy →
- Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management
Choopong Luansritisakul, Monping Chiang, Stacey L. Burns et al. · Current Pain and Headache Reports · 2026
Review
- Pharmacological Management of Diabetic Neuropathy: Current Evidence, Clinical Positioning, and Emerging Therapeutic Targets
Ali Hikmat Alburghaif, Hany Akeel Al-Hussaniy, Jihad Maan et al. · Current Neuropharmacology · 2026
- ARA-290 (CIBINETIDE) IN THE TREATMENT OF CHRONIC AND NEUROPATHIC PAIN: MECHANISMS OF ACTION, CLINICAL EFFICACY, DOSE–EXPOSURE–RESPONSE RELATIONSHIP, NEUROREGENERATION, AND SAFETY
Luiz Felippe Mendes Caquetti · INTERNATIONAL BLEST SCIENTIFIC · 2026
Open accessRead the open copy →
- Immunometabolic dysregulation drives selective executive cognitive dysfunction in male db/db mice
Dalal Alasousi, Kawthar Braysh, Leora D’Souza et al. · Neurobiology of Disease · 2026
Animal studyOpen access · CC BYRead the open copy →
- Evaluation of pharmacological correction of hypoxic-ischemic encephalopathy sequelae using peptide erythropoietin analogs in a mouse model of mild and moderate hypoxic-ischemic encephalopathy during the late remodeling phase
Vladimir M. Pokrovsky · Research Results in Pharmacology · 2026
Open access · CC BYRead the open copy →
- Evaluation of the neuroprotective effects of synthetic erythropoietin derivatives in a mouse model of mild and moderate hypoxic-ischemic encephalopathy
Михаил Викторович Корокин, Ivan V. Chatsky, Sofia A. Kushnir et al. · Research Results in Pharmacology · 2026
Open access · CC BYRead the open copy →
- Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy
Yujin Sun, Bo Song, Yonglei Zhang et al. · Frontiers in Neurology · 2026
ReviewOpen access · CC BYRead the open copy →
- Exploring the Efficacy of the Non-Erythropoietic Peptide ARA 290 on Visuospatial Learning and Cognitive Flexibility in a Mouse Model of Diabetic Vasculopathy
Dalal Alasousi, Kawthar Braysh, Leora D'Souza et al. · Cerebral Circulation - Cognition and Behavior · 2025
Open access · CC BY-NC-NDRead the open copy →
- Study of the neuroprotective properties of the heteroreceptor EPOR/CD131 agonist of peptide structure in tau-proteinopathy modeling
Yulia V. Stepenko, Veronika S. Shmigerova, Darya A. Kostina et al. · Research Results in Pharmacology · 2024
Open access · CC BY4 citationsRead the open copy →
- Оценка нейропротекторной активности пептидного миметика гетерорецептора EPOR/CD131 при моделировании нейродегенеративных процессов
Yulia V. Stepenko, Т. Г. Покровская, Михаил Викторович Корокин et al. · Экспериментальная и клиническая фармакология · 2024
Open accessRead the open copy →
- A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan
Nolan M. Winicki, Alay P. Nanavati, Christopher H. Morrell et al. · Frontiers in Cardiovascular Medicine · 2023
Open access · CC BY3 citationsRead the open copy →
- Mechanistic Approach for Protective Effect of ARA290, a Specific Ligand for the Erythropoietin/CD131 Heteroreceptor, against Cisplatin-Induced Nephrotoxicity, the Involvement of Apoptosis and Inflammation Pathways
Nasrin Ghassemi-Barghi, Zeynab Ehsanfar, Omid Mohammadrezakhani et al. · Inflammation · 2022
Study in humans21 citations
- The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice
Zamzam Awida, Almog Bachar, Hussam Saed et al. · International Journal of Molecular Sciences · 2021
Animal studyOpen access · CC BY7 citationsRead the open copy →
- Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression
Mohammed Al‐Onaizi, Peter Thériault, Sarah Lecordier et al. · Brain Behavior and Immunity · 2021
Animal study20 citations
- The time to develop treatments for diabetic neuropathy
Marc Rendell · Expert Opinion on Investigational Drugs · 2021
Systematic review10 citations
- Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation
Ming Han Yao, Anna Domogatskaya, Nils Ågren et al. · Cell Transplantation · 2021
Study in humansOpen access · CC BY9 citationsRead the open copy →
- Nonhematopoietic erythropoietin-derived peptide: Study of the atheroprotective activity using a novel murine model of mitochondrial dysfunction
Михаил Викторович Корокин, M. V. Pokrovsky, Marina V. Kubekina et al. · Atherosclerosis · 2020
- Bone remodeling mechanisms in osteoporotic TgRANKL transgenic mouse models
Vagelis E. Rinotas, Panagiotis N. Nikolaou, Konstantinos Kritikos et al. · Bone Reports · 2020
Open access · CC BY-NC-NDRead the open copy →
- The non-erythropoietic analogue cibinetide inhibits osteoclastogenesis in vitro and increases bone density in mice
Zamzam Awida, Albert Kolomansky, Sahar Hiram‐Bab et al. · Bone Reports · 2020
Open access · CC BY-NC-NDRead the open copy →
- Noggin as a regulator of bone remodelling
Fatemeh Safari, Mark Siegrist, Silvia Dolder et al. · Bone Reports · 2020
Open access · CC BY-NC-NDRead the open copy →
- A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema
Noemi Lois, Evie Gardner, Margaret McFarland et al. · Journal of Clinical Medicine · 2020
Open access · CC BY11 citationsRead the open copy →
- Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
Ming Han Yao, Masaaki Watanabe, Sune Sun et al. · Transplantation · 2020
Animal studyOpen access · CC BY-NC-ND6 citationsRead the open copy →
- An engineered non-erythropoietic erythropoietin-derived peptide, ARA290, attenuates doxorubicin induced genotoxicity and oxidative stress
Mohammad Shokrzadeh, Mahmoud Etebari, Nasrin Ghassemi-Barghi · Toxicology in Vitro · 2020
Study in humans30 citations
- The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic
Olivia E. O'Leary, Paul Canning, Emma Reid et al. · Experimental Eye Research · 2019
Study in humansOpen access · CC BY-SA20 citationsRead the open copy →
- Improvement of Metabolic Function after Intra-Portal Allogeneic Islet Transplantation Using Induction Treatment of the Non-Hematopoetic Erythropoietin Analogue Cibinetide in a Mouse Model
Ming Han Yao, Masaaki Watanabe, Sune Sun et al. · Transplantation · 2018
- Corneal nerve fiber size adds utility to the diagnosis and assessment of therapeutic response in patients with small fiber neuropathy
Michael L. Brines, Daniel A. Culver, Maryam Ferdousi et al. · Scientific Reports · 2018
Study in humansOpen access · CC BY89 citationsRead the open copy →
- Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes
Alessandra Bitto, Natasha Irrera, Gabriele Pizzino et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2017
Animal studyOpen access17 citationsRead the open copy →
- Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
Manfred Nairz, David Haschka, Stefanie Dichtl et al. · Scientific Reports · 2017
Study in humansOpen access · CC BY20 citationsRead the open copy →
- Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain
Daniel A. Culver, Albert Dahan, Daiva R. Bajorunas et al. · Investigative Ophthalmology & Visual Science · 2017
Randomized trialOpen access · CC BY104 citationsRead the open copy →
- Managing fatigue in sarcoidosis – A systematic review of the evidence
Christopher Atkins, Andrew M. Wilson · Chronic Respiratory Disease · 2016
Systematic reviewOpen access40 citationsRead the open copy →
- ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception
Wenjia Zhang, Guanling Yu, Mengyuan Zhang · Peptides · 2016
Study in humans19 citations
- An Engineered Innate Repair Receptor Agonist, ARA 290, Protects Rat Islets from Cytokine-induced Apoptosis
Masaaki Watanabe, Yu Saito, Jesper Wallmo et al. · Journal of Diabetes & Metabolism · 2016
Open access2 citationsRead the open copy →
- A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets
Masaaki Watanabe, Torbjörn Lundgren, Yu Saito et al. · Transplantation · 2015
Animal study31 citations
- Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin
Massimo Collino, Christoph Thiemermann, Anthony Cerami et al. · Pharmacology & Therapeutics · 2015
ReviewOpen access · CC BY-NC-ND92 citationsRead the open copy →
- The Role of Erythropoietin in Skeletal Muscle Ischaemia In Vitro and In Vivo
Rebekah Sian Hwee Yu, Daryll Baker, Shyam K. Kolvekar et al. · European Journal of Vascular and Endovascular Surgery · 2014
Open access1 citationsRead the open copy →
- Erythropoietin-Derived Nonerythropoietic Peptide Ameliorates Experimental Autoimmune Neuritis by Inflammation Suppression and Tissue Protection
Yuqi Liu, Bangwei Luo, Fuyu Han et al. · PLoS ONE · 2014
Animal studyOpen access · CC BY35 citationsRead the open copy →
- ARA 290 for treatment of small fiber neuropathy in sarcoidosis
Monique van Velzen, Lara Rosaline Heij, Marieke Niesters et al. · Expert Opinion on Investigational Drugs · 2014
Review43 citations
- ARA 290, a Peptide Derived from the Tertiary Structure of Erythropoietin, Produces Long-Term Relief of Neuropathic Pain Coupled with Suppression of the Spinal Microglia Response
Maarten Swartjes, Monique van Velzen, Marieke Niesters et al. · Molecular Pain · 2014
Animal studyOpen access · CC BY37 citationsRead the open copy →
Each list shows up to 40 papers.See all 50 on OpenAlex. Source: OpenAlex (CC0), journal articles and reviews with a DOI, retractions excluded, refreshed weekly, last 4 Nov 2026, 08:26 UTC. Papers are listed by their metadata only; follow the links to read them. A license shown on an open copy is the license the publisher or repository states for that copy.